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- Publisher Website: 10.1111/acel.12274
- Scopus: eid_2-s2.0-84911406431
- PMID: 25257511
- WOS: WOS:000345457900014
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Article: Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response
Title | Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response |
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Authors | |
Keywords | Lysosomes Cryba1 cKO mice, inflammation Age-related macular degeneration Lipocalin-2 Retinal pigment epithelium |
Issue Date | 2014 |
Citation | Aging Cell, 2014, v. 13, n. 6, p. 1091-1094 How to Cite? |
Abstract | Although chronic inflammation is believed to contribute to the pathology of age-related macular degeneration (AMD), knowledge regarding the events that elicit the change from para-inflammation to chronic inflammation in the pathogenesis of AMD is lacking. We propose here that lipocalin-2 (LCN2), a mammalian innate immunity protein that is trafficked to the lysosomes, may contribute to this process. It accumulates significantly with age in retinal pigment epithelial (RPE) cells of Cryba1 conditional knockout (cKO) mice, but not in control mice. We have recently shown that these mice, which lack βA3/A1-crystallin specifically in RPE, have defective lysosomal clearance. The age-related increase in LCN2 in the cKO mice is accompanied by increases in chemokine (C-C motif) ligand 2 (CCL2), reactive gliosis, and immune cell infiltration. LCN2 may contribute to induction of a chronic inflammatory response in this mouse model with AMD-like pathology. |
Persistent Identifier | http://hdl.handle.net/10722/292855 |
ISSN | 2021 Impact Factor: 11.005 2020 SCImago Journal Rankings: 3.103 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Valapala, Mallika | - |
dc.contributor.author | Edwards, Malia | - |
dc.contributor.author | Hose, Stacey | - |
dc.contributor.author | Grebe, Rhonda | - |
dc.contributor.author | Bhutto, Imran A. | - |
dc.contributor.author | Cano, Marisol | - |
dc.contributor.author | Berger, Thorsten | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Wawrousek, Eric | - |
dc.contributor.author | Handa, James T. | - |
dc.contributor.author | Lutty, Gerard A. | - |
dc.contributor.author | Samuel Zigler, J. | - |
dc.contributor.author | Sinha, Debasish | - |
dc.date.accessioned | 2020-11-17T14:57:21Z | - |
dc.date.available | 2020-11-17T14:57:21Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Aging Cell, 2014, v. 13, n. 6, p. 1091-1094 | - |
dc.identifier.issn | 1474-9718 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292855 | - |
dc.description.abstract | Although chronic inflammation is believed to contribute to the pathology of age-related macular degeneration (AMD), knowledge regarding the events that elicit the change from para-inflammation to chronic inflammation in the pathogenesis of AMD is lacking. We propose here that lipocalin-2 (LCN2), a mammalian innate immunity protein that is trafficked to the lysosomes, may contribute to this process. It accumulates significantly with age in retinal pigment epithelial (RPE) cells of Cryba1 conditional knockout (cKO) mice, but not in control mice. We have recently shown that these mice, which lack βA3/A1-crystallin specifically in RPE, have defective lysosomal clearance. The age-related increase in LCN2 in the cKO mice is accompanied by increases in chemokine (C-C motif) ligand 2 (CCL2), reactive gliosis, and immune cell infiltration. LCN2 may contribute to induction of a chronic inflammatory response in this mouse model with AMD-like pathology. | - |
dc.language | eng | - |
dc.relation.ispartof | Aging Cell | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Lysosomes | - |
dc.subject | Cryba1 cKO mice, inflammation | - |
dc.subject | Age-related macular degeneration | - |
dc.subject | Lipocalin-2 | - |
dc.subject | Retinal pigment epithelium | - |
dc.title | Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1111/acel.12274 | - |
dc.identifier.pmid | 25257511 | - |
dc.identifier.pmcid | PMC4244249 | - |
dc.identifier.scopus | eid_2-s2.0-84911406431 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1091 | - |
dc.identifier.epage | 1094 | - |
dc.identifier.eissn | 1474-9726 | - |
dc.identifier.isi | WOS:000345457900014 | - |
dc.identifier.issnl | 1474-9718 | - |