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Article: The p53 family: Guardians of maternal reproduction

TitleThe p53 family: Guardians of maternal reproduction
Authors
Levine, Arnold J.Tomasini, RichardMcKeon, Frank D.Mak, Tak W.Melino, Gerry
Issue Date2011
Citation
Nature Reviews Molecular Cell Biology, 2011, v. 12, n. 4, p. 259-265 How to Cite?
DOI: http://dx.doi.org/10.1038/nrm3086
AbstractThe p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction. © 2011 Macmillan Publishers Limited. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/292022
ISSN
1471-0072
2021 Impact Factor: 113.915
2020 SCImago Journal Rankings: 37.461
ISI Accession Number ID
WOS:000288696700013

 

DC FieldValueLanguage
dc.contributor.authorLevine, Arnold J.-
dc.contributor.authorTomasini, Richard-
dc.contributor.authorMcKeon, Frank D.-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorMelino, Gerry-
dc.date.accessioned2020-11-17T14:55:36Z-
dc.date.available2020-11-17T14:55:36Z-
dc.date.issued2011-
dc.identifier.citationNature Reviews Molecular Cell Biology, 2011, v. 12, n. 4, p. 259-265-
dc.identifier.issn1471-0072-
dc.identifier.urihttp://hdl.handle.net/10722/292022-
dc.description.abstractThe p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction. © 2011 Macmillan Publishers Limited. All rights reserved.-
dc.languageeng-
dc.relation.ispartofNature Reviews Molecular Cell Biology-
dc.titleThe p53 family: Guardians of maternal reproduction-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nrm3086-
dc.identifier.pmid21427767-
dc.identifier.scopuseid_2-s2.0-79953058126-
dc.identifier.volume12-
dc.identifier.issue4-
dc.identifier.spage259-
dc.identifier.epage265-
dc.identifier.eissn1471-0080-
dc.identifier.isiWOS:000288696700013-
dc.identifier.issnl1471-0072-

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