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- Publisher Website: 10.1016/j.bbrc.2012.10.120
- Scopus: eid_2-s2.0-84870678232
- PMID: 23142225
- WOS: WOS:000312514200008
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Article: Elevated chemokine CC-motif receptor-like 2 (CCRL2) promotes cell migration and invasion in glioblastoma
Title | Elevated chemokine CC-motif receptor-like 2 (CCRL2) promotes cell migration and invasion in glioblastoma |
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Authors | |
Keywords | CCRL2 Glioblastoma Glioma dissemination Tumor invasion Tumor migration |
Issue Date | 2012 |
Citation | Biochemical and Biophysical Research Communications, 2012, v. 429, n. 3-4, p. 168-172 How to Cite? |
Abstract | Chemokine CC-motif receptor-like 2 (CCRL2) is a 7-transmembrane G protein-coupled receptor which plays a key role in lung dendritic cell trafficking to peripheral lymph nodes. The function and expression of CCRL2 in cancer is not understood at present. Here we report that CCRL2 expression level is elevated in human glioma patient samples and cell lines. The magnitude of increase is positively associated with increasing tumor grade, with the highest level observed in grade IV glioblastoma. By gain-of-function and loss-of-function studies, we further showed that CCRL2 did not regulate the growth of human glioblatoma U87 and U373 cells. Importantly, we demonstrated that over-expression of CCRL2 significantly enhanced the migration rate and invasiveness of the glioblastoma cells. Taken together, these results suggest for the first time that elevated CCRL2 in glioma promotes cell migration and invasion. The potential roles of CCRL2 as a novel therapeutic target and biomarker warrant further investigations. © 2012 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/325253 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.770 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yin, Fengqiong | - |
dc.contributor.author | Xu, Zhenhua | - |
dc.contributor.author | Wang, Zifeng | - |
dc.contributor.author | Yao, Hong | - |
dc.contributor.author | Shen, Zan | - |
dc.contributor.author | Yu, Fang | - |
dc.contributor.author | Tang, Yiping | - |
dc.contributor.author | Fu, Dengli | - |
dc.contributor.author | Lin, Sheng | - |
dc.contributor.author | Lu, Gang | - |
dc.contributor.author | Kung, Hsiang Fu | - |
dc.contributor.author | Poon, Wai Sang | - |
dc.contributor.author | Huang, Yunchao | - |
dc.contributor.author | Lin, Marie Chia Mi | - |
dc.date.accessioned | 2023-02-27T07:30:59Z | - |
dc.date.available | 2023-02-27T07:30:59Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, 2012, v. 429, n. 3-4, p. 168-172 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10722/325253 | - |
dc.description.abstract | Chemokine CC-motif receptor-like 2 (CCRL2) is a 7-transmembrane G protein-coupled receptor which plays a key role in lung dendritic cell trafficking to peripheral lymph nodes. The function and expression of CCRL2 in cancer is not understood at present. Here we report that CCRL2 expression level is elevated in human glioma patient samples and cell lines. The magnitude of increase is positively associated with increasing tumor grade, with the highest level observed in grade IV glioblastoma. By gain-of-function and loss-of-function studies, we further showed that CCRL2 did not regulate the growth of human glioblatoma U87 and U373 cells. Importantly, we demonstrated that over-expression of CCRL2 significantly enhanced the migration rate and invasiveness of the glioblastoma cells. Taken together, these results suggest for the first time that elevated CCRL2 in glioma promotes cell migration and invasion. The potential roles of CCRL2 as a novel therapeutic target and biomarker warrant further investigations. © 2012 Elsevier Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | - |
dc.subject | CCRL2 | - |
dc.subject | Glioblastoma | - |
dc.subject | Glioma dissemination | - |
dc.subject | Tumor invasion | - |
dc.subject | Tumor migration | - |
dc.title | Elevated chemokine CC-motif receptor-like 2 (CCRL2) promotes cell migration and invasion in glioblastoma | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.bbrc.2012.10.120 | - |
dc.identifier.pmid | 23142225 | - |
dc.identifier.scopus | eid_2-s2.0-84870678232 | - |
dc.identifier.volume | 429 | - |
dc.identifier.issue | 3-4 | - |
dc.identifier.spage | 168 | - |
dc.identifier.epage | 172 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.isi | WOS:000312514200008 | - |