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- Publisher Website: 10.3390/MI11040385
- Scopus: eid_2-s2.0-85083306881
- PMID: 32260509
- WOS: WOS:000531830000047
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Article: Design and fabrication of optical flow cell for multiplex detection of β-lactamase in microchannels
Title | Design and fabrication of optical flow cell for multiplex detection of β-lactamase in microchannels |
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Authors | |
Keywords | Linear actuators Point-of-care (POC) diagnostics Analytical chemistry Beta-lactamase Optical detections Microfluidics Absorbance Lab-on-a-chip Antimicrobial resistance (AMR) |
Issue Date | 2020 |
Citation | Micromachines, 2020, v. 11, n. 4, article no. 385 How to Cite? |
Abstract | Miniaturized quantitative assays o_er multiplexing capability in a microfluidic device for high-throughput applications such as antimicrobial resistance (AMR) studies. The detection of these multiple microchannels in a single microfluidic device becomes crucial for point-of-care (POC) testing and clinical diagnostics. This paper showcases an optical flow cell for detection of parallel microchannels in a microfluidic chip. The flow cell operates by measuring the light intensity from the microchannels based on Beer-Lambert law in a linearly moving chip. While this platform could be tailored for a wide variety of applications, here we show the design, fabrication and working principle of the device. β-lactamase, an indicator of bacterial resistance to β-lactam antibiotics, especially in milk, is shown as an example. The flow cell has a small footprint and uses low-powered, low-cost components, which makes it ideally suited for use in portable devices that require multiple sample detection in a single chip. |
Persistent Identifier | http://hdl.handle.net/10722/303665 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Hassan, Sammer ul | - |
dc.contributor.author | Zhang, Xunli | - |
dc.date.accessioned | 2021-09-15T08:25:46Z | - |
dc.date.available | 2021-09-15T08:25:46Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Micromachines, 2020, v. 11, n. 4, article no. 385 | - |
dc.identifier.uri | http://hdl.handle.net/10722/303665 | - |
dc.description.abstract | Miniaturized quantitative assays o_er multiplexing capability in a microfluidic device for high-throughput applications such as antimicrobial resistance (AMR) studies. The detection of these multiple microchannels in a single microfluidic device becomes crucial for point-of-care (POC) testing and clinical diagnostics. This paper showcases an optical flow cell for detection of parallel microchannels in a microfluidic chip. The flow cell operates by measuring the light intensity from the microchannels based on Beer-Lambert law in a linearly moving chip. While this platform could be tailored for a wide variety of applications, here we show the design, fabrication and working principle of the device. β-lactamase, an indicator of bacterial resistance to β-lactam antibiotics, especially in milk, is shown as an example. The flow cell has a small footprint and uses low-powered, low-cost components, which makes it ideally suited for use in portable devices that require multiple sample detection in a single chip. | - |
dc.language | eng | - |
dc.relation.ispartof | Micromachines | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Linear actuators | - |
dc.subject | Point-of-care (POC) diagnostics | - |
dc.subject | Analytical chemistry | - |
dc.subject | Beta-lactamase | - |
dc.subject | Optical detections | - |
dc.subject | Microfluidics | - |
dc.subject | Absorbance | - |
dc.subject | Lab-on-a-chip | - |
dc.subject | Antimicrobial resistance (AMR) | - |
dc.title | Design and fabrication of optical flow cell for multiplex detection of β-lactamase in microchannels | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/MI11040385 | - |
dc.identifier.pmid | 32260509 | - |
dc.identifier.pmcid | PMC7230666 | - |
dc.identifier.scopus | eid_2-s2.0-85083306881 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | article no. 385 | - |
dc.identifier.epage | article no. 385 | - |
dc.identifier.eissn | 2072-666X | - |
dc.identifier.isi | WOS:000531830000047 | - |