File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein

TitleSynthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein
Authors
Tian, BaoheHe, MeiziTang, ShixingHewlett, IndiraTan, ZhiwuLi, JieboJin, YinxueYang, Ming
KeywordsSynthesis
Acylhydrazones
HIV-1 capsid
Antiviral activity
Issue Date2009
Citation
Bioorganic and Medicinal Chemistry Letters, 2009, v. 19, n. 8, p. 2162-2167 How to Cite?
DOI: http://dx.doi.org/10.1016/j.bmcl.2009.02.116
AbstractHIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC values of 0.21 and 0.17 μΜ, respectively. © 2009 Elsevier Ltd. All rights reserved. 50
Persistent Identifierhttp://hdl.handle.net/10722/300161
ISSN
0960-894X
2021 Impact Factor: 2.940
2020 SCImago Journal Rankings: 0.617
ISI Accession Number ID
WOS:000264706800015

 

DC FieldValueLanguage
dc.contributor.authorTian, Baohe-
dc.contributor.authorHe, Meizi-
dc.contributor.authorTang, Shixing-
dc.contributor.authorHewlett, Indira-
dc.contributor.authorTan, Zhiwu-
dc.contributor.authorLi, Jiebo-
dc.contributor.authorJin, Yinxue-
dc.contributor.authorYang, Ming-
dc.date.accessioned2021-06-04T05:49:10Z-
dc.date.available2021-06-04T05:49:10Z-
dc.date.issued2009-
dc.identifier.citationBioorganic and Medicinal Chemistry Letters, 2009, v. 19, n. 8, p. 2162-2167-
dc.identifier.issn0960-894X-
dc.identifier.urihttp://hdl.handle.net/10722/300161-
dc.description.abstractHIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC values of 0.21 and 0.17 μΜ, respectively. © 2009 Elsevier Ltd. All rights reserved. 50-
dc.languageeng-
dc.relation.ispartofBioorganic and Medicinal Chemistry Letters-
dc.subjectSynthesis-
dc.subjectAcylhydrazones-
dc.subjectHIV-1 capsid-
dc.subjectAntiviral activity-
dc.titleSynthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bmcl.2009.02.116-
dc.identifier.pmid19297155-
dc.identifier.scopuseid_2-s2.0-63149164406-
dc.identifier.volume19-
dc.identifier.issue8-
dc.identifier.spage2162-
dc.identifier.epage2167-
dc.identifier.isiWOS:000264706800015-

Export via OAI-PMH Interface in XML Formats

OR

Export to Other Non-XML Formats