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- Publisher Website: 10.1016/j.molcel.2007.10.035
- Scopus: eid_2-s2.0-37349025432
- PMID: 18158893
- WOS: WOS:000252170000003
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Article: FOXO3a Is Activated in Response to Hypoxic Stress and Inhibits HIF1-Induced Apoptosis via Regulation of CITED2
Title | FOXO3a Is Activated in Response to Hypoxic Stress and Inhibits HIF1-Induced Apoptosis via Regulation of CITED2 |
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Authors | |
Keywords | CELLCYCLE SIGNALING |
Issue Date | 2007 |
Citation | Molecular Cell, 2007, v. 28, n. 6, p. 941-953 How to Cite? |
Abstract | FOXO transcription factors are important regulators of cell survival in response to a variety of stress stimuli, among which are oxidative stress, DNA damage, and nutrient deprivation. Here we report a role for FOXO3a under conditions of hypoxic stress. In response to hypoxia, FOXO3a transcript levels accumulate in an HIF1-dependent way, resulting in enhanced FOXO3a activity. We show that transcription of CITED2, a transcriptional cofactor that functions in a negative feedback loop to control HIF1 activity, is induced by FOXO3a during hypoxia. In fibroblasts as well as in breast cancer cells, FOXO3a inhibits HIF1-induced apoptosis by stimulating the transcription of CITED2, which results in reduced expression of the proapoptotic HIF1 target genes NIX and RTP801. Thus, by fine-tuning HIF1 activity, FOXO3a plays an important role in the survival response of normal and cancer cells in response to hypoxic stress. © 2007 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/291804 |
ISSN | 2021 Impact Factor: 19.328 2020 SCImago Journal Rankings: 12.615 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Bakker, Walbert J. | - |
dc.contributor.author | Harris, Isaac S. | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:55:09Z | - |
dc.date.available | 2020-11-17T14:55:09Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Molecular Cell, 2007, v. 28, n. 6, p. 941-953 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291804 | - |
dc.description.abstract | FOXO transcription factors are important regulators of cell survival in response to a variety of stress stimuli, among which are oxidative stress, DNA damage, and nutrient deprivation. Here we report a role for FOXO3a under conditions of hypoxic stress. In response to hypoxia, FOXO3a transcript levels accumulate in an HIF1-dependent way, resulting in enhanced FOXO3a activity. We show that transcription of CITED2, a transcriptional cofactor that functions in a negative feedback loop to control HIF1 activity, is induced by FOXO3a during hypoxia. In fibroblasts as well as in breast cancer cells, FOXO3a inhibits HIF1-induced apoptosis by stimulating the transcription of CITED2, which results in reduced expression of the proapoptotic HIF1 target genes NIX and RTP801. Thus, by fine-tuning HIF1 activity, FOXO3a plays an important role in the survival response of normal and cancer cells in response to hypoxic stress. © 2007 Elsevier Inc. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Molecular Cell | - |
dc.subject | CELLCYCLE | - |
dc.subject | SIGNALING | - |
dc.title | FOXO3a Is Activated in Response to Hypoxic Stress and Inhibits HIF1-Induced Apoptosis via Regulation of CITED2 | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.molcel.2007.10.035 | - |
dc.identifier.pmid | 18158893 | - |
dc.identifier.scopus | eid_2-s2.0-37349025432 | - |
dc.identifier.volume | 28 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 941 | - |
dc.identifier.epage | 953 | - |
dc.identifier.isi | WOS:000252170000003 | - |
dc.identifier.issnl | 1097-2765 | - |