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Article: Human post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2

TitleHuman post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2
Authors
Xiao, CLing, SQiu, MDeng, ZChen, LZhu, AChen, YLiu, YLin, XLin, FWu, QShen, LYe, FLiu, XLi, YZhao, JYang, ZCowling, BJWebby, RZanin, MWong, SS
Keywordsantibodies
epidemiology
nucleocapsid
SARS‐CoV‐2
serology
Issue Date2021
PublisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1750-2659
Citation
Influenza and Other Respiratory Viruses, 2021, v. 15 n. 1, p. 7-12 How to Cite?
DOI: http://dx.doi.org/10.1111/irv.12798
AbstractTo inform seroepidemiological studies, we characterized the IgG‐ responses in COVID‐19 patients against the two major SARS‐CoV‐2 viral proteins, spike (S) and nucleocapsid (N). We tested 70 COVID‐19 sera collected up to 85 days post‐symptom onset and 230 non‐COVID‐19 sera, including 27 SARS sera from 2003. Although the average SARS‐CoV‐2 S and N‐IgG titers were comparable, N‐responses were more variable among individuals. S‐ and N‐assay specificity tested with non‐COVID‐19 sera were comparable at 97.5% and 97.0%, respectively. Therefore, S will make a better target due to its lower cross‐reactive potential and its' more consistent frequency of detection compared to N.
Persistent Identifierhttp://hdl.handle.net/10722/290824
ISSN
1750-2640
2020 Impact Factor: 4.38
2020 SCImago Journal Rankings: 1.743
PubMed Central ID
PMC7461388
ISI Accession Number ID
WOS:000562357700001

 

DC FieldValueLanguage
dc.contributor.authorXiao, C-
dc.contributor.authorLing, S-
dc.contributor.authorQiu, M-
dc.contributor.authorDeng, Z-
dc.contributor.authorChen, L-
dc.contributor.authorZhu, A-
dc.contributor.authorChen, Y-
dc.contributor.authorLiu, Y-
dc.contributor.authorLin, X-
dc.contributor.authorLin, F-
dc.contributor.authorWu, Q-
dc.contributor.authorShen, L-
dc.contributor.authorYe, F-
dc.contributor.authorLiu, X-
dc.contributor.authorLi, Y-
dc.contributor.authorZhao, J-
dc.contributor.authorYang, Z-
dc.contributor.authorCowling, BJ-
dc.contributor.authorWebby, R-
dc.contributor.authorZanin, M-
dc.contributor.authorWong, SS-
dc.date.accessioned2020-11-02T05:47:39Z-
dc.date.available2020-11-02T05:47:39Z-
dc.date.issued2021-
dc.identifier.citationInfluenza and Other Respiratory Viruses, 2021, v. 15 n. 1, p. 7-12-
dc.identifier.issn1750-2640-
dc.identifier.urihttp://hdl.handle.net/10722/290824-
dc.description.abstractTo inform seroepidemiological studies, we characterized the IgG‐ responses in COVID‐19 patients against the two major SARS‐CoV‐2 viral proteins, spike (S) and nucleocapsid (N). We tested 70 COVID‐19 sera collected up to 85 days post‐symptom onset and 230 non‐COVID‐19 sera, including 27 SARS sera from 2003. Although the average SARS‐CoV‐2 S and N‐IgG titers were comparable, N‐responses were more variable among individuals. S‐ and N‐assay specificity tested with non‐COVID‐19 sera were comparable at 97.5% and 97.0%, respectively. Therefore, S will make a better target due to its lower cross‐reactive potential and its' more consistent frequency of detection compared to N.-
dc.languageeng-
dc.publisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1750-2659-
dc.relation.ispartofInfluenza and Other Respiratory Viruses-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectantibodies-
dc.subjectepidemiology-
dc.subjectnucleocapsid-
dc.subjectSARS‐CoV‐2-
dc.subjectserology-
dc.titleHuman post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2-
dc.typeArticle-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.authorityCowling, BJ=rp01326-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/irv.12798-
dc.identifier.pmid32844604-
dc.identifier.pmcidPMC7461388-
dc.identifier.scopuseid_2-s2.0-85089785716-
dc.identifier.hkuros318566-
dc.identifier.volume15-
dc.identifier.issue1-
dc.identifier.spage7-
dc.identifier.epage12-
dc.identifier.isiWOS:000562357700001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1750-2640-

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