File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Pseudoprogression of malignant glioma in Chinese patients receiving concomitant chemoradiotherapy

TitlePseudoprogression of malignant glioma in Chinese patients receiving concomitant chemoradiotherapy
Authors
KeywordsAlkylating
Antineoplastic agents
Biological markers
Brain neoplasms
Glioblastoma
O(6)-methylguanine-dna methyltransferase
Issue Date2012
Citation
Hong Kong Medical Journal, 2012, v. 18, n. 3, p. 221-225 How to Cite?
AbstractObjectives To investigate the frequency of pseudoprogression of glioblastoma in Chinese patients receiving concomitant chemoradiotherapy and investigate its association with pseudoprogression and tumour molecular marker O6- methylguanine-DNA methyltransferase promoter methylation status. Design Case series with internal comparisons. Setting University teaching hospital, Hong Kong. Patients Patients with glioblastoma treated with concomitant chemoradiotherapy during April 2005 to June 2010 were reviewed. Magnetic resonance imaging brain scans, preand post-concomitant chemoradiotherapy and 3-monthly thereafter were reviewed by an independent neuroradiologist according to Macdonald's criteria. Relevant patient information (clinical condition, performance score, development of new neurological deficits, use of steroids, and survival) was retrieved. For each patient, O6-methylguanine-DNA methyltransferase methylation status was investigated with genomic DNA from formalin-fixed or paraffin-embedded sections of tumour tissues by methylation-specific polymerase chain reaction. Results During the study period, 28 primary glioblastoma patients underwent concomitant chemoradiotherapy. The mean age of the patients was 48 (range, 16-71) years. Thirteen patients (13/28, 46%) developed early radiological progression of the tumour after completion of concomitant chemoradiotherapy, of whom five (39%) were subsequently found to have had pseudoprogression. Patients with pseudoprogression showed a trend towards longer survival (22 months in pseudoprogression vs 17 months in all others vs 11 months in those with genuine progression). Among the 27 patients tested for O6- methylguanine-DNA methyltransferase promoter status, 12 (44%) were methylated. Two (2/12, 17%) in the methylated group had pseudoprogression, while three (3/15, 20%) in the unmethylated group had pseudoprogression. Conclusions Nearly half of all patients (46%) developed early radiological progression (within 3 months of completing concomitant chemoradiotherapy). Moreover, about one in three of such patients had pseudoprogression. Pseudoprogression is an important clinical condition to be aware of to prevent premature termination of an effective treatment.
Persistent Identifierhttp://hdl.handle.net/10722/325237
ISSN
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 0.261
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, Danny T.M.-
dc.contributor.authorNg, Rebecca Y.T.-
dc.contributor.authorSiu, Deyond Y.W.-
dc.contributor.authorTang, Peggy-
dc.contributor.authorKam, Michael K.M.-
dc.contributor.authorMa, Brigette B.Y.-
dc.contributor.authorWong, George K.C.-
dc.contributor.authorNg, Stephanie C.P.-
dc.contributor.authorPang, Jesse C.S.-
dc.contributor.authorLau, Claire K.Y.-
dc.contributor.authorZhu, X. L.-
dc.contributor.authorNg, H. K.-
dc.contributor.authorPoon, W. S.-
dc.date.accessioned2023-02-27T07:30:52Z-
dc.date.available2023-02-27T07:30:52Z-
dc.date.issued2012-
dc.identifier.citationHong Kong Medical Journal, 2012, v. 18, n. 3, p. 221-225-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/325237-
dc.description.abstractObjectives To investigate the frequency of pseudoprogression of glioblastoma in Chinese patients receiving concomitant chemoradiotherapy and investigate its association with pseudoprogression and tumour molecular marker O6- methylguanine-DNA methyltransferase promoter methylation status. Design Case series with internal comparisons. Setting University teaching hospital, Hong Kong. Patients Patients with glioblastoma treated with concomitant chemoradiotherapy during April 2005 to June 2010 were reviewed. Magnetic resonance imaging brain scans, preand post-concomitant chemoradiotherapy and 3-monthly thereafter were reviewed by an independent neuroradiologist according to Macdonald's criteria. Relevant patient information (clinical condition, performance score, development of new neurological deficits, use of steroids, and survival) was retrieved. For each patient, O6-methylguanine-DNA methyltransferase methylation status was investigated with genomic DNA from formalin-fixed or paraffin-embedded sections of tumour tissues by methylation-specific polymerase chain reaction. Results During the study period, 28 primary glioblastoma patients underwent concomitant chemoradiotherapy. The mean age of the patients was 48 (range, 16-71) years. Thirteen patients (13/28, 46%) developed early radiological progression of the tumour after completion of concomitant chemoradiotherapy, of whom five (39%) were subsequently found to have had pseudoprogression. Patients with pseudoprogression showed a trend towards longer survival (22 months in pseudoprogression vs 17 months in all others vs 11 months in those with genuine progression). Among the 27 patients tested for O6- methylguanine-DNA methyltransferase promoter status, 12 (44%) were methylated. Two (2/12, 17%) in the methylated group had pseudoprogression, while three (3/15, 20%) in the unmethylated group had pseudoprogression. Conclusions Nearly half of all patients (46%) developed early radiological progression (within 3 months of completing concomitant chemoradiotherapy). Moreover, about one in three of such patients had pseudoprogression. Pseudoprogression is an important clinical condition to be aware of to prevent premature termination of an effective treatment.-
dc.languageeng-
dc.relation.ispartofHong Kong Medical Journal-
dc.subjectAlkylating-
dc.subjectAntineoplastic agents-
dc.subjectBiological markers-
dc.subjectBrain neoplasms-
dc.subjectGlioblastoma-
dc.subjectO(6)-methylguanine-dna methyltransferase-
dc.titlePseudoprogression of malignant glioma in Chinese patients receiving concomitant chemoradiotherapy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid22665686-
dc.identifier.scopuseid_2-s2.0-84862549728-
dc.identifier.volume18-
dc.identifier.issue3-
dc.identifier.spage221-
dc.identifier.epage225-
dc.identifier.isiWOS:000304849200008-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats