File Download

There are no files associated with this item.

Supplementary

Conference Paper: Astrocyte Dysfunction Drives Abnormal Resting-State Functional Connectivity In Depression

TitleAstrocyte Dysfunction Drives Abnormal Resting-State Functional Connectivity In Depression
Authors
Liu, JMo, JWWang, XAn, ZZhang, SZhang, CYYi, PLeong, ATLRen, JChen, LYMo, RXie, YFeng, QChen, WGao, TMWu, EXFeng, YCao, X
Issue Date6-Jun-2023
Abstract

Even though brain-wide network-level abnormalities in major depressive disorder (MDD) patients via resting-state functional MRI (rsfMRI) exist, the mechanisms underlying such network changes are unknown. Here, we show that the astrocytic calcium deficient mice, inositol 1,4,5-trisphosphate-type-2 receptor knockout mice (Itpr2-/- mice), display abnormal rsfMRI connectivity (rsFC), which is highly consistent with those of MDD patients. Optogenetic activation of medial prefrontal cortex (mPFC) astrocytes partially rescues rsFC. Optogenetic activation of the mPFC neurons or mPFC-striatum pathway rescues disrupted rsFC and depressive-like behaviors in Itpr2-/- mice. Our results identify the previously unknown role of astrocyte dysfunction in driving rsFC


Persistent Identifierhttp://hdl.handle.net/10722/340453

 

DC FieldValueLanguage
dc.contributor.authorLiu, J-
dc.contributor.authorMo, JW-
dc.contributor.authorWang, X-
dc.contributor.authorAn, Z-
dc.contributor.authorZhang, S-
dc.contributor.authorZhang, CY-
dc.contributor.authorYi, P-
dc.contributor.authorLeong, ATL-
dc.contributor.authorRen, J-
dc.contributor.authorChen, LY-
dc.contributor.authorMo, R-
dc.contributor.authorXie, Y-
dc.contributor.authorFeng, Q-
dc.contributor.authorChen, W-
dc.contributor.authorGao, TM-
dc.contributor.authorWu, EX-
dc.contributor.authorFeng, Y-
dc.contributor.authorCao, X-
dc.date.accessioned2024-03-11T10:44:45Z-
dc.date.available2024-03-11T10:44:45Z-
dc.date.issued2023-06-06-
dc.identifier.urihttp://hdl.handle.net/10722/340453-
dc.description.abstract<p>Even though brain-wide network-level abnormalities in major depressive disorder (MDD) patients via resting-state functional MRI (rsfMRI) exist, the mechanisms underlying such network changes are unknown. Here, we show that the astrocytic calcium deficient mice, inositol 1,4,5-trisphosphate-type-2 receptor knockout mice (<em>Itpr2<sup>-/-</sup></em> mice), display abnormal rsfMRI connectivity (rsFC), which is highly consistent with those of MDD patients. Optogenetic activation of medial prefrontal cortex (mPFC) astrocytes partially rescues rsFC. Optogenetic activation of the mPFC neurons or mPFC-striatum pathway rescues disrupted rsFC and depressive-like behaviors in<em> Itpr2<sup>-/-</sup></em> mice. Our results identify the previously unknown role of astrocyte dysfunction in driving rsFC<br></p>-
dc.languageeng-
dc.relation.ispartof2023 ISMRM & ISMRT Annual Meeting & Exhibition (03/06/2023-08/06/2023, Toronto)-
dc.titleAstrocyte Dysfunction Drives Abnormal Resting-State Functional Connectivity In Depression-
dc.typeConference_Paper-

Export via OAI-PMH Interface in XML Formats

OR

Export to Other Non-XML Formats