File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.4161/cc.26431
- Scopus: eid_2-s2.0-84887866778
- PMID: 24047696
- WOS: WOS:000327381000013
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR)
Title | Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR) |
---|---|
Authors | |
Keywords | SASP Interleukin 6 Interleukin 6 receptor EGFR mTOR Senescence |
Issue Date | 2013 |
Citation | Cell Cycle, 2013, v. 12, n. 21, p. 3421-3432 How to Cite? |
Abstract | Interleukin 6 (IL-6) signaling plays a role in inflammation, cancer, and senescence. Here, we identified soluble IL-6 receptor (sIL-6R) as a member of the senescence-associated secretory phenotype (SASP). Senescence-associated sIL-6R upregulation was mediated by mammalian target of rapamycin (mTOR). sIL-6R was mainly generated by a disintegrin and metalloprotease 10 (ADAM10)-dependent ectodomain shedding to enable IL-6 trans-signaling. In vivo, heterozygous PTEN-knockout mice exhibited higher mTOR activity and increased sIL-6R levels. Moreover, aberrant EGF receptor (EGFR) activation triggered IL-6 synthesis. In analogy to senescence, EGFR-induced activation of mTOR also induced IL-6R expression and sIL-6R generation. Hence, mTOR activation reprograms IL-6 non-responder cells into IL-6 responder cells. Our data suggest that mTOR serves as a central molecular switch to facilitate cellular IL-6 classic and trans-signaling via IL-6R upregulation with direct implications for cellular senescence and tumor development. © 2013 Landes Bioscience. |
Persistent Identifier | http://hdl.handle.net/10722/292784 |
ISSN | 2021 Impact Factor: 5.173 2020 SCImago Journal Rankings: 1.320 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Garbers, Christoph | - |
dc.contributor.author | Kuck, Fabian | - |
dc.contributor.author | Aparicio-Siegmund, Samadhi | - |
dc.contributor.author | Konzak, Kirstin | - |
dc.contributor.author | Kessenbrock, Mareike | - |
dc.contributor.author | Sommerfeld, Annika | - |
dc.contributor.author | Häussinger, Dieter | - |
dc.contributor.author | Lang, Philipp A. | - |
dc.contributor.author | Brenner, Dirk | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Rose-John, Stefan | - |
dc.contributor.author | Essmann, Frank | - |
dc.contributor.author | Schulze-Osthoff, Klaus | - |
dc.contributor.author | Piekorz, Roland P. | - |
dc.contributor.author | Scheller, Jürgen | - |
dc.date.accessioned | 2020-11-17T14:57:12Z | - |
dc.date.available | 2020-11-17T14:57:12Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Cell Cycle, 2013, v. 12, n. 21, p. 3421-3432 | - |
dc.identifier.issn | 1538-4101 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292784 | - |
dc.description.abstract | Interleukin 6 (IL-6) signaling plays a role in inflammation, cancer, and senescence. Here, we identified soluble IL-6 receptor (sIL-6R) as a member of the senescence-associated secretory phenotype (SASP). Senescence-associated sIL-6R upregulation was mediated by mammalian target of rapamycin (mTOR). sIL-6R was mainly generated by a disintegrin and metalloprotease 10 (ADAM10)-dependent ectodomain shedding to enable IL-6 trans-signaling. In vivo, heterozygous PTEN-knockout mice exhibited higher mTOR activity and increased sIL-6R levels. Moreover, aberrant EGF receptor (EGFR) activation triggered IL-6 synthesis. In analogy to senescence, EGFR-induced activation of mTOR also induced IL-6R expression and sIL-6R generation. Hence, mTOR activation reprograms IL-6 non-responder cells into IL-6 responder cells. Our data suggest that mTOR serves as a central molecular switch to facilitate cellular IL-6 classic and trans-signaling via IL-6R upregulation with direct implications for cellular senescence and tumor development. © 2013 Landes Bioscience. | - |
dc.language | eng | - |
dc.relation.ispartof | Cell Cycle | - |
dc.subject | SASP | - |
dc.subject | Interleukin 6 | - |
dc.subject | Interleukin 6 receptor | - |
dc.subject | EGFR | - |
dc.subject | mTOR | - |
dc.subject | Senescence | - |
dc.title | Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR) | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.4161/cc.26431 | - |
dc.identifier.pmid | 24047696 | - |
dc.identifier.pmcid | PMC3895430 | - |
dc.identifier.scopus | eid_2-s2.0-84887866778 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 21 | - |
dc.identifier.spage | 3421 | - |
dc.identifier.epage | 3432 | - |
dc.identifier.eissn | 1551-4005 | - |
dc.identifier.isi | WOS:000327381000013 | - |
dc.identifier.issnl | 1551-4005 | - |