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- Publisher Website: 10.1016/j.canlet.2012.12.006
- Scopus: eid_2-s2.0-84873523265
- PMID: 23246373
- WOS: WOS:000315610100001
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Article: Transcriptional and epigenetic regulation of human microRNAs
Title | Transcriptional and epigenetic regulation of human microRNAs |
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Authors | |
Keywords | Cancer Epigenetic regulation MiRNA Transcription machinery Transcriptional regulation |
Issue Date | 2013 |
Citation | Cancer Letters, 2013, v. 331, n. 1, p. 1-10 How to Cite? |
Abstract | MicroRNAs (miRNAs) are members of non-coding RNAs. They are involved in diverse biological functions. MiRNAs are precisely regulated in a tissue- and developmental-specific manner, but dysregulated in many human diseases, in particular cancers. Transcriptional regulation, post-transcriptional regulation, as well as genetic alterations, are the three major mechanisms controlling the spatial and temporal expression of miRNAs. Emerging evidence now indicates that transcriptional and epigenetic regulations play major roles in miRNA expression. This review summarizes the current knowledge and discusses the future challenges. © 2012 Elsevier Ireland Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/325258 |
ISSN | 2023 Impact Factor: 9.1 2023 SCImago Journal Rankings: 2.595 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, Zifeng | - |
dc.contributor.author | Yao, Hong | - |
dc.contributor.author | Lin, Sheng | - |
dc.contributor.author | Zhu, Xiao | - |
dc.contributor.author | Shen, Zan | - |
dc.contributor.author | Lu, Gang | - |
dc.contributor.author | Poon, Wai Sang | - |
dc.contributor.author | Xie, Dan | - |
dc.contributor.author | Lin, Marie Chia Mi | - |
dc.contributor.author | Kung, Hsiang Fu | - |
dc.date.accessioned | 2023-02-27T07:31:01Z | - |
dc.date.available | 2023-02-27T07:31:01Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Cancer Letters, 2013, v. 331, n. 1, p. 1-10 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://hdl.handle.net/10722/325258 | - |
dc.description.abstract | MicroRNAs (miRNAs) are members of non-coding RNAs. They are involved in diverse biological functions. MiRNAs are precisely regulated in a tissue- and developmental-specific manner, but dysregulated in many human diseases, in particular cancers. Transcriptional regulation, post-transcriptional regulation, as well as genetic alterations, are the three major mechanisms controlling the spatial and temporal expression of miRNAs. Emerging evidence now indicates that transcriptional and epigenetic regulations play major roles in miRNA expression. This review summarizes the current knowledge and discusses the future challenges. © 2012 Elsevier Ireland Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Cancer Letters | - |
dc.subject | Cancer | - |
dc.subject | Epigenetic regulation | - |
dc.subject | MiRNA | - |
dc.subject | Transcription machinery | - |
dc.subject | Transcriptional regulation | - |
dc.title | Transcriptional and epigenetic regulation of human microRNAs | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.canlet.2012.12.006 | - |
dc.identifier.pmid | 23246373 | - |
dc.identifier.scopus | eid_2-s2.0-84873523265 | - |
dc.identifier.volume | 331 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 10 | - |
dc.identifier.eissn | 1872-7980 | - |
dc.identifier.isi | WOS:000315610100001 | - |