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Article: Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Peripheral and Central Tumor Necrosis Factor Alpha in Rats with Depression-Chronic Somatic Pain Comorbidity

TitleEffects of Transcutaneous Auricular Vagus Nerve Stimulation on Peripheral and Central Tumor Necrosis Factor Alpha in Rats with Depression-Chronic Somatic Pain Comorbidity
Authors
Issue Date2020
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/np/
Citation
Neural Plasticity, 2020, v. 2020, p. article no. 8885729 How to Cite?
AbstractDepression and pain disorders share a high degree of comorbidity. Inflammatory mechanisms play an important role in the pathogenesis of depression-chronic somatic pain comorbidity. In this study, we investigated the effects of acupuncture on blood and brain regional tumor necrosis factor alpha (TNF-α) in rats with depression and chronic somatic pain comorbidity. Forty Sprague-Dawley rats were randomly divided into the following 4 groups with 10 each: control, model, model treated with transcutaneous auricular vagus nerve stimulation (taVNS), and model treated with electroacupuncture (EA). Chronic unpredictable mild stress (CUMS) with chronic constriction injury of the sciatic nerve (CCI) was used to produce depression and chronic somatic pain comorbidity in the latter 3 groups. The rats of the taVNS and EA groups received, respectively, taVNS and EA at ST 36 for 28 days. Pain intensity was measured using a mechanical withdrawal threshold and thermal stimulation latency once biweekly. Depressive behavior was examined using a sucrose preference test at baseline and the end of modeling and intervention. The level of plasma TNF-α and the expression of TNF-α in the prefrontal cortex (PFC), hippocampus, amygdala, and hypothalamus were measured. While CUMS plus CCI produced remarkable depression-like behavior and pain disorders, EA and taVNS significantly improved depression and reduced pain intensity. CUMS plus CCI also resulted in a significant increase in plasma TNF-α level and the expression in all brain regions examined compared to the intact controls. Both EA and taVNS interventions, however, suppressed the elevated level of TNF-α. These results suggest that EA and taVNS have antidepressant and analgesic effects. Such effects may be associated with the suppression of TNF-α-related neuroinflammation.
Persistent Identifierhttp://hdl.handle.net/10722/293637
ISSN
2020 Impact Factor: 3.599
2020 SCImago Journal Rankings: 1.288
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGuo, X-
dc.contributor.authorZhao, Y-
dc.contributor.authorHuang, F-
dc.contributor.authorLi, S-
dc.contributor.authorLuo, M-
dc.contributor.authorWang, Y-
dc.contributor.authorZhang, J-
dc.contributor.authorLi, L-
dc.contributor.authorZhang, Y-
dc.contributor.authorJiao, Y-
dc.contributor.authorZhao, B-
dc.contributor.authorWang, J-
dc.contributor.authorMeng, H-
dc.contributor.authorZhang, Z-
dc.contributor.authorRong, P-
dc.date.accessioned2020-11-23T08:19:39Z-
dc.date.available2020-11-23T08:19:39Z-
dc.date.issued2020-
dc.identifier.citationNeural Plasticity, 2020, v. 2020, p. article no. 8885729-
dc.identifier.issn2090-5904-
dc.identifier.urihttp://hdl.handle.net/10722/293637-
dc.description.abstractDepression and pain disorders share a high degree of comorbidity. Inflammatory mechanisms play an important role in the pathogenesis of depression-chronic somatic pain comorbidity. In this study, we investigated the effects of acupuncture on blood and brain regional tumor necrosis factor alpha (TNF-α) in rats with depression and chronic somatic pain comorbidity. Forty Sprague-Dawley rats were randomly divided into the following 4 groups with 10 each: control, model, model treated with transcutaneous auricular vagus nerve stimulation (taVNS), and model treated with electroacupuncture (EA). Chronic unpredictable mild stress (CUMS) with chronic constriction injury of the sciatic nerve (CCI) was used to produce depression and chronic somatic pain comorbidity in the latter 3 groups. The rats of the taVNS and EA groups received, respectively, taVNS and EA at ST 36 for 28 days. Pain intensity was measured using a mechanical withdrawal threshold and thermal stimulation latency once biweekly. Depressive behavior was examined using a sucrose preference test at baseline and the end of modeling and intervention. The level of plasma TNF-α and the expression of TNF-α in the prefrontal cortex (PFC), hippocampus, amygdala, and hypothalamus were measured. While CUMS plus CCI produced remarkable depression-like behavior and pain disorders, EA and taVNS significantly improved depression and reduced pain intensity. CUMS plus CCI also resulted in a significant increase in plasma TNF-α level and the expression in all brain regions examined compared to the intact controls. Both EA and taVNS interventions, however, suppressed the elevated level of TNF-α. These results suggest that EA and taVNS have antidepressant and analgesic effects. Such effects may be associated with the suppression of TNF-α-related neuroinflammation.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/np/-
dc.relation.ispartofNeural Plasticity-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleEffects of Transcutaneous Auricular Vagus Nerve Stimulation on Peripheral and Central Tumor Necrosis Factor Alpha in Rats with Depression-Chronic Somatic Pain Comorbidity-
dc.typeArticle-
dc.identifier.emailZhang, Z: zhangzj@hkucc.hku.hk-
dc.identifier.authorityZhang, Z=rp01297-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2020/8885729-
dc.identifier.pmid33144854-
dc.identifier.pmcidPMC7599410-
dc.identifier.hkuros319622-
dc.identifier.volume2020-
dc.identifier.spagearticle no. 8885729-
dc.identifier.epagearticle no. 8885729-
dc.identifier.isiWOS:000591632700001-
dc.publisher.placeUnited States-

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