Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.bbrc.2020.04.051
- Scopus: eid_2-s2.0-85083553361
- PMID: 32446389
- WOS: WOS:000535964300007
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: In vitro and in vivo impairment of embryo implantation by commonly used fungicide Mancozeb
Title | In vitro and in vivo impairment of embryo implantation by commonly used fungicide Mancozeb |
---|---|
Authors | |
Keywords | Mancozeb Endocrine disruptor Embryo implantation Decidualization |
Issue Date | 2020 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description |
Citation | Biochemical and Biophysical Research Communications, 2020, v. 527 n. 1, p. 42-48 How to Cite? |
Abstract | The fungicide Mancozeb is an endocrine-disrupting chemical and the mode of action of Mancozeb on embryo implantation is largely unknown. Mancozeb (1 and 3 μg/ml) significantly reduced Jeg-3 trophoblastic spheroids attachment to endometrial epithelial Ishikawa cells. Mancozeb treatment from gestation day (GD) 1 to GD8 or from GD4 to GD8 significantly lowered the number of implantation sites with higher incidence of morphological abnormalities in the reproductive tissues. However, these were not seen in the treatment from GD1 to GD4. Mancozeb at 30 mg/kg BW/d did not alter the expression of p53, COX-2, or PGFS transcripts in the uterus, but down-regulated the PGES transcript and protein. Mancozeb treatment in human endometrial stromal cells did not alter the decidualization response, but the morphological transformation was impaired. Taken together, exposure to Mancozeb affected embryo implantation probably through the modulation of decidualization and to delineate the exact mode of action needs further investigations. |
Persistent Identifier | http://hdl.handle.net/10722/293452 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.770 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Akthar, I | - |
dc.contributor.author | Wang, Z | - |
dc.contributor.author | Wijayagunawardane, MPB | - |
dc.contributor.author | Ratnayake, CJ | - |
dc.contributor.author | Siriweera, EH | - |
dc.contributor.author | Lee, KF | - |
dc.contributor.author | Kodithuwakku, SP | - |
dc.date.accessioned | 2020-11-23T08:16:58Z | - |
dc.date.available | 2020-11-23T08:16:58Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, 2020, v. 527 n. 1, p. 42-48 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10722/293452 | - |
dc.description.abstract | The fungicide Mancozeb is an endocrine-disrupting chemical and the mode of action of Mancozeb on embryo implantation is largely unknown. Mancozeb (1 and 3 μg/ml) significantly reduced Jeg-3 trophoblastic spheroids attachment to endometrial epithelial Ishikawa cells. Mancozeb treatment from gestation day (GD) 1 to GD8 or from GD4 to GD8 significantly lowered the number of implantation sites with higher incidence of morphological abnormalities in the reproductive tissues. However, these were not seen in the treatment from GD1 to GD4. Mancozeb at 30 mg/kg BW/d did not alter the expression of p53, COX-2, or PGFS transcripts in the uterus, but down-regulated the PGES transcript and protein. Mancozeb treatment in human endometrial stromal cells did not alter the decidualization response, but the morphological transformation was impaired. Taken together, exposure to Mancozeb affected embryo implantation probably through the modulation of decidualization and to delineate the exact mode of action needs further investigations. | - |
dc.language | eng | - |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description | - |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Mancozeb | - |
dc.subject | Endocrine disruptor | - |
dc.subject | Embryo implantation | - |
dc.subject | Decidualization | - |
dc.title | In vitro and in vivo impairment of embryo implantation by commonly used fungicide Mancozeb | - |
dc.type | Article | - |
dc.identifier.email | Lee, KF: ckflee@hku.hk | - |
dc.identifier.authority | Lee, KF=rp00458 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.bbrc.2020.04.051 | - |
dc.identifier.pmid | 32446389 | - |
dc.identifier.scopus | eid_2-s2.0-85083553361 | - |
dc.identifier.hkuros | 319507 | - |
dc.identifier.volume | 527 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 42 | - |
dc.identifier.epage | 48 | - |
dc.identifier.isi | WOS:000535964300007 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0006-291X | - |