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Article: Isolation, purification, identification of structure and study of bioactivity of anti-TB active component 9005B

TitleIsolation, purification, identification of structure and study of bioactivity of anti-TB active component 9005B
Authors
Zhang, ZhangGao, PengGuan, YanXiao, Chun LinHao, Xue Qin
KeywordsIsolation and purification
Anti-TB compounds
DNA gyrase
Actinomycin
Issue Date2009
Citation
Chinese Journal of Antibiotics, 2009, v. 34, n. 7, p. 399-402 How to Cite?
AbstractIn order to study anti-TB constituents from the fermentation broth of Actinomycete strain 9005, the separation procedure was guided by antibacterial bioassay. The compound 9005 B was isolated and purified by column chromatography, and its structrue was identified as actinomycin X by physicochemical properties and spectral data. MIC of the compound 9005B against Mycobacterium tuberculosis H37Rv determined by rapid quantitative microplate (MABA) is 64μg/ml. The anti-TB bioactivity of the compound 9005B is firstly reported. 2
Persistent Identifierhttp://hdl.handle.net/10722/298427
ISSN
1001-8689

 

DC FieldValueLanguage
dc.contributor.authorZhang, Zhang-
dc.contributor.authorGao, Peng-
dc.contributor.authorGuan, Yan-
dc.contributor.authorXiao, Chun Lin-
dc.contributor.authorHao, Xue Qin-
dc.date.accessioned2021-04-08T03:08:23Z-
dc.date.available2021-04-08T03:08:23Z-
dc.date.issued2009-
dc.identifier.citationChinese Journal of Antibiotics, 2009, v. 34, n. 7, p. 399-402-
dc.identifier.issn1001-8689-
dc.identifier.urihttp://hdl.handle.net/10722/298427-
dc.description.abstractIn order to study anti-TB constituents from the fermentation broth of Actinomycete strain 9005, the separation procedure was guided by antibacterial bioassay. The compound 9005 B was isolated and purified by column chromatography, and its structrue was identified as actinomycin X by physicochemical properties and spectral data. MIC of the compound 9005B against Mycobacterium tuberculosis H37Rv determined by rapid quantitative microplate (MABA) is 64μg/ml. The anti-TB bioactivity of the compound 9005B is firstly reported. 2-
dc.languageeng-
dc.relation.ispartofChinese Journal of Antibiotics-
dc.subjectIsolation and purification-
dc.subjectAnti-TB compounds-
dc.subjectDNA gyrase-
dc.subjectActinomycin-
dc.titleIsolation, purification, identification of structure and study of bioactivity of anti-TB active component 9005B-
dc.typeArticle-
dc.identifier.scopuseid_2-s2.0-70350064145-
dc.identifier.volume34-
dc.identifier.issue7-
dc.identifier.spage399-
dc.identifier.epage402-
dc.identifier.issnl1001-8689-

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