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Article: SAR and molecular mechanism study of novel acylhydrazone compounds targeting HIV-1 CA

TitleSAR and molecular mechanism study of novel acylhydrazone compounds targeting HIV-1 CA
Authors
Jin, YinxueTan, ZhiwuHe, MeiziTian, BaoheTang, ShixingHewlett, IndiraYang, Ming
KeywordsAntiviral
HIV-1
Acylhydrazone derivatives
Capsid assembly
Issue Date2010
Citation
Bioorganic and Medicinal Chemistry, 2010, v. 18, n. 6, p. 2135-2140 How to Cite?
DOI: http://dx.doi.org/10.1016/j.bmc.2010.02.003
AbstractWe synthesized a series of acylhydrazone compounds bearing naturally occurring amino acids' side chains as HIV assembly inhibitors. Biological evaluation indicated that the compounds had anti-SIV and capsid assembly inhibitory activities. The structure-activity relationship (SAR) study showed that compounds bearing proper aromatic side chains had potential antiviral activities. The molecular modeling experiments revealed the molecular mechanism that they could bind to CA in the same manner as CAP-1 and occupy two more grooves. © 2010.
Persistent Identifierhttp://hdl.handle.net/10722/300163
ISSN
0968-0896
2021 Impact Factor: 3.461
2020 SCImago Journal Rankings: 0.721
ISI Accession Number ID
WOS:000275513700009

 

DC FieldValueLanguage
dc.contributor.authorJin, Yinxue-
dc.contributor.authorTan, Zhiwu-
dc.contributor.authorHe, Meizi-
dc.contributor.authorTian, Baohe-
dc.contributor.authorTang, Shixing-
dc.contributor.authorHewlett, Indira-
dc.contributor.authorYang, Ming-
dc.date.accessioned2021-06-04T05:49:11Z-
dc.date.available2021-06-04T05:49:11Z-
dc.date.issued2010-
dc.identifier.citationBioorganic and Medicinal Chemistry, 2010, v. 18, n. 6, p. 2135-2140-
dc.identifier.issn0968-0896-
dc.identifier.urihttp://hdl.handle.net/10722/300163-
dc.description.abstractWe synthesized a series of acylhydrazone compounds bearing naturally occurring amino acids' side chains as HIV assembly inhibitors. Biological evaluation indicated that the compounds had anti-SIV and capsid assembly inhibitory activities. The structure-activity relationship (SAR) study showed that compounds bearing proper aromatic side chains had potential antiviral activities. The molecular modeling experiments revealed the molecular mechanism that they could bind to CA in the same manner as CAP-1 and occupy two more grooves. © 2010.-
dc.languageeng-
dc.relation.ispartofBioorganic and Medicinal Chemistry-
dc.subjectAntiviral-
dc.subjectHIV-1-
dc.subjectAcylhydrazone derivatives-
dc.subjectCapsid assembly-
dc.titleSAR and molecular mechanism study of novel acylhydrazone compounds targeting HIV-1 CA-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bmc.2010.02.003-
dc.identifier.pmid20188575-
dc.identifier.scopuseid_2-s2.0-77649235297-
dc.identifier.volume18-
dc.identifier.issue6-
dc.identifier.spage2135-
dc.identifier.epage2140-
dc.identifier.isiWOS:000275513700009-

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