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Article: An in-vitro study of subretinal perfluorocarbon liquid (PFCL) droplets and the physics of their retention and evacuation

TitleAn in-vitro study of subretinal perfluorocarbon liquid (PFCL) droplets and the physics of their retention and evacuation
Authors
Chan, YKLaybourne, JPNg, COSaha, CYap, HPYChandra, ASteel, DHSandinha, MTWong, D
KeywordsLaplace pressure
optical coherence tomography (OCT)
perfluorocarbon liquid (PFCL)
Poiseuille’s formula
Sampson’s formula
Issue Date2021
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1755-375X&site=1
Citation
Acta Ophthalmologica, 2021, Epub 2021-03-05 How to Cite?
DOI: http://dx.doi.org/10.1111/aos.14832
AbstractPurpose: To investigate the physics associated with the retention and removal of subretinal perfluorocarbon liquid (PFCL), as inspired by a series of anecdotal cases of spontaneous 'disappearance' of subretinal PFCL. Methods: The profiles of subretinal PFCL in situ from published OCT images were studied and compared with that of PFCL droplets resting on a hydrophilic surface in vitro. A mathematical model based on Sampson's and Poiseuille's formula was developed to explain how evacuation of subretinal PFCL without aspiration could occur. Results: The mathematical model suggested that in vivo subretinal PFCL can completely evacuate in less than a second via a 41-guage retinal hole. Perfluorocarbon liquid (PFCL) droplets in situ subretinally substantially varied in their aspect ratios (from 0.28 to 2.71) and their contact angles with the retinal pigment epithelium (from 98 degrees to 155 degrees). Conversely, PFCL in vitro had aspect ratios and contact angles close to 1 and 150 degrees respectively. Conclusion: This study showed evidence that stretching of the retina to accommodate subretinal PFCL occurs, which might be responsible for the varied profile of the droplets and resultant forces that can cause retinal holes, and spontaneous evacuation of large PFCL droplets. By filling the vitreous cavity with PFCL, a small retinotomy alone might allow spontaneous evacuation without the need for aspiration.
Persistent Identifierhttp://hdl.handle.net/10722/299686
ISSN
1755-375X
2021 Impact Factor: 3.988
2020 SCImago Journal Rankings: 1.534
ISI Accession Number ID
WOS:000625398100001

 

DC FieldValueLanguage
dc.contributor.authorChan, YK-
dc.contributor.authorLaybourne, JP-
dc.contributor.authorNg, CO-
dc.contributor.authorSaha, C-
dc.contributor.authorYap, HPY-
dc.contributor.authorChandra, A-
dc.contributor.authorSteel, DH-
dc.contributor.authorSandinha, MT-
dc.contributor.authorWong, D-
dc.date.accessioned2021-05-26T03:27:38Z-
dc.date.available2021-05-26T03:27:38Z-
dc.date.issued2021-
dc.identifier.citationActa Ophthalmologica, 2021, Epub 2021-03-05-
dc.identifier.issn1755-375X-
dc.identifier.urihttp://hdl.handle.net/10722/299686-
dc.description.abstractPurpose: To investigate the physics associated with the retention and removal of subretinal perfluorocarbon liquid (PFCL), as inspired by a series of anecdotal cases of spontaneous 'disappearance' of subretinal PFCL. Methods: The profiles of subretinal PFCL in situ from published OCT images were studied and compared with that of PFCL droplets resting on a hydrophilic surface in vitro. A mathematical model based on Sampson's and Poiseuille's formula was developed to explain how evacuation of subretinal PFCL without aspiration could occur. Results: The mathematical model suggested that in vivo subretinal PFCL can completely evacuate in less than a second via a 41-guage retinal hole. Perfluorocarbon liquid (PFCL) droplets in situ subretinally substantially varied in their aspect ratios (from 0.28 to 2.71) and their contact angles with the retinal pigment epithelium (from 98 degrees to 155 degrees). Conversely, PFCL in vitro had aspect ratios and contact angles close to 1 and 150 degrees respectively. Conclusion: This study showed evidence that stretching of the retina to accommodate subretinal PFCL occurs, which might be responsible for the varied profile of the droplets and resultant forces that can cause retinal holes, and spontaneous evacuation of large PFCL droplets. By filling the vitreous cavity with PFCL, a small retinotomy alone might allow spontaneous evacuation without the need for aspiration.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1755-375X&site=1-
dc.relation.ispartofActa Ophthalmologica-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectLaplace pressure-
dc.subjectoptical coherence tomography (OCT)-
dc.subjectperfluorocarbon liquid (PFCL)-
dc.subjectPoiseuille’s formula-
dc.subjectSampson’s formula-
dc.titleAn in-vitro study of subretinal perfluorocarbon liquid (PFCL) droplets and the physics of their retention and evacuation-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/aos.14832-
dc.identifier.pmid33666371-
dc.identifier.scopuseid_2-s2.0-85102000290-
dc.identifier.hkuros322474-
dc.identifier.volumeEpub 2021-03-05-
dc.identifier.isiWOS:000625398100001-
dc.publisher.placeUnited States-

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