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Article: High Performance, Multiplexed Lung Cancer Biomarker Detection on a Plasmonic Gold Chip

TitleHigh Performance, Multiplexed Lung Cancer Biomarker Detection on a Plasmonic Gold Chip
Authors
Liu, BinLi, YalingWan, HaoWang, LinXu, WeiZhu, ShoujunLiang, YongyeZhang, BoLou, JiataoDai, HongjieQian, Kun
Keywordsdiagnostics
lung cancer
microarrays
plasmonic gold chips
serum biomarkers
Issue Date2016
Citation
Advanced Functional Materials, 2016, v. 26, n. 44, p. 7994-8002 How to Cite?
DOI: http://dx.doi.org/10.1002/adfm.201603547
AbstractDiagnosis of lung cancer is performed using a plasmonic gold (pGOLD) chip through multiplexed near-infrared (NIR) detection of carcino-embryonic antigen (CEA), Cyfra21-1, and neuron-specific enolase (NSE) in the serum samples of patients. With ≈50-fold enhancement of NIR fluorescence, multiplexed microarray analysis of CEA, Cyfra21-1, and NSE in 10 μL of human serum or whole blood samples on pGOLD chip leads to markedly improved limit-of-quantification, limit-of-detection, reproducibility, and higher diagnostic sensitivity and specificity compared to traditional biochips and Luminex technology currently in use in hospitals.
Persistent Identifierhttp://hdl.handle.net/10722/334445
ISSN
1616-301X
2021 Impact Factor: 19.924
2020 SCImago Journal Rankings: 6.069

 

DC FieldValueLanguage
dc.contributor.authorLiu, Bin-
dc.contributor.authorLi, Yaling-
dc.contributor.authorWan, Hao-
dc.contributor.authorWang, Lin-
dc.contributor.authorXu, Wei-
dc.contributor.authorZhu, Shoujun-
dc.contributor.authorLiang, Yongye-
dc.contributor.authorZhang, Bo-
dc.contributor.authorLou, Jiatao-
dc.contributor.authorDai, Hongjie-
dc.contributor.authorQian, Kun-
dc.date.accessioned2023-10-20T06:48:11Z-
dc.date.available2023-10-20T06:48:11Z-
dc.date.issued2016-
dc.identifier.citationAdvanced Functional Materials, 2016, v. 26, n. 44, p. 7994-8002-
dc.identifier.issn1616-301X-
dc.identifier.urihttp://hdl.handle.net/10722/334445-
dc.description.abstractDiagnosis of lung cancer is performed using a plasmonic gold (pGOLD) chip through multiplexed near-infrared (NIR) detection of carcino-embryonic antigen (CEA), Cyfra21-1, and neuron-specific enolase (NSE) in the serum samples of patients. With ≈50-fold enhancement of NIR fluorescence, multiplexed microarray analysis of CEA, Cyfra21-1, and NSE in 10 μL of human serum or whole blood samples on pGOLD chip leads to markedly improved limit-of-quantification, limit-of-detection, reproducibility, and higher diagnostic sensitivity and specificity compared to traditional biochips and Luminex technology currently in use in hospitals.-
dc.languageeng-
dc.relation.ispartofAdvanced Functional Materials-
dc.subjectdiagnostics-
dc.subjectlung cancer-
dc.subjectmicroarrays-
dc.subjectplasmonic gold chips-
dc.subjectserum biomarkers-
dc.titleHigh Performance, Multiplexed Lung Cancer Biomarker Detection on a Plasmonic Gold Chip-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/adfm.201603547-
dc.identifier.scopuseid_2-s2.0-84988850608-
dc.identifier.volume26-
dc.identifier.issue44-
dc.identifier.spage7994-
dc.identifier.epage8002-
dc.identifier.eissn1616-3028-

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