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- Publisher Website: 10.1038/s41598-017-01683-7
- Scopus: eid_2-s2.0-85019553674
- PMID: 28512290
- WOS: WOS:000401406700043
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Article: Evolution of Drug-resistant Acinetobacter baumannii after DCD Renal Transplantation
Title | Evolution of Drug-resistant Acinetobacter baumannii after DCD Renal Transplantation |
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Authors | |
Issue Date | 2017 |
Citation | Scientific Reports, 2017, v. 7, n. 1, article no. 1968 How to Cite? |
Abstract | Infection after renal transplantation remains a major cause of morbidity and death, especially infection from the extensively drug-resistant bacteria, A. baumannii. A total of fourteen A. baumannii isolates were isolated from the donors' preserved fluid from DCD (donation after cardiac death) renal transplantation and four isolates in the recipients' draining liquid at the Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, from March 2013 to November 2014. An outbreak of A. baumannii emerging after DCD renal transplantation was tracked to understand the transmission of the pathogen. PFGE displayed similar DNA patterns between isolates from the same hospital. Antimicrobial susceptibility tests against thirteen antimicrobial agents were determined using the K-B diffusion method and eTest. Whole-genome sequencing was applied to investigate the genetic relationship of the isolates. With the clinical data and research results, we concluded that the A. baumannii isolates 3R1 and 3R2 was probably transmitted from the donor who acquired the bacteria during his stay in the ICU, while isolate 4R1 was transmitted from 3R1 and 3R2 via medical manipulation. This study demonstrated the value of integration of clinical profiles with molecular methods in outbreak investigation and their importance in controlling infection and preventing serious complications after DCD transplantation. |
Persistent Identifier | http://hdl.handle.net/10722/324492 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Jiang, Hong | - |
dc.contributor.author | Cao, Luxi | - |
dc.contributor.author | Qu, Lihui | - |
dc.contributor.author | Qu, Tingting | - |
dc.contributor.author | Liu, Guangjun | - |
dc.contributor.author | Wang, Rending | - |
dc.contributor.author | Li, Bingjue | - |
dc.contributor.author | Wang, Yuchen | - |
dc.contributor.author | Ying, Chaoqun | - |
dc.contributor.author | Chen, Miao | - |
dc.contributor.author | Lu, Yingying | - |
dc.contributor.author | Feng, Shi | - |
dc.contributor.author | Xiao, Yonghong | - |
dc.contributor.author | Wang, Junwen | - |
dc.contributor.author | Wu, Jianyong | - |
dc.contributor.author | Chen, Jianghua | - |
dc.date.accessioned | 2023-02-03T07:03:26Z | - |
dc.date.available | 2023-02-03T07:03:26Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Scientific Reports, 2017, v. 7, n. 1, article no. 1968 | - |
dc.identifier.uri | http://hdl.handle.net/10722/324492 | - |
dc.description.abstract | Infection after renal transplantation remains a major cause of morbidity and death, especially infection from the extensively drug-resistant bacteria, A. baumannii. A total of fourteen A. baumannii isolates were isolated from the donors' preserved fluid from DCD (donation after cardiac death) renal transplantation and four isolates in the recipients' draining liquid at the Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, from March 2013 to November 2014. An outbreak of A. baumannii emerging after DCD renal transplantation was tracked to understand the transmission of the pathogen. PFGE displayed similar DNA patterns between isolates from the same hospital. Antimicrobial susceptibility tests against thirteen antimicrobial agents were determined using the K-B diffusion method and eTest. Whole-genome sequencing was applied to investigate the genetic relationship of the isolates. With the clinical data and research results, we concluded that the A. baumannii isolates 3R1 and 3R2 was probably transmitted from the donor who acquired the bacteria during his stay in the ICU, while isolate 4R1 was transmitted from 3R1 and 3R2 via medical manipulation. This study demonstrated the value of integration of clinical profiles with molecular methods in outbreak investigation and their importance in controlling infection and preventing serious complications after DCD transplantation. | - |
dc.language | eng | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Evolution of Drug-resistant Acinetobacter baumannii after DCD Renal Transplantation | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41598-017-01683-7 | - |
dc.identifier.pmid | 28512290 | - |
dc.identifier.pmcid | PMC5434021 | - |
dc.identifier.scopus | eid_2-s2.0-85019553674 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 1968 | - |
dc.identifier.epage | article no. 1968 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.isi | WOS:000401406700043 | - |