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Article: Platelet‐activating factor induces acrosome reaction via the activation of extracellular signal‐regulated kinase in human spermatozoa

TitlePlatelet‐activating factor induces acrosome reaction via the activation of extracellular signal‐regulated kinase in human spermatozoa
Authors
Keywordsacrosome reaction
ERK
human spermatozoa
motility
platelet‐activating factor
Issue Date2020
PublisherWiley: 12 months. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AND
Citation
Andrologia, 2020, v. 52 n. 5, p. article no. e13565 How to Cite?
AbstractPlatelet‐activating factor (PAF) affects capacitation, acrosome reaction and fertilisation potential of spermatozoa. This study investigated the underlying mechanism(s) through which PAF regulated sperm function. Our data demonstrated that PAF dose‐dependently induced, whilst lyso‐PAF (PAF precursor) showed no effect on acrosome reaction of capacitated human spermatozoa. Treatment with PAF for 90 min enhanced tyrosine phosphorylation and expression of extracellular signal‐regulated protein kinases (ERK) 1 and 2 in human spermatozoa. Moreover, pre‐treatment with the ERK inhibitor U0126 significantly and dose‐dependently suppressed PAF‐induced acrosome reaction. Therefore, PAF may be actively involved in the modulation of sperm acrosome reaction by interacting with ERK. The role of PAF in fertilisation warrants further investigation.
Persistent Identifierhttp://hdl.handle.net/10722/294303
ISSN
2020 Impact Factor: 2.775
2020 SCImago Journal Rankings: 0.633
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, H-
dc.contributor.authorGao, J-
dc.contributor.authorWANG, X-
dc.contributor.authorLEUNG, TY-
dc.contributor.authorDuan, YG-
dc.contributor.authorChiu, PCN-
dc.date.accessioned2020-11-23T08:29:27Z-
dc.date.available2020-11-23T08:29:27Z-
dc.date.issued2020-
dc.identifier.citationAndrologia, 2020, v. 52 n. 5, p. article no. e13565-
dc.identifier.issn0303-4569-
dc.identifier.urihttp://hdl.handle.net/10722/294303-
dc.description.abstractPlatelet‐activating factor (PAF) affects capacitation, acrosome reaction and fertilisation potential of spermatozoa. This study investigated the underlying mechanism(s) through which PAF regulated sperm function. Our data demonstrated that PAF dose‐dependently induced, whilst lyso‐PAF (PAF precursor) showed no effect on acrosome reaction of capacitated human spermatozoa. Treatment with PAF for 90 min enhanced tyrosine phosphorylation and expression of extracellular signal‐regulated protein kinases (ERK) 1 and 2 in human spermatozoa. Moreover, pre‐treatment with the ERK inhibitor U0126 significantly and dose‐dependently suppressed PAF‐induced acrosome reaction. Therefore, PAF may be actively involved in the modulation of sperm acrosome reaction by interacting with ERK. The role of PAF in fertilisation warrants further investigation.-
dc.languageeng-
dc.publisherWiley: 12 months. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AND-
dc.relation.ispartofAndrologia-
dc.rightsThis is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectacrosome reaction-
dc.subjectERK-
dc.subjecthuman spermatozoa-
dc.subjectmotility-
dc.subjectplatelet‐activating factor-
dc.titlePlatelet‐activating factor induces acrosome reaction via the activation of extracellular signal‐regulated kinase in human spermatozoa-
dc.typeArticle-
dc.identifier.emailChiu, PCN: pchiucn@hku.hk-
dc.identifier.authorityChiu, PCN=rp00424-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/and.13565-
dc.identifier.pmid32187723-
dc.identifier.scopuseid_2-s2.0-85081954362-
dc.identifier.hkuros319345-
dc.identifier.volume52-
dc.identifier.issue5-
dc.identifier.spagearticle no. e13565-
dc.identifier.epagearticle no. e13565-
dc.identifier.isiWOS:000520284900001-
dc.publisher.placeGermany-
dc.identifier.issnl0303-4569-

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