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Article: CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features

TitleCD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features
Authors
Issue Date2020
PublisherCell Press. The Journal's web site is located at http://cell.com/cell-reports
Citation
Cell reports, 2020, v. 32, p. 107885 How to Cite?
AbstractT cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4+ T cells. Here, we investigate CD4+ T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4+ T cells in five HLA-DR1+ subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies.
Persistent Identifierhttp://hdl.handle.net/10722/290809

 

DC FieldValueLanguage
dc.contributor.authorGreenshields-Watson, A-
dc.contributor.authorAttaf, M-
dc.contributor.authorMacLachlan, B J-
dc.contributor.authorWhaley, T-
dc.contributor.authorRius, C-
dc.contributor.authorWall, A-
dc.contributor.authorLloyd, A-
dc.contributor.authorHughes, H-
dc.contributor.authorStrange, K E-
dc.contributor.authorMason, G H-
dc.contributor.authorSchauenburg, A J-
dc.contributor.authorHulin-Curtis, S L-
dc.contributor.authorGeary, J-
dc.contributor.authorChen, Y-
dc.contributor.authorLauder, S N-
dc.contributor.authorSmart, K-
dc.contributor.authorDhanasekaran, V-
dc.contributor.authorGrau, M L-
dc.contributor.authorShugay, M-
dc.contributor.authorAndrews, R-
dc.contributor.authorDolton, G-
dc.contributor.authorRizkallah, P J-
dc.contributor.authorGallimore, A M-
dc.contributor.authorSewell, A K-
dc.contributor.authorGodkin, A J-
dc.contributor.authorCole, D K-
dc.date.accessioned2020-11-02T05:47:26Z-
dc.date.available2020-11-02T05:47:26Z-
dc.date.issued2020-
dc.identifier.citationCell reports, 2020, v. 32, p. 107885-
dc.identifier.urihttp://hdl.handle.net/10722/290809-
dc.description.abstractT cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4+ T cells. Here, we investigate CD4+ T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4+ T cells in five HLA-DR1+ subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies.-
dc.languageeng-
dc.publisherCell Press. The Journal's web site is located at http://cell.com/cell-reports-
dc.relation.ispartofCell reports-
dc.titleCD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features-
dc.typeArticle-
dc.identifier.emailDhanasekaran, V: veej@hku.hk-
dc.identifier.authorityDhanasekaran, V=rp02721-
dc.identifier.hkuros317642-
dc.identifier.volume32-
dc.identifier.spage107885-
dc.identifier.epage107885-

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