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Article: Antibiotics-impregnated ventricular catheter versus systemic antibiotics for prevention of nosocomial CSF and non-CSF infections: A prospective randomised clinical trial

TitleAntibiotics-impregnated ventricular catheter versus systemic antibiotics for prevention of nosocomial CSF and non-CSF infections: A prospective randomised clinical trial
Authors
Issue Date2010
Citation
Journal of Neurology, Neurosurgery and Psychiatry, 2010, v. 81, n. 10, p. 1064-1067 How to Cite?
AbstractBackground: In recent years, cranial ventricular catheters impregnated with antimicrobial agents have become available. Theoretically, they provide antibiotic prophylaxis locally without the associated complications of opportunistic nosocomial infections. This study aims to compare antibiotic impregnated catheters with conventional catheters coupled with systemic antibiotics. Methods: Patients undergoing emergency neurosurgical operations were recruited. Patients were randomly assigned to antibiotic impregnated catheters (Bactiseal, Codman, Johnson & Johnson, Raynham, MA, USA) or conventional catheters coupled with systemic antibiotics. Results: 184 neurosurgical patients were enrolled between April 2004 and December 2008. Mean duration of ventricular catheter was 10 days for both groups. The proportion of patients with nosocomial infection was not significantly different: 57% (51/90) in the Bactiseal group and 51% (48/94) in the conventional group (OR 1.3, 0.7 to 2.2). There were also no differences in secondary outcome measures (CSF infection, intensive care unit stay, acute hospital stay and functional outcome) between the two groups. Conclusions: Antibiotic impregnated catheters are as effective as systemic antibiotics in the prevention of CSF infection and their corresponding nosocomial infection rates are not significantly different.
Persistent Identifierhttp://hdl.handle.net/10722/325211
ISSN
2023 Impact Factor: 8.7
2023 SCImago Journal Rankings: 2.959
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, George K.C.-
dc.contributor.authorIp, Margaret-
dc.contributor.authorPoon, Wai S.-
dc.contributor.authorMak, Christopher W.K.-
dc.contributor.authorNg, Rebecca Y.T.-
dc.date.accessioned2023-02-27T07:30:38Z-
dc.date.available2023-02-27T07:30:38Z-
dc.date.issued2010-
dc.identifier.citationJournal of Neurology, Neurosurgery and Psychiatry, 2010, v. 81, n. 10, p. 1064-1067-
dc.identifier.issn0022-3050-
dc.identifier.urihttp://hdl.handle.net/10722/325211-
dc.description.abstractBackground: In recent years, cranial ventricular catheters impregnated with antimicrobial agents have become available. Theoretically, they provide antibiotic prophylaxis locally without the associated complications of opportunistic nosocomial infections. This study aims to compare antibiotic impregnated catheters with conventional catheters coupled with systemic antibiotics. Methods: Patients undergoing emergency neurosurgical operations were recruited. Patients were randomly assigned to antibiotic impregnated catheters (Bactiseal, Codman, Johnson & Johnson, Raynham, MA, USA) or conventional catheters coupled with systemic antibiotics. Results: 184 neurosurgical patients were enrolled between April 2004 and December 2008. Mean duration of ventricular catheter was 10 days for both groups. The proportion of patients with nosocomial infection was not significantly different: 57% (51/90) in the Bactiseal group and 51% (48/94) in the conventional group (OR 1.3, 0.7 to 2.2). There were also no differences in secondary outcome measures (CSF infection, intensive care unit stay, acute hospital stay and functional outcome) between the two groups. Conclusions: Antibiotic impregnated catheters are as effective as systemic antibiotics in the prevention of CSF infection and their corresponding nosocomial infection rates are not significantly different.-
dc.languageeng-
dc.relation.ispartofJournal of Neurology, Neurosurgery and Psychiatry-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleAntibiotics-impregnated ventricular catheter versus systemic antibiotics for prevention of nosocomial CSF and non-CSF infections: A prospective randomised clinical trial-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1136/jnnp.2009.198523-
dc.identifier.pmid20466698-
dc.identifier.scopuseid_2-s2.0-77958133844-
dc.identifier.volume81-
dc.identifier.issue10-
dc.identifier.spage1064-
dc.identifier.epage1067-
dc.identifier.eissn1468-330X-
dc.identifier.isiWOS:000282176900045-

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