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Article: β-Difluoroalkylamine as a Motif for Singlet Oxygen-Mediated Proximity Labeling in Living Cells

Titleβ-Difluoroalkylamine as a Motif for Singlet Oxygen-Mediated Proximity Labeling in Living Cells
Authors
LIANG, JJIA, HLI, LLi, XLi, Y
Issue Date2021
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html
Citation
Organic Letters, 2021, v. 23 n. 12, p. 4640-4644 How to Cite?
DOI: http://dx.doi.org/10.1021/acs.orglett.1c01377
AbstractWe designed β-difluoroalkylamine to capture RNAs and proteins with high tempospatial resolution via proximity labeling mediated by photoinduced singlet oxygen. The appended azide group allows for RNA biotinylation and downstream analysis through both SPAAC and CuAAC. In particular, the β-difluoroalkylazide motif enjoys an enhanced CuAAC reaction rate, thus preserving good RNA integrity.
Persistent Identifierhttp://hdl.handle.net/10722/305288
ISSN
1523-7060
2021 Impact Factor: 6.072
2020 SCImago Journal Rankings: 1.940
ISI Accession Number ID
WOS:000664333200027

 

DC FieldValueLanguage
dc.contributor.authorLIANG, J-
dc.contributor.authorJIA, H-
dc.contributor.authorLI, L-
dc.contributor.authorLi, X-
dc.contributor.authorLi, Y-
dc.date.accessioned2021-10-20T10:07:18Z-
dc.date.available2021-10-20T10:07:18Z-
dc.date.issued2021-
dc.identifier.citationOrganic Letters, 2021, v. 23 n. 12, p. 4640-4644-
dc.identifier.issn1523-7060-
dc.identifier.urihttp://hdl.handle.net/10722/305288-
dc.description.abstractWe designed β-difluoroalkylamine to capture RNAs and proteins with high tempospatial resolution via proximity labeling mediated by photoinduced singlet oxygen. The appended azide group allows for RNA biotinylation and downstream analysis through both SPAAC and CuAAC. In particular, the β-difluoroalkylazide motif enjoys an enhanced CuAAC reaction rate, thus preserving good RNA integrity.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html-
dc.relation.ispartofOrganic Letters-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.titleβ-Difluoroalkylamine as a Motif for Singlet Oxygen-Mediated Proximity Labeling in Living Cells-
dc.typeArticle-
dc.identifier.emailLi, Y: yingli0e@hku.hk-
dc.identifier.authorityLi, Y=rp02548-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.orglett.1c01377-
dc.identifier.pmid34076445-
dc.identifier.scopuseid_2-s2.0-85108552859-
dc.identifier.hkuros328373-
dc.identifier.volume23-
dc.identifier.issue12-
dc.identifier.spage4640-
dc.identifier.epage4644-
dc.identifier.isiWOS:000664333200027-
dc.publisher.placeUnited States-

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