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Article: Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background

TitleData on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background
Authors
Singh, VishalYeoh, Beng SanNilsen-Hamilton, MaritBerger, ThorstenMak, Tak W.Vijay-Kumar, Matam
KeywordsInflammatory bowel disease
Neutrophil gelatinase-associated lipocalin
Siderocalin
IL-10
Issue Date2017
Citation
Data in Brief, 2017, v. 11, p. 588-592 How to Cite?
DOI: http://dx.doi.org/10.1016/j.dib.2017.03.002
AbstractThe data herein is related to the research article entitled “Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis” (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic colitis upon anti-interleukin-10 receptor (αIL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/c Lcn2KO mice and their WT littermates to the αIL-10R neutralization-induced chronic colitis. Our data showed that αIL-10R mAb-treated BALB/c Lcn2KO mice exhibited severe chronic colitis (i.e., splenomegaly, colomegaly, colonic pathology, and incidence of rectal prolapse) when compared to WT mice.
Persistent Identifierhttp://hdl.handle.net/10722/293005
PubMed Central ID
PMC5358532
ISI Accession Number ID
WOS:000453174100089

 

DC FieldValueLanguage
dc.contributor.authorSingh, Vishal-
dc.contributor.authorYeoh, Beng San-
dc.contributor.authorNilsen-Hamilton, Marit-
dc.contributor.authorBerger, Thorsten-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorVijay-Kumar, Matam-
dc.date.accessioned2020-11-17T14:57:40Z-
dc.date.available2020-11-17T14:57:40Z-
dc.date.issued2017-
dc.identifier.citationData in Brief, 2017, v. 11, p. 588-592-
dc.identifier.urihttp://hdl.handle.net/10722/293005-
dc.description.abstractThe data herein is related to the research article entitled “Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis” (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic colitis upon anti-interleukin-10 receptor (αIL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/c Lcn2KO mice and their WT littermates to the αIL-10R neutralization-induced chronic colitis. Our data showed that αIL-10R mAb-treated BALB/c Lcn2KO mice exhibited severe chronic colitis (i.e., splenomegaly, colomegaly, colonic pathology, and incidence of rectal prolapse) when compared to WT mice.-
dc.languageeng-
dc.relation.ispartofData in Brief-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectInflammatory bowel disease-
dc.subjectNeutrophil gelatinase-associated lipocalin-
dc.subjectSiderocalin-
dc.subjectIL-10-
dc.titleData on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.dib.2017.03.002-
dc.identifier.pmid28349107-
dc.identifier.pmcidPMC5358532-
dc.identifier.scopuseid_2-s2.0-85015371216-
dc.identifier.volume11-
dc.identifier.spage588-
dc.identifier.epage592-
dc.identifier.eissn2352-3409-
dc.identifier.isiWOS:000453174100089-
dc.identifier.issnl2352-3409-

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