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Article: Single-Atom Catalysts for Biotherapy Applications: A Systematic Review
Title | Single-Atom Catalysts for Biotherapy Applications: A Systematic Review |
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Authors | |
Keywords | single-atom catalysts enzyme-like reactive oxide species biotherapy disease |
Issue Date | 2020 |
Publisher | MDPIAG. The Journal's web site is located at http://www.mdpi.com/journal/nanomaterials |
Citation | Nanomaterials, 2020, v. 10, p. article no. 2518 How to Cite? |
Abstract | Single-atom catalysts (SACs), as atomically dispersed metal active sites anchored or coordinated on suitable supports, demonstrate large potential for use in therapeutic applications. SACs have structural features similar to those of natural enzyme, while exhibiting remarkable catalytic activity, desirable stability, and excellent selectivity. This systematic review aims to synthesize evidence on SACs’ biotherapy applications. Three databases (PubMed/MEDLINE, ISI Web of Science, and ScienceDirect) were searched to identify the studies that investigated the therapeutic efficacy of SACs. A total of 12 studies that fulfilled the inclusion criteria were included and reviewed, and the key findings were qualitatively synthesized. Overall, various SACs were investigated for biotherapy applications, including anticancer, anti-infection (antibacterial), and anti-inflammatory applications; brain trauma therapies, and oxidative-stress cytoprotection applications. All of the included studies showed that the synthesized SACs demonstrated superior therapeutic effects compared with their respective controls. Among the 12 studies reviewed, 11 studies showed satisfied biocompatibility of the applied SACs, whereas minimal cytotoxicity was reported in 1 study. Collectively, the reviewed studies indicated that SACs exhibited considerable promise in the field of biotherapy. Additional studies are needed for a better understanding of the effect of SACs in the treatment of various diseases. |
Persistent Identifier | http://hdl.handle.net/10722/295307 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 0.798 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Jiang, S | - |
dc.contributor.author | Zhang, C | - |
dc.contributor.author | Zou, T | - |
dc.date.accessioned | 2021-01-11T13:58:16Z | - |
dc.date.available | 2021-01-11T13:58:16Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Nanomaterials, 2020, v. 10, p. article no. 2518 | - |
dc.identifier.issn | 2079-4991 | - |
dc.identifier.uri | http://hdl.handle.net/10722/295307 | - |
dc.description.abstract | Single-atom catalysts (SACs), as atomically dispersed metal active sites anchored or coordinated on suitable supports, demonstrate large potential for use in therapeutic applications. SACs have structural features similar to those of natural enzyme, while exhibiting remarkable catalytic activity, desirable stability, and excellent selectivity. This systematic review aims to synthesize evidence on SACs’ biotherapy applications. Three databases (PubMed/MEDLINE, ISI Web of Science, and ScienceDirect) were searched to identify the studies that investigated the therapeutic efficacy of SACs. A total of 12 studies that fulfilled the inclusion criteria were included and reviewed, and the key findings were qualitatively synthesized. Overall, various SACs were investigated for biotherapy applications, including anticancer, anti-infection (antibacterial), and anti-inflammatory applications; brain trauma therapies, and oxidative-stress cytoprotection applications. All of the included studies showed that the synthesized SACs demonstrated superior therapeutic effects compared with their respective controls. Among the 12 studies reviewed, 11 studies showed satisfied biocompatibility of the applied SACs, whereas minimal cytotoxicity was reported in 1 study. Collectively, the reviewed studies indicated that SACs exhibited considerable promise in the field of biotherapy. Additional studies are needed for a better understanding of the effect of SACs in the treatment of various diseases. | - |
dc.language | eng | - |
dc.publisher | MDPIAG. The Journal's web site is located at http://www.mdpi.com/journal/nanomaterials | - |
dc.relation.ispartof | Nanomaterials | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | single-atom catalysts | - |
dc.subject | enzyme-like | - |
dc.subject | reactive oxide species | - |
dc.subject | biotherapy | - |
dc.subject | disease | - |
dc.title | Single-Atom Catalysts for Biotherapy Applications: A Systematic Review | - |
dc.type | Article | - |
dc.identifier.email | Zhang, C: zhangcf@hku.hk | - |
dc.identifier.email | Zou, T: zouting6@hku.hk | - |
dc.identifier.authority | Zhang, C=rp01408 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/nano10122518 | - |
dc.identifier.pmid | 33333964 | - |
dc.identifier.pmcid | PMC7765387 | - |
dc.identifier.scopus | eid_2-s2.0-85097922510 | - |
dc.identifier.hkuros | 320879 | - |
dc.identifier.volume | 10 | - |
dc.identifier.spage | article no. 2518 | - |
dc.identifier.epage | article no. 2518 | - |
dc.identifier.isi | WOS:000602597300001 | - |
dc.publisher.place | Switzerland | - |