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Article: S-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells

TitleS-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells
Authors
Xu, XWang, HLi, HHu, XZhang, YGuan, XToy, PHSun, H
Keywordsapoptosis
clinical effectiveness
controlled study
cytotoxicity
drug effect
Issue Date2019
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2019, v. 55 n. 87, p. 13120-13123 How to Cite?
DOI: http://dx.doi.org/10.1039/C9CC07605K
AbstractHistone H3.3 was identified as an arsenic-binding protein of S-dimethylarsino-glutathione (ZIO-101, darinaparsin®) in leukemia cells by GE-ICP-MS. Such a binding results in TRAIL-induced apoptosis. We further validate histone H3.3 as a vital target for ZIO-101, offering new information on the mode of action of arsenic-based anticancer agents.
Persistent Identifierhttp://hdl.handle.net/10722/293268
ISSN
1359-7345
2021 Impact Factor: 6.065
2020 SCImago Journal Rankings: 1.837
ISI Accession Number ID
WOS:000494428800013

 

DC FieldValueLanguage
dc.contributor.authorXu, X-
dc.contributor.authorWang, H-
dc.contributor.authorLi, H-
dc.contributor.authorHu, X-
dc.contributor.authorZhang, Y-
dc.contributor.authorGuan, X-
dc.contributor.authorToy, PH-
dc.contributor.authorSun, H-
dc.date.accessioned2020-11-23T08:14:16Z-
dc.date.available2020-11-23T08:14:16Z-
dc.date.issued2019-
dc.identifier.citationChemical Communications, 2019, v. 55 n. 87, p. 13120-13123-
dc.identifier.issn1359-7345-
dc.identifier.urihttp://hdl.handle.net/10722/293268-
dc.description.abstractHistone H3.3 was identified as an arsenic-binding protein of S-dimethylarsino-glutathione (ZIO-101, darinaparsin®) in leukemia cells by GE-ICP-MS. Such a binding results in TRAIL-induced apoptosis. We further validate histone H3.3 as a vital target for ZIO-101, offering new information on the mode of action of arsenic-based anticancer agents.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp-
dc.relation.ispartofChemical Communications-
dc.subjectapoptosis-
dc.subjectclinical effectiveness-
dc.subjectcontrolled study-
dc.subjectcytotoxicity-
dc.subjectdrug effect-
dc.titleS-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells-
dc.typeArticle-
dc.identifier.emailWang, H: wanghaib@hku.hk-
dc.identifier.emailLi, H: hylichem@hku.hk-
dc.identifier.emailGuan, X: xyguan@hku.hk-
dc.identifier.emailToy, PH: phtoy@hkucc.hku.hk-
dc.identifier.emailSun, H: hsun@hku.hk-
dc.identifier.authorityGuan, X=rp00454-
dc.identifier.authorityToy, PH=rp00791-
dc.identifier.authoritySun, H=rp00777-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/C9CC07605K-
dc.identifier.pmid31616884-
dc.identifier.scopuseid_2-s2.0-85074245700-
dc.identifier.hkuros319808-
dc.identifier.volume55-
dc.identifier.issue87-
dc.identifier.spage13120-
dc.identifier.epage13123-
dc.identifier.isiWOS:000494428800013-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1359-7345-

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