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Article: The Multiple Roles of B Cells in the Pathogenesis of Sjögren’s Syndrome

TitleThe Multiple Roles of B Cells in the Pathogenesis of Sjögren’s Syndrome
Authors
Keywordsprimary Sjögren’s syndrome
B cells
pathogenesis
treatment
regulatory functions
Issue Date2021
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology
Citation
Frontiers in Immunology, 2021, v. 12, p. article no. 684999 How to Cite?
AbstractPrimary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic infiltration and tissue destruction of exocrine glands such as salivary glands. Although the formation of ectopic lymphoid tissue in exocrine glands and overproduction of autoantibodies by autoreactive B cells highlight the critical involvement of B cells in disease development, the precise roles of various B cell subsets in pSS pathogenesis remain partially understood. Current studies have identified several novel B cell subsets with multiple functions in pSS, among which autoreactive age-associated B cells, and plasma cells with augmented autoantibody production contribute to the disease progression. In addition, tissue-resident Fc Receptor-Like 4 (FcRL4)+ B cell subset with enhanced pro-inflammatory cytokine production serves as a key driver in pSS patients with mucosa-associated lymphoid tissue (MALT)-lymphomas. Recently, regulatory B (Breg) cells with impaired immunosuppressive functions are found negatively correlated with T follicular helper (Tfh) cells in pSS patients. Further studies have revealed a pivotal role of Breg cells in constraining Tfh response in autoimmune pathogenesis. This review provides an overview of recent advances in the identification of pathogenic B cell subsets and Breg cells, as well as new development of B-cell targeted therapies in pSS patients.
Persistent Identifierhttp://hdl.handle.net/10722/305081
ISSN
2020 Impact Factor: 7.561
2020 SCImago Journal Rankings: 2.646
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorDu, W-
dc.contributor.authorHan, M-
dc.contributor.authorZhu, X-
dc.contributor.authorXiao, F-
dc.contributor.authorHuang, E-
dc.contributor.authorChe, N-
dc.contributor.authorTang, X-
dc.contributor.authorZou, H-
dc.contributor.authorJiang, Q-
dc.contributor.authorLu, L-
dc.date.accessioned2021-10-05T02:39:28Z-
dc.date.available2021-10-05T02:39:28Z-
dc.date.issued2021-
dc.identifier.citationFrontiers in Immunology, 2021, v. 12, p. article no. 684999-
dc.identifier.issn1664-3224-
dc.identifier.urihttp://hdl.handle.net/10722/305081-
dc.description.abstractPrimary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic infiltration and tissue destruction of exocrine glands such as salivary glands. Although the formation of ectopic lymphoid tissue in exocrine glands and overproduction of autoantibodies by autoreactive B cells highlight the critical involvement of B cells in disease development, the precise roles of various B cell subsets in pSS pathogenesis remain partially understood. Current studies have identified several novel B cell subsets with multiple functions in pSS, among which autoreactive age-associated B cells, and plasma cells with augmented autoantibody production contribute to the disease progression. In addition, tissue-resident Fc Receptor-Like 4 (FcRL4)+ B cell subset with enhanced pro-inflammatory cytokine production serves as a key driver in pSS patients with mucosa-associated lymphoid tissue (MALT)-lymphomas. Recently, regulatory B (Breg) cells with impaired immunosuppressive functions are found negatively correlated with T follicular helper (Tfh) cells in pSS patients. Further studies have revealed a pivotal role of Breg cells in constraining Tfh response in autoimmune pathogenesis. This review provides an overview of recent advances in the identification of pathogenic B cell subsets and Breg cells, as well as new development of B-cell targeted therapies in pSS patients.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology-
dc.relation.ispartofFrontiers in Immunology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectprimary Sjögren’s syndrome-
dc.subjectB cells-
dc.subjectpathogenesis-
dc.subjecttreatment-
dc.subjectregulatory functions-
dc.titleThe Multiple Roles of B Cells in the Pathogenesis of Sjögren’s Syndrome-
dc.typeArticle-
dc.identifier.emailDu, W: dwh1991@hku.hk-
dc.identifier.emailXiao, F: xiaof@hku.hk-
dc.identifier.emailHuang, E: heyhk49@hku.hk-
dc.identifier.emailLu, L: liweilu@hku.hk-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fimmu.2021.684999-
dc.identifier.pmid34168653-
dc.identifier.pmcidPMC8217880-
dc.identifier.scopuseid_2-s2.0-85108316671-
dc.identifier.hkuros326241-
dc.identifier.volume12-
dc.identifier.spagearticle no. 684999-
dc.identifier.epagearticle no. 684999-
dc.publisher.placeSwitzerland-

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