File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Th2 cell regulatory and effector molecules single nucleotide polymorphisms and periodontitis

TitleTh2 cell regulatory and effector molecules single nucleotide polymorphisms and periodontitis
Authors
KeywordsCTLA-4 antigen
IL-6
periodontitis
polymorphisms
single nucleotide
Issue Date2020
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at https://jlb.onlinelibrary.wiley.com/journal/19383673
Citation
Journal of Leukocyte Biology, 2020, v. 108 n. 5, p. 1641-1654 How to Cite?
AbstractTo investigate the association between T helper 2 (Th2) cell regulatory and effector molecules’ genetic polymorphisms and periodontitis. Single nucleotide polymorphisms (SNPs) of 11 Th2 cell regulatory or effector molecules genes (CD28, CTLA4, IL4, IL5, IL6, IL9, IL10, IL13, IL4R, GATA3, STAT6, and rs1537415; total 130 SNPs) were studied in Chinese nonsmokers (163 periodontitis-free controls, 141 periodontitis patients) using Sequenom iPlex assays. SNPs potentially associated with periodontitis (adjusted allelic P < 0.1) in this cross-sectional study were further investigated via meta-analysis. Allele G of rs4553808 in promoter of CTLA4 was more frequently detected in periodontitis than controls (P < 0.005), but did not remain significant after age and gender adjustment. Haplotype (GTT) in a block of three CTLA4 SNPs (rs4553808, rs16840252, rs5742909) was significantly associated with periodontitis. Meta-analysis of SNPs identified indicated allele T of CTLA4 rs5742909 (3 studies; 461 control, 369 periodontitis) and allele G of IL6 rs1800796 (18 studies; 2760 control, 2442 periodontitis) were significantly associated with periodontitis (OR = 1.44 and OR = 1.30, respectively). Within limitations of this study, a haplotype of CTLA4 concerning Th2 cell regulation, may be associated with periodontitis in Chinese nonsmokers followed. Meta-analysis indicated rs5742909 of CTLA4 and rs1800796 of IL6 appeared significantly associated with periodontitis. ©2020 Society for Leukocyte Biology
Persistent Identifierhttp://hdl.handle.net/10722/290868
ISSN
2019 Impact Factor: 3.757
2015 SCImago Journal Rankings: 2.463

 

DC FieldValueLanguage
dc.contributor.authorZheng, Y-
dc.contributor.authorChai, L-
dc.contributor.authorFan, Y-
dc.contributor.authorSong, YQ-
dc.contributor.authorZee, KY-
dc.contributor.authorTu, WW-
dc.contributor.authorJin, L-
dc.contributor.authorLeung, WK-
dc.date.accessioned2020-11-02T05:48:15Z-
dc.date.available2020-11-02T05:48:15Z-
dc.date.issued2020-
dc.identifier.citationJournal of Leukocyte Biology, 2020, v. 108 n. 5, p. 1641-1654-
dc.identifier.issn0741-5400-
dc.identifier.urihttp://hdl.handle.net/10722/290868-
dc.description.abstractTo investigate the association between T helper 2 (Th2) cell regulatory and effector molecules’ genetic polymorphisms and periodontitis. Single nucleotide polymorphisms (SNPs) of 11 Th2 cell regulatory or effector molecules genes (CD28, CTLA4, IL4, IL5, IL6, IL9, IL10, IL13, IL4R, GATA3, STAT6, and rs1537415; total 130 SNPs) were studied in Chinese nonsmokers (163 periodontitis-free controls, 141 periodontitis patients) using Sequenom iPlex assays. SNPs potentially associated with periodontitis (adjusted allelic P < 0.1) in this cross-sectional study were further investigated via meta-analysis. Allele G of rs4553808 in promoter of CTLA4 was more frequently detected in periodontitis than controls (P < 0.005), but did not remain significant after age and gender adjustment. Haplotype (GTT) in a block of three CTLA4 SNPs (rs4553808, rs16840252, rs5742909) was significantly associated with periodontitis. Meta-analysis of SNPs identified indicated allele T of CTLA4 rs5742909 (3 studies; 461 control, 369 periodontitis) and allele G of IL6 rs1800796 (18 studies; 2760 control, 2442 periodontitis) were significantly associated with periodontitis (OR = 1.44 and OR = 1.30, respectively). Within limitations of this study, a haplotype of CTLA4 concerning Th2 cell regulation, may be associated with periodontitis in Chinese nonsmokers followed. Meta-analysis indicated rs5742909 of CTLA4 and rs1800796 of IL6 appeared significantly associated with periodontitis. ©2020 Society for Leukocyte Biology-
dc.languageeng-
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at https://jlb.onlinelibrary.wiley.com/journal/19383673-
dc.relation.ispartofJournal of Leukocyte Biology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectCTLA-4 antigen-
dc.subjectIL-6-
dc.subjectperiodontitis-
dc.subjectpolymorphisms-
dc.subjectsingle nucleotide-
dc.titleTh2 cell regulatory and effector molecules single nucleotide polymorphisms and periodontitis-
dc.typeArticle-
dc.identifier.emailZheng, Y: jyzheng@hku.hk-
dc.identifier.emailJin, L: ljjin@hkucc.hku.hk-
dc.identifier.emailLeung, WK: ewkleung@hkucc.hku.hk-
dc.identifier.authorityJin, L=rp00028-
dc.identifier.authorityLeung, WK=rp00019-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/JLB.4MA0720-698RR-
dc.identifier.pmid32745291-
dc.identifier.scopuseid_2-s2.0-85088870111-
dc.identifier.hkuros318429-
dc.identifier.volume108-
dc.identifier.issue5-
dc.identifier.spage1641-
dc.identifier.epage1654-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats