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- Publisher Website: 10.1038/s41419-020-2734-3
- Scopus: eid_2-s2.0-85087792138
- PMID: 32655141
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Article: Transamniotic mesenchymal stem cell therapy for neural tube defects preserves neural function through lesion-specific engraftment and regeneration
Title | Transamniotic mesenchymal stem cell therapy for neural tube defects preserves neural function through lesion-specific engraftment and regeneration |
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Authors | |
Issue Date | 2020 |
Publisher | Nature Publishing Group: Open Access Journals. The Journal's web site is located at http://www.nature.com/cddis/index.html |
Citation | Cell Death & Disease, 2020, v. 11, p. article no. 523 How to Cite? |
Abstract | Neural tube defects (NTDs) lead to prenatal mortality and lifelong morbidity. Currently, surgical closure of NTD lesions results in limited functional recovery. We previously suggested that nerve regeneration was critical for NTD therapy. Here, we report that transamniotic bone marrow-derived mesenchymal stem cell (BMSC) therapy for NTDs during early development may achieve beneficial functional recovery. In our ex vivo rat embryonic NTD model, BMSCs injected into the amniotic cavity spontaneously migrated into the defective neural tissue. Hepatocyte growth factor and its receptor c-MET were found to play critical roles in this NTD lesion-specific migration. Using the in vivo rat fetal NTD model, we further discovered that the engrafted BMSCs specifically differentiated into the cell types of the defective tissue, including skin and different types of neurons in situ. BMSC treatment triggered skin repair in fetuses, leading to a 29.9 ± 5.6% reduction in the skin lesion area. The electrophysiological functional recovery assay revealed a decreased latency and increased motor-evoked potential amplitude in the BMSC-treated fetuses. Based on these positive outcomes, ease of operation, and reduced trauma to the mother and fetus, we propose that transamniotic BMSC administration could be a new effective therapy for NTDs. |
Persistent Identifier | http://hdl.handle.net/10722/302122 |
ISSN | 2023 Impact Factor: 8.1 2023 SCImago Journal Rankings: 2.447 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wei, XW | - |
dc.contributor.author | Ma, W | - |
dc.contributor.author | Gu, H | - |
dc.contributor.author | Liu, D | - |
dc.contributor.author | Luo, W | - |
dc.contributor.author | Bai, Y | - |
dc.contributor.author | Wang, W | - |
dc.contributor.author | Lui, VCH | - |
dc.contributor.author | Yang, P | - |
dc.contributor.author | Yuan, Z | - |
dc.date.accessioned | 2021-08-21T03:31:54Z | - |
dc.date.available | 2021-08-21T03:31:54Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Cell Death & Disease, 2020, v. 11, p. article no. 523 | - |
dc.identifier.issn | 2041-4889 | - |
dc.identifier.uri | http://hdl.handle.net/10722/302122 | - |
dc.description.abstract | Neural tube defects (NTDs) lead to prenatal mortality and lifelong morbidity. Currently, surgical closure of NTD lesions results in limited functional recovery. We previously suggested that nerve regeneration was critical for NTD therapy. Here, we report that transamniotic bone marrow-derived mesenchymal stem cell (BMSC) therapy for NTDs during early development may achieve beneficial functional recovery. In our ex vivo rat embryonic NTD model, BMSCs injected into the amniotic cavity spontaneously migrated into the defective neural tissue. Hepatocyte growth factor and its receptor c-MET were found to play critical roles in this NTD lesion-specific migration. Using the in vivo rat fetal NTD model, we further discovered that the engrafted BMSCs specifically differentiated into the cell types of the defective tissue, including skin and different types of neurons in situ. BMSC treatment triggered skin repair in fetuses, leading to a 29.9 ± 5.6% reduction in the skin lesion area. The electrophysiological functional recovery assay revealed a decreased latency and increased motor-evoked potential amplitude in the BMSC-treated fetuses. Based on these positive outcomes, ease of operation, and reduced trauma to the mother and fetus, we propose that transamniotic BMSC administration could be a new effective therapy for NTDs. | - |
dc.language | eng | - |
dc.publisher | Nature Publishing Group: Open Access Journals. The Journal's web site is located at http://www.nature.com/cddis/index.html | - |
dc.relation.ispartof | Cell Death & Disease | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Transamniotic mesenchymal stem cell therapy for neural tube defects preserves neural function through lesion-specific engraftment and regeneration | - |
dc.type | Article | - |
dc.identifier.email | Lui, VCH: vchlui@hku.hk | - |
dc.identifier.authority | Lui, VCH=rp00363 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41419-020-2734-3 | - |
dc.identifier.pmid | 32655141 | - |
dc.identifier.pmcid | PMC7354991 | - |
dc.identifier.scopus | eid_2-s2.0-85087792138 | - |
dc.identifier.hkuros | 324467 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | article no. 523 | - |
dc.identifier.epage | article no. 523 | - |
dc.identifier.isi | WOS:000552643300001 | - |
dc.publisher.place | United Kingdom | - |