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Article: Rest‐Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder

TitleRest‐Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder
Authors
Keywordsactimetry
aged
body mass
case control study
circadian rhythm
Issue Date2020
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507645
Citation
Annals of Neurology, 2020, v. 88 n. 4, p. 817-829 How to Cite?
AbstractObjective The purpose of this study was to investigate the differences in actigraphy‐measured rest‐activity patterns (eg, sleep–wake cycle, circadian rest‐activity rhythm, and physical activity) across different stages of α‐synucleinopathy. Methods We compared alterations in 7‐day actigraphy‐measured rest‐activity patterns among patients with clinically diagnosed α‐synucleinopathies (n = 44), and their age‐, sex‐, and body mass index (BMI)‐matched patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD, n = 88), and non‐rapid eye movement (REM) sleep behavior disorder (RBD) controls (n = 44) in a case–control study (study 1) and between convertors (n = 22) and their age‐, sex‐, BMI‐, iRBD‐duration, and follow‐up duration‐matched non‐convertors (n = 66) in a prospective nested case–control study (study 2). Results In study 1, there were significant increases (all p values were adjusted by false discovery rate < 0.01) in probable napping behaviors (percentage, duration, and episodes), activity fragmentation (estimated by kAR), and physical inactivity during active periods across controls, and iRBD, to clinically diagnosed α‐synucleinopathies. In study 2, higher levels (all p values were adjusted by false discovery rate < 0.05) of baseline objective probable napping, activity fragmentation, and physical inactivity during active periods were associated with the conversion of patients with iRBD into clinically diagnosed α‐synucleinopathies at 2 years of follow‐up with medium to large effect sizes (Cohen's d: 0.56 to 0.80). These findings were further supported by functional linear modeling analyses. Interpretation Rest‐activity pattern alterations, mainly objective probable napping behaviors, activity fragmentation, and physical inactivity during active period, emerge as early as at the stage of iRBD, which serves as early and robust prodromal markers of the conversion of iRBD into clinically diagnosed α‐synucleinopathies.
Persistent Identifierhttp://hdl.handle.net/10722/293507
ISSN
2019 Impact Factor: 9.037
2015 SCImago Journal Rankings: 5.584
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFeng, H-
dc.contributor.authorChen, L-
dc.contributor.authorLiu, Y-
dc.contributor.authorChen, X-
dc.contributor.authorWang, J-
dc.contributor.authorYu, MWM-
dc.contributor.authorHuang, B-
dc.contributor.authorLi, SX-
dc.contributor.authorChau, SWH-
dc.contributor.authorChan, JWY-
dc.contributor.authorChen, J-
dc.contributor.authorMok, VCT-
dc.contributor.authorWing, YK-
dc.contributor.authorZhang, J-
dc.date.accessioned2020-11-23T08:17:46Z-
dc.date.available2020-11-23T08:17:46Z-
dc.date.issued2020-
dc.identifier.citationAnnals of Neurology, 2020, v. 88 n. 4, p. 817-829-
dc.identifier.issn0364-5134-
dc.identifier.urihttp://hdl.handle.net/10722/293507-
dc.description.abstractObjective The purpose of this study was to investigate the differences in actigraphy‐measured rest‐activity patterns (eg, sleep–wake cycle, circadian rest‐activity rhythm, and physical activity) across different stages of α‐synucleinopathy. Methods We compared alterations in 7‐day actigraphy‐measured rest‐activity patterns among patients with clinically diagnosed α‐synucleinopathies (n = 44), and their age‐, sex‐, and body mass index (BMI)‐matched patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD, n = 88), and non‐rapid eye movement (REM) sleep behavior disorder (RBD) controls (n = 44) in a case–control study (study 1) and between convertors (n = 22) and their age‐, sex‐, BMI‐, iRBD‐duration, and follow‐up duration‐matched non‐convertors (n = 66) in a prospective nested case–control study (study 2). Results In study 1, there were significant increases (all p values were adjusted by false discovery rate < 0.01) in probable napping behaviors (percentage, duration, and episodes), activity fragmentation (estimated by kAR), and physical inactivity during active periods across controls, and iRBD, to clinically diagnosed α‐synucleinopathies. In study 2, higher levels (all p values were adjusted by false discovery rate < 0.05) of baseline objective probable napping, activity fragmentation, and physical inactivity during active periods were associated with the conversion of patients with iRBD into clinically diagnosed α‐synucleinopathies at 2 years of follow‐up with medium to large effect sizes (Cohen's d: 0.56 to 0.80). These findings were further supported by functional linear modeling analyses. Interpretation Rest‐activity pattern alterations, mainly objective probable napping behaviors, activity fragmentation, and physical inactivity during active period, emerge as early as at the stage of iRBD, which serves as early and robust prodromal markers of the conversion of iRBD into clinically diagnosed α‐synucleinopathies.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507645-
dc.relation.ispartofAnnals of Neurology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectactimetry-
dc.subjectaged-
dc.subjectbody mass-
dc.subjectcase control study-
dc.subjectcircadian rhythm-
dc.titleRest‐Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder-
dc.typeArticle-
dc.identifier.emailLi, SX: shirleyx@hku.hk-
dc.identifier.authorityLi, SX=rp02114-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ana.25853-
dc.identifier.pmid32691442-
dc.identifier.scopuseid_2-s2.0-85089515379-
dc.identifier.hkuros319137-
dc.identifier.volume88-
dc.identifier.issue4-
dc.identifier.spage817-
dc.identifier.epage829-
dc.identifier.isiWOS:000560143800001-
dc.publisher.placeUnited States-
dc.identifier.issnl0364-5134-

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