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Article: Aspirin Use and Risk of Colorectal Cancer Among Older Adults

TitleAspirin Use and Risk of Colorectal Cancer Among Older Adults
Authors
Issue Date2021
PublisherAmerican Medical Association. The Journal's web site is located at http://oncology.jamanetwork.com/journal.aspx
Citation
JAMA Oncology, 2021, v. 7 n. 3, p. 428-435 How to Cite?
AbstractImportance Although aspirin is recommended for the prevention of colorectal cancer (CRC) among adults aged 50 to 59 years, recent data from a randomized clinical trial suggest a lack of benefit and even possible harm among older adults. Objective To examine the association between aspirin use and the risk of incident CRC among older adults. Design, Setting, and Participants A pooled analysis was conducted of 2 large US cohort studies, the Nurses’ Health Study (June 1, 1980–June 30, 2014) and Health Professionals Follow-up Study (January 1, 1986–January 31, 2014). A total of 94 540 participants aged 70 years or older were included and followed up to June 30, 2014, for women or January 31, 2014, for men. Participants with a diagnosis of any cancer, except nonmelanoma skin cancer, or inflammatory bowel disease were excluded. Statistical analyses were conducted from December 2019 to October 2020. Main Outcomes and Measures Cox proportional hazards models were used to calculate multivariable adjusted hazard ratios (HRs) and 95% CIs for incident CRC. Results Among the 94 540 participants (mean [SD] age, 76.4 [4.9] years for women, 77.7 [5.6] years for men; 67 223 women [71.1%]; 65 259 White women [97.1%], 24 915 White men [96.0%]) aged 70 years or older, 1431 incident cases of CRC were documented over 996 463 person-years of follow-up. After adjustment for other risk factors, regular use of aspirin was associated with a significantly lower risk of CRC at or after age 70 years compared with nonregular use (HR, 0.80; 95% CI, 0.72-0.90). However, the inverse association was evident only among aspirin users who initiated aspirin use before age 70 years (HR, 0.80; 95% CI, 0.67-0.95). In contrast, initiating aspirin use at or after 70 years was not significantly associated with a lower risk of CRC (HR, 0.92; 95% CI, 0.76-1.11). Conclusions and Relevance Initiating aspirin at an older age was not associated with a lower risk of CRC in this pooled analysis of 2 cohort studies. In contrast, those who used aspirin before age 70 years and continued into their 70s or later had a reduced risk of CRC.
Persistent Identifierhttp://hdl.handle.net/10722/295904
ISSN
2020 Impact Factor: 31.777
2020 SCImago Journal Rankings: 8.846
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGUO, CG-
dc.contributor.authorMa, W-
dc.contributor.authorDrew, DA-
dc.contributor.authorCao, Y-
dc.contributor.authorNguyen, LH-
dc.contributor.authorJoshi, AD-
dc.contributor.authorNg, K-
dc.contributor.authorOgino, S-
dc.contributor.authorMeyerhardt, JA-
dc.contributor.authorSong, M-
dc.contributor.authorLeung, WK-
dc.contributor.authorGiovannucci, EL-
dc.contributor.authorChan, AT-
dc.date.accessioned2021-02-08T08:15:41Z-
dc.date.available2021-02-08T08:15:41Z-
dc.date.issued2021-
dc.identifier.citationJAMA Oncology, 2021, v. 7 n. 3, p. 428-435-
dc.identifier.issn2374-2437-
dc.identifier.urihttp://hdl.handle.net/10722/295904-
dc.description.abstractImportance Although aspirin is recommended for the prevention of colorectal cancer (CRC) among adults aged 50 to 59 years, recent data from a randomized clinical trial suggest a lack of benefit and even possible harm among older adults. Objective To examine the association between aspirin use and the risk of incident CRC among older adults. Design, Setting, and Participants A pooled analysis was conducted of 2 large US cohort studies, the Nurses’ Health Study (June 1, 1980–June 30, 2014) and Health Professionals Follow-up Study (January 1, 1986–January 31, 2014). A total of 94 540 participants aged 70 years or older were included and followed up to June 30, 2014, for women or January 31, 2014, for men. Participants with a diagnosis of any cancer, except nonmelanoma skin cancer, or inflammatory bowel disease were excluded. Statistical analyses were conducted from December 2019 to October 2020. Main Outcomes and Measures Cox proportional hazards models were used to calculate multivariable adjusted hazard ratios (HRs) and 95% CIs for incident CRC. Results Among the 94 540 participants (mean [SD] age, 76.4 [4.9] years for women, 77.7 [5.6] years for men; 67 223 women [71.1%]; 65 259 White women [97.1%], 24 915 White men [96.0%]) aged 70 years or older, 1431 incident cases of CRC were documented over 996 463 person-years of follow-up. After adjustment for other risk factors, regular use of aspirin was associated with a significantly lower risk of CRC at or after age 70 years compared with nonregular use (HR, 0.80; 95% CI, 0.72-0.90). However, the inverse association was evident only among aspirin users who initiated aspirin use before age 70 years (HR, 0.80; 95% CI, 0.67-0.95). In contrast, initiating aspirin use at or after 70 years was not significantly associated with a lower risk of CRC (HR, 0.92; 95% CI, 0.76-1.11). Conclusions and Relevance Initiating aspirin at an older age was not associated with a lower risk of CRC in this pooled analysis of 2 cohort studies. In contrast, those who used aspirin before age 70 years and continued into their 70s or later had a reduced risk of CRC.-
dc.languageeng-
dc.publisherAmerican Medical Association. The Journal's web site is located at http://oncology.jamanetwork.com/journal.aspx-
dc.relation.ispartofJAMA Oncology-
dc.titleAspirin Use and Risk of Colorectal Cancer Among Older Adults-
dc.typeArticle-
dc.identifier.emailLeung, WK: waikleung@hku.hk-
dc.identifier.authorityLeung, WK=rp01479-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1001/jamaoncol.2020.7338-
dc.identifier.pmid33475710-
dc.identifier.pmcidPMC7821085-
dc.identifier.hkuros321166-
dc.identifier.volume7-
dc.identifier.issue3-
dc.identifier.spage428-
dc.identifier.epage435-
dc.identifier.isiWOS:000609545200003-
dc.publisher.placeUnited States-

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