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Article: Rates and correlates of medication non-adherence behaviors and attitudes in adult patients with early psychosis
Title | Rates and correlates of medication non-adherence behaviors and attitudes in adult patients with early psychosis |
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Authors | |
Keywords | Antipsychotics Attitudes towards medication Early psychosis Medication adherence Self-stigma |
Issue Date | 14-Oct-2023 |
Publisher | Springer |
Citation | Social Psychiatry and Psychiatric Epidemiology, 2023 How to Cite? |
Abstract | PurposeLiterature on antipsychotic medication adherence in early psychosis primarily assessed adherence behaviors and focused on young patients. There is a paucity of research investigating negative medication attitude and its determinants in the early illness course, particularly in older-aged sample. We aimed to examine prevalence and correlates of medication non-adherence behaviors and negative medication attitudes separately in adult patients with early psychosis. MethodsOne hundred ninety-nine Chinese early psychosis patients aged 26–55 years who had received three-year treatment for first psychotic episode in Hong Kong were examined. Assessments encompassing socio-demographics, premorbid adjustment, clinical and treatment profiles, self-stigma and therapeutic alliance were conducted. Patients were evaluated with Medication Compliance Questionnaire, which is a modified Chinese-translated version of Medication Adherence Rating Scale and includes items measuring adherence behaviors and attitudes towards medications. ResultsRates of medication non-adherence and negative attitude towards medications were 38.7% and 50.8%, respectively. Multivariate regression analysis showed that more severe positive symptoms, greater self-stigma and negative medication attitude were independently associated with medication non-adherence. Negative attitude towards medications was significantly associated with younger age, higher educational attainment, diagnosis of other psychotic disorders, poorer insight, greater self-stigma and less satisfaction with communication with healthcare staff, which represented an index reflecting suboptimal therapeutic alliance. ConclusionAntipsychotic non-adherence and negative medication attitudes are frequently observed in adult early psychosis patients. Our findings indicate that poor insight, elevated self-stigma and suboptimal therapeutic alliance may constitute potential treatment targets for promoting medication adherence and rectifying negative medication attitudes in the early illness stage. |
Persistent Identifier | http://hdl.handle.net/10722/339904 |
ISSN | 2021 Impact Factor: 4.519 2020 SCImago Journal Rankings: 1.863 |
DC Field | Value | Language |
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dc.contributor.author | So, Yuen Kiu | - |
dc.contributor.author | Chan, Ching Yui | - |
dc.contributor.author | Fung, Shi Cheng | - |
dc.contributor.author | Lui, Tsz Ting | - |
dc.contributor.author | Lau, Fu Chun | - |
dc.contributor.author | Chan, Kit Wa | - |
dc.contributor.author | Lee, Ho Ming | - |
dc.contributor.author | Lui Sai Yu | - |
dc.contributor.author | Hui, Lai Ming | - |
dc.contributor.author | Chen, Eric | - |
dc.contributor.author | Chang, Wing Chung | - |
dc.date.accessioned | 2024-03-11T10:40:12Z | - |
dc.date.available | 2024-03-11T10:40:12Z | - |
dc.date.issued | 2023-10-14 | - |
dc.identifier.citation | Social Psychiatry and Psychiatric Epidemiology, 2023 | - |
dc.identifier.issn | 0933-7954 | - |
dc.identifier.uri | http://hdl.handle.net/10722/339904 | - |
dc.description.abstract | <h3>Purpose</h3><p>Literature on antipsychotic medication adherence in early psychosis primarily assessed adherence behaviors and focused on young patients. There is a paucity of research investigating negative medication attitude and its determinants in the early illness course, particularly in older-aged sample. We aimed to examine prevalence and correlates of medication non-adherence behaviors and negative medication attitudes separately in adult patients with early psychosis.</p><h3>Methods</h3><p>One hundred ninety-nine Chinese early psychosis patients aged 26–55 years who had received three-year treatment for first psychotic episode in Hong Kong were examined. Assessments encompassing socio-demographics, premorbid adjustment, clinical and treatment profiles, self-stigma and therapeutic alliance were conducted. Patients were evaluated with Medication Compliance Questionnaire, which is a modified Chinese-translated version of Medication Adherence Rating Scale and includes items measuring adherence behaviors and attitudes towards medications.</p><h3>Results</h3><p>Rates of medication non-adherence and negative attitude towards medications were 38.7% and 50.8%, respectively. Multivariate regression analysis showed that more severe positive symptoms, greater self-stigma and negative medication attitude were independently associated with medication non-adherence. Negative attitude towards medications was significantly associated with younger age, higher educational attainment, diagnosis of other psychotic disorders, poorer insight, greater self-stigma and less satisfaction with communication with healthcare staff, which represented an index reflecting suboptimal therapeutic alliance.</p><h3>Conclusion</h3><p>Antipsychotic non-adherence and negative medication attitudes are frequently observed in adult early psychosis patients. Our findings indicate that poor insight, elevated self-stigma and suboptimal therapeutic alliance may constitute potential treatment targets for promoting medication adherence and rectifying negative medication attitudes in the early illness stage.</p> | - |
dc.language | eng | - |
dc.publisher | Springer | - |
dc.relation.ispartof | Social Psychiatry and Psychiatric Epidemiology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Antipsychotics | - |
dc.subject | Attitudes towards medication | - |
dc.subject | Early psychosis | - |
dc.subject | Medication adherence | - |
dc.subject | Self-stigma | - |
dc.title | Rates and correlates of medication non-adherence behaviors and attitudes in adult patients with early psychosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s00127-023-02563-4 | - |
dc.identifier.scopus | eid_2-s2.0-85174180860 | - |
dc.identifier.eissn | 1433-9285 | - |
dc.identifier.issnl | 0933-7954 | - |