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Article: Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer

TitleProteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer
Authors
McGrail, Daniel J.Garnett, JeannineYin, JunDai, HuiShih, David J.H.Lam, Truong Nguyen AnhLi, YangSun, ChaoyangLi, YongshengSchmandt, RosemarieWu, Ji YuanHu, LimeiLiang, YulongPeng, GuangJonasch, EricMenter, DavidYates, Melinda S.Kopetz, ScottLu, Karen H.Broaddus, RussellMills, Gordon B.Sahni, NidhiLin, Shiaw Yih
Keywordscolorectal cancer (COAD)
endometrial cancer (UCEC)
immunotherapy
microsatellite instability (MSI)
mismatch repair (MMR)
neddylation
protein degredation
protein homeostasis
Issue Date2020
Citation
Cancer Cell, 2020, v. 37, n. 3, p. 371-386.e12 How to Cite?
DOI: http://dx.doi.org/10.1016/j.ccell.2020.01.011
AbstractMcGrail et al. find that the abundance of destabilizing mutations in microsatellite unstable (MSI) tumors causes proteome instability and accumulation of misfolded proteins. To compensate, MSI tumors rely on a Nedd8-mediated pathway to clear misfolded aggregates, which can be therapeutically targeted by MLN4924.
Persistent Identifierhttp://hdl.handle.net/10722/313985
ISSN
1535-6108
2021 Impact Factor: 38.585
2020 SCImago Journal Rankings: 13.035
PubMed Central ID
PMC7337255
ISI Accession Number ID
WOS:000520110400011

 

DC FieldValueLanguage
dc.contributor.authorMcGrail, Daniel J.-
dc.contributor.authorGarnett, Jeannine-
dc.contributor.authorYin, Jun-
dc.contributor.authorDai, Hui-
dc.contributor.authorShih, David J.H.-
dc.contributor.authorLam, Truong Nguyen Anh-
dc.contributor.authorLi, Yang-
dc.contributor.authorSun, Chaoyang-
dc.contributor.authorLi, Yongsheng-
dc.contributor.authorSchmandt, Rosemarie-
dc.contributor.authorWu, Ji Yuan-
dc.contributor.authorHu, Limei-
dc.contributor.authorLiang, Yulong-
dc.contributor.authorPeng, Guang-
dc.contributor.authorJonasch, Eric-
dc.contributor.authorMenter, David-
dc.contributor.authorYates, Melinda S.-
dc.contributor.authorKopetz, Scott-
dc.contributor.authorLu, Karen H.-
dc.contributor.authorBroaddus, Russell-
dc.contributor.authorMills, Gordon B.-
dc.contributor.authorSahni, Nidhi-
dc.contributor.authorLin, Shiaw Yih-
dc.date.accessioned2022-07-06T11:28:43Z-
dc.date.available2022-07-06T11:28:43Z-
dc.date.issued2020-
dc.identifier.citationCancer Cell, 2020, v. 37, n. 3, p. 371-386.e12-
dc.identifier.issn1535-6108-
dc.identifier.urihttp://hdl.handle.net/10722/313985-
dc.description.abstractMcGrail et al. find that the abundance of destabilizing mutations in microsatellite unstable (MSI) tumors causes proteome instability and accumulation of misfolded proteins. To compensate, MSI tumors rely on a Nedd8-mediated pathway to clear misfolded aggregates, which can be therapeutically targeted by MLN4924.-
dc.languageeng-
dc.relation.ispartofCancer Cell-
dc.subjectcolorectal cancer (COAD)-
dc.subjectendometrial cancer (UCEC)-
dc.subjectimmunotherapy-
dc.subjectmicrosatellite instability (MSI)-
dc.subjectmismatch repair (MMR)-
dc.subjectneddylation-
dc.subjectprotein degredation-
dc.subjectprotein homeostasis-
dc.titleProteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ccell.2020.01.011-
dc.identifier.pmid32109374-
dc.identifier.pmcidPMC7337255-
dc.identifier.scopuseid_2-s2.0-85081226123-
dc.identifier.volume37-
dc.identifier.issue3-
dc.identifier.spage371-
dc.identifier.epage386.e12-
dc.identifier.eissn1878-3686-
dc.identifier.isiWOS:000520110400011-

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