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- Publisher Website: 10.1016/j.stem.2023.05.012
- Scopus: eid_2-s2.0-85163852558
- PMID: 37315564
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Article: Organoid cultures for cancer modeling.
Title | Organoid cultures for cancer modeling. |
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Authors | |
Keywords | cancer organoids |
Issue Date | 6-Jul-2023 |
Publisher | Elsevier |
Citation | Cell Stem Cell, 2023, v. 30, n. 7, p. 917-937 How to Cite? |
Abstract | Organoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are important preclinical models for studying cancer and developing therapies. Here, we review primary tissue-derived and PSC-derived cancer organoid models and detail how they have the potential to inform personalized medical approaches in different organ contexts and contribute to the understanding of early carcinogenic steps, cancer genomes, and biology. We also compare the differences between ASC- and PSC-based cancer organoid systems, discuss their limitations, and highlight recent improvements to organoid culture approaches that have helped to make them an even better representation of human tumors. |
Persistent Identifier | http://hdl.handle.net/10722/331403 |
ISSN | 2021 Impact Factor: 25.269 2020 SCImago Journal Rankings: 8.860 |
DC Field | Value | Language |
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dc.contributor.author | Yan, HHN | - |
dc.contributor.author | Chan, AS | - |
dc.contributor.author | Lai, FP | - |
dc.contributor.author | Leung, SY | - |
dc.date.accessioned | 2023-09-21T06:55:24Z | - |
dc.date.available | 2023-09-21T06:55:24Z | - |
dc.date.issued | 2023-07-06 | - |
dc.identifier.citation | Cell Stem Cell, 2023, v. 30, n. 7, p. 917-937 | - |
dc.identifier.issn | 1934-5909 | - |
dc.identifier.uri | http://hdl.handle.net/10722/331403 | - |
dc.description.abstract | Organoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are important preclinical models for studying cancer and developing therapies. Here, we review primary tissue-derived and PSC-derived cancer organoid models and detail how they have the potential to inform personalized medical approaches in different organ contexts and contribute to the understanding of early carcinogenic steps, cancer genomes, and biology. We also compare the differences between ASC- and PSC-based cancer organoid systems, discuss their limitations, and highlight recent improvements to organoid culture approaches that have helped to make them an even better representation of human tumors. | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Cell Stem Cell | - |
dc.subject | cancer | - |
dc.subject | organoids | - |
dc.title | Organoid cultures for cancer modeling. | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.stem.2023.05.012 | - |
dc.identifier.pmid | 37315564 | - |
dc.identifier.scopus | eid_2-s2.0-85163852558 | - |
dc.identifier.volume | 30 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 917 | - |
dc.identifier.epage | 937 | - |
dc.identifier.eissn | 1875-9777 | - |
dc.identifier.issnl | 1875-9777 | - |