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Article: Proton/heavy ion therapy in salvage of locally recurrent nasopharyngeal carcinoma
Title | Proton/heavy ion therapy in salvage of locally recurrent nasopharyngeal carcinoma |
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Authors | |
Keywords | Nasopharyngeal carcinoma (NPC) local recurrence proton heavy-ion radiotherapy |
Issue Date | 2020 |
Publisher | AME Publishing Company. The Journal's web site is located at https://anpc.amegroups.com/ |
Citation | Annals of Nasopharynx Cancer, 2020, v. 4, p. article no. 4 How to Cite? |
Abstract | Radiotherapy is the major modality for treating advanced local recurrence of nasopharyngeal carcinoma (NPC). However, as the nearby critical neurological structures have already absorbed a dose close to their maximum tolerance in the primary treatment, even state-of-the-art intensity modulated radiotherapy (IMRT) cannot achieve a satisfactory dose distribution, and re-irradiation is often associated with serious, or even fatal, late complication, as well as substantial local failure. Proton/heavy-ion therapy, with their superior energy deposition characteristics and biological effectiveness, have the potential to overcome these obstacles. The use of proton/heavy-ion therapy to treat re-current NPC dates back to the last millennium when such facilities were extremely rare and dose delivery technique was in its infancy (mainly passive-scattered beams from very limited directions were available). Over the last two decades there have been substantial technological development in proton/heavy-ion therapy, the facilities have become much more widely available, with proton therapy being accepted as a suitable mean for re-irradiation setting in general. The advancement in diagnostic technology and systemic treatment have also contributed significantly to the effectiveness of such highly conformal radiotherapy modalities. Many have applied proton/heavy-ion therapy in the extremely challenging recurrent NPC situation, with various degrees of success. This article provides a brief review of the basic principle of proton/heavy-ion therapy, the issues unique to their usage, studies on their application in treating recurrent NPC and their possible future development. |
Persistent Identifier | http://hdl.handle.net/10722/293328 |
ISSN |
DC Field | Value | Language |
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dc.contributor.author | Lee, MCH | - |
dc.contributor.author | Ng, WT | - |
dc.date.accessioned | 2020-11-23T08:15:10Z | - |
dc.date.available | 2020-11-23T08:15:10Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Annals of Nasopharynx Cancer, 2020, v. 4, p. article no. 4 | - |
dc.identifier.issn | 2616-4191 | - |
dc.identifier.uri | http://hdl.handle.net/10722/293328 | - |
dc.description.abstract | Radiotherapy is the major modality for treating advanced local recurrence of nasopharyngeal carcinoma (NPC). However, as the nearby critical neurological structures have already absorbed a dose close to their maximum tolerance in the primary treatment, even state-of-the-art intensity modulated radiotherapy (IMRT) cannot achieve a satisfactory dose distribution, and re-irradiation is often associated with serious, or even fatal, late complication, as well as substantial local failure. Proton/heavy-ion therapy, with their superior energy deposition characteristics and biological effectiveness, have the potential to overcome these obstacles. The use of proton/heavy-ion therapy to treat re-current NPC dates back to the last millennium when such facilities were extremely rare and dose delivery technique was in its infancy (mainly passive-scattered beams from very limited directions were available). Over the last two decades there have been substantial technological development in proton/heavy-ion therapy, the facilities have become much more widely available, with proton therapy being accepted as a suitable mean for re-irradiation setting in general. The advancement in diagnostic technology and systemic treatment have also contributed significantly to the effectiveness of such highly conformal radiotherapy modalities. Many have applied proton/heavy-ion therapy in the extremely challenging recurrent NPC situation, with various degrees of success. This article provides a brief review of the basic principle of proton/heavy-ion therapy, the issues unique to their usage, studies on their application in treating recurrent NPC and their possible future development. | - |
dc.language | eng | - |
dc.publisher | AME Publishing Company. The Journal's web site is located at https://anpc.amegroups.com/ | - |
dc.relation.ispartof | Annals of Nasopharynx Cancer | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Nasopharyngeal carcinoma (NPC) | - |
dc.subject | local recurrence | - |
dc.subject | proton | - |
dc.subject | heavy-ion | - |
dc.subject | radiotherapy | - |
dc.title | Proton/heavy ion therapy in salvage of locally recurrent nasopharyngeal carcinoma | - |
dc.type | Article | - |
dc.identifier.email | Ng, WT: ngwt1@hkucc.hku.hk | - |
dc.identifier.authority | Ng, WT=rp02671 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.21037/anpc-20-7 | - |
dc.identifier.hkuros | 319698 | - |
dc.identifier.volume | 4 | - |
dc.identifier.spage | article no. 4 | - |
dc.identifier.epage | article no. 4 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 2616-4191 | - |