File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Association of a composite score of relative grip strength and timed up and go test with incident type 2 diabetes mellitus: Guangzhou Biobank Cohort Study

TitleAssociation of a composite score of relative grip strength and timed up and go test with incident type 2 diabetes mellitus: Guangzhou Biobank Cohort Study
Authors
KeywordsRGS-TUG score
relative grip strength
timed up and go test
incident type 2 diabetes mellitus
Issue Date2021
PublisherImpact Journals LLC. The Journal's web site is located at http://www.impactaging.com
Citation
Aging, 2021, v. 13 n. 14, p. 18376-18391 How to Cite?
AbstractBackground: We investigated association of a score incorporating relative grip strength (RGS) and timed up and go (TUG) test with incident type 2 diabetes mellitus (T2DM) in older Chinese. Methods: Both RGS and TUG scores were classified into tertiles (0~2 points) and summed to yield RGS-TUG score, ranging from 0 to 4 points, with higher points indicating better physical function. Cox proportional hazards regression was used to analyze association of RGS-TUG score with incident T2DM. Results: 3,892 participants without T2DM were followed up for an average of 3.6 years with 240 developing T2DM. After adjustment, those with the lowest RGS-TUG score, versus the highest, had higher fasting glucose, two-hour post-load glucose and glycosylated hemoglobin A1c, with β (95% confidence interval (CI)) being 0.21 (0.08, 0.33), 1.06 (0.69, 1.43) and 0.16 (0.06, 0.27), respectively. In participants with BMI of ≥25 kg/m2, those with the lowest RGS-TUG score showed a higher risk of T2DM (adjusted hazard ratio 3.01, 95% CI 1.04–8.69). No association was found for BMI of 18.5~<25 kg/m2 (P for interaction < 0.05). Conclusions: This is the first study showing lower RGS-TUG score was associated with increased glycemia and incident T2DM in older people with overweight/obesity. The underlying mechanisms warrant further investigation.
Persistent Identifierhttp://hdl.handle.net/10722/302326
ISSN
2020 Impact Factor: 5.682
2020 SCImago Journal Rankings: 1.473
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLiang, X-
dc.contributor.authorJiang, CQ-
dc.contributor.authorZhang, WS-
dc.contributor.authorZhu, F-
dc.contributor.authorJin, YL-
dc.contributor.authorCheng, KK-
dc.contributor.authorLam, TH-
dc.contributor.authorXu, L-
dc.date.accessioned2021-09-06T03:30:41Z-
dc.date.available2021-09-06T03:30:41Z-
dc.date.issued2021-
dc.identifier.citationAging, 2021, v. 13 n. 14, p. 18376-18391-
dc.identifier.issn1945-4589-
dc.identifier.urihttp://hdl.handle.net/10722/302326-
dc.description.abstractBackground: We investigated association of a score incorporating relative grip strength (RGS) and timed up and go (TUG) test with incident type 2 diabetes mellitus (T2DM) in older Chinese. Methods: Both RGS and TUG scores were classified into tertiles (0~2 points) and summed to yield RGS-TUG score, ranging from 0 to 4 points, with higher points indicating better physical function. Cox proportional hazards regression was used to analyze association of RGS-TUG score with incident T2DM. Results: 3,892 participants without T2DM were followed up for an average of 3.6 years with 240 developing T2DM. After adjustment, those with the lowest RGS-TUG score, versus the highest, had higher fasting glucose, two-hour post-load glucose and glycosylated hemoglobin A1c, with β (95% confidence interval (CI)) being 0.21 (0.08, 0.33), 1.06 (0.69, 1.43) and 0.16 (0.06, 0.27), respectively. In participants with BMI of ≥25 kg/m2, those with the lowest RGS-TUG score showed a higher risk of T2DM (adjusted hazard ratio 3.01, 95% CI 1.04–8.69). No association was found for BMI of 18.5~<25 kg/m2 (P for interaction < 0.05). Conclusions: This is the first study showing lower RGS-TUG score was associated with increased glycemia and incident T2DM in older people with overweight/obesity. The underlying mechanisms warrant further investigation.-
dc.languageeng-
dc.publisherImpact Journals LLC. The Journal's web site is located at http://www.impactaging.com-
dc.relation.ispartofAging-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectRGS-TUG score-
dc.subjectrelative grip strength-
dc.subjecttimed up and go test-
dc.subjectincident type 2 diabetes mellitus-
dc.titleAssociation of a composite score of relative grip strength and timed up and go test with incident type 2 diabetes mellitus: Guangzhou Biobank Cohort Study-
dc.typeArticle-
dc.identifier.emailJiang, CQ: cqjiang@hkucc.hku.hk-
dc.identifier.emailZhang, WS: zhangws9@hku.hk-
dc.identifier.emailCheng, KK: chengkk@hkucc.hku.hk-
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hk-
dc.identifier.emailXu, L: linxu@hku.hk-
dc.identifier.authorityLam, TH=rp00326-
dc.identifier.authorityXu, L=rp02030-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.18632/aging.203285-
dc.identifier.pmid34273143-
dc.identifier.pmcidPMC8351683-
dc.identifier.scopuseid_2-s2.0-85112329788-
dc.identifier.hkuros324721-
dc.identifier.volume13-
dc.identifier.issue14-
dc.identifier.spage18376-
dc.identifier.epage18391-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats