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Article: A Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment

TitleA Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment
Authors
Huang, XHuang, PHuang, LHu, ZLiu, XShen, JXi, YYang, YFu, YTao, QLin, SXu, AXu, FXue, TSo, KFLi, HRen, C
Issue Date2021
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/neuron
Citation
Neuron, 2021, v. 109 n. 2, p. 347-362.e7 How to Cite?
DOI: http://dx.doi.org/10.1016/j.neuron.2020.10.023
AbstractLight exerts profound effects on cognitive functions across species, including humans. However, the neuronal mechanisms underlying the effects of light on cognitive functions are poorly understood. In this study, we show that long-term exposure to bright-light treatment promotes spatial memory through a di-synaptic visual circuit related to the nucleus reuniens (Re). Specifically, a subset of SMI-32-expressing ON-type retinal ganglion cells (RGCs) innervate CaMKIIα neurons in the thalamic ventral lateral geniculate nucleus and intergeniculate leaflet (vLGN/IGL), which in turn activate CaMKIIα neurons in the Re. Specific activation of vLGN/IGL-projecting RGCs, activation of Re-projecting vLGN/IGL neurons, or activation of postsynaptic Re neurons is sufficient to promote spatial memory. Furthermore, we demonstrate that the spatial-memory-promoting effects of light treatment are dependent on the activation of vLGN/IGL-projecting RGCs, Re-projecting vLGN/IGL neurons, and Re neurons. Our results reveal a dedicated subcortical visual circuit that mediates the spatial-memory-promoting effects of light treatment.
Persistent Identifierhttp://hdl.handle.net/10722/298678
ISSN
0896-6273
2021 Impact Factor: 18.688
2020 SCImago Journal Rankings: 9.612
ISI Accession Number ID
WOS:000613535400002

 

DC FieldValueLanguage
dc.contributor.authorHuang, X-
dc.contributor.authorHuang, P-
dc.contributor.authorHuang, L-
dc.contributor.authorHu, Z-
dc.contributor.authorLiu, X-
dc.contributor.authorShen, J-
dc.contributor.authorXi, Y-
dc.contributor.authorYang, Y-
dc.contributor.authorFu, Y-
dc.contributor.authorTao, Q-
dc.contributor.authorLin, S-
dc.contributor.authorXu, A-
dc.contributor.authorXu, F-
dc.contributor.authorXue, T-
dc.contributor.authorSo, KF-
dc.contributor.authorLi, H-
dc.contributor.authorRen, C-
dc.date.accessioned2021-04-12T03:01:52Z-
dc.date.available2021-04-12T03:01:52Z-
dc.date.issued2021-
dc.identifier.citationNeuron, 2021, v. 109 n. 2, p. 347-362.e7-
dc.identifier.issn0896-6273-
dc.identifier.urihttp://hdl.handle.net/10722/298678-
dc.description.abstractLight exerts profound effects on cognitive functions across species, including humans. However, the neuronal mechanisms underlying the effects of light on cognitive functions are poorly understood. In this study, we show that long-term exposure to bright-light treatment promotes spatial memory through a di-synaptic visual circuit related to the nucleus reuniens (Re). Specifically, a subset of SMI-32-expressing ON-type retinal ganglion cells (RGCs) innervate CaMKIIα neurons in the thalamic ventral lateral geniculate nucleus and intergeniculate leaflet (vLGN/IGL), which in turn activate CaMKIIα neurons in the Re. Specific activation of vLGN/IGL-projecting RGCs, activation of Re-projecting vLGN/IGL neurons, or activation of postsynaptic Re neurons is sufficient to promote spatial memory. Furthermore, we demonstrate that the spatial-memory-promoting effects of light treatment are dependent on the activation of vLGN/IGL-projecting RGCs, Re-projecting vLGN/IGL neurons, and Re neurons. Our results reveal a dedicated subcortical visual circuit that mediates the spatial-memory-promoting effects of light treatment.-
dc.languageeng-
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/neuron-
dc.relation.ispartofNeuron-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleA Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment-
dc.typeArticle-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.authoritySo, KF=rp00329-
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.neuron.2020.10.023-
dc.identifier.pmid33171117-
dc.identifier.scopuseid_2-s2.0-85096881262-
dc.identifier.hkuros321985-
dc.identifier.volume109-
dc.identifier.issue2-
dc.identifier.spage347-
dc.identifier.epage362.e7-
dc.identifier.isiWOS:000613535400002-
dc.publisher.placeUnited States-

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