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Article: Sphingomyelin synthases and testicular function
Title | Sphingomyelin synthases and testicular function |
---|---|
Authors | |
Keywords | Acrosome formation Lipid metabolism Spermatogenesis Sphingomyelin synthase Testis |
Issue Date | 2008 |
Publisher | Expert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/eem |
Citation | Expert Review Of Endocrinology And Metabolism, 2008, v. 3 n. 5, p. 593-601 How to Cite? |
Abstract | Sphingomyelin synthase (SMS) is a cellular enzyme that catalyzes de novo synthesis of sphingomyelin (SM), which is a vital lipid component of cell membranes. Both members of the SMS family, SMS1 and SMS2, are found in mammalian testes and they are located in distinctive subcellular compartments, with SMS1 in the Golgi apparatus and SMS2 in the plasma membrane. At present, the precise function of SMS in the testis remains unknown. Recent studies have demonstrated an unique association of SMS2 with spermatids, particularly near developing acrosomes and the junction restructuring site at the apical ectoplasmic specialization (a testis-specific atypical adherens junction type) and Leydig cells in the rat testis. These data illustrate the possible involvement of SMS2 in spermiogenesis and, perhaps, steroidogenesis in male reproductive function. This review summarizes the latest findings on SMS in the field, particularly its role in testicular function. © 2008 Expert Reviews Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/59987 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.904 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, NPY | en_HK |
dc.contributor.author | Wong, EWP | en_HK |
dc.contributor.author | Mruk, DD | en_HK |
dc.contributor.author | Cheng, CY | en_HK |
dc.date.accessioned | 2010-05-31T04:01:27Z | - |
dc.date.available | 2010-05-31T04:01:27Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | Expert Review Of Endocrinology And Metabolism, 2008, v. 3 n. 5, p. 593-601 | en_HK |
dc.identifier.issn | 1744-6651 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/59987 | - |
dc.description.abstract | Sphingomyelin synthase (SMS) is a cellular enzyme that catalyzes de novo synthesis of sphingomyelin (SM), which is a vital lipid component of cell membranes. Both members of the SMS family, SMS1 and SMS2, are found in mammalian testes and they are located in distinctive subcellular compartments, with SMS1 in the Golgi apparatus and SMS2 in the plasma membrane. At present, the precise function of SMS in the testis remains unknown. Recent studies have demonstrated an unique association of SMS2 with spermatids, particularly near developing acrosomes and the junction restructuring site at the apical ectoplasmic specialization (a testis-specific atypical adherens junction type) and Leydig cells in the rat testis. These data illustrate the possible involvement of SMS2 in spermiogenesis and, perhaps, steroidogenesis in male reproductive function. This review summarizes the latest findings on SMS in the field, particularly its role in testicular function. © 2008 Expert Reviews Ltd. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Expert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/eem | en_HK |
dc.relation.ispartof | Expert Review of Endocrinology and Metabolism | en_HK |
dc.subject | Acrosome formation | en_HK |
dc.subject | Lipid metabolism | en_HK |
dc.subject | Spermatogenesis | en_HK |
dc.subject | Sphingomyelin synthase | en_HK |
dc.subject | Testis | en_HK |
dc.title | Sphingomyelin synthases and testicular function | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lee, NPY: nikkilee@hku.hk | en_HK |
dc.identifier.authority | Lee, NPY=rp00263 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1586/17446651.3.5.593 | en_HK |
dc.identifier.scopus | eid_2-s2.0-55649110660 | en_HK |
dc.identifier.hkuros | 165221 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-55649110660&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 3 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 593 | en_HK |
dc.identifier.epage | 601 | en_HK |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Lee, NPY=7402722690 | en_HK |
dc.identifier.scopusauthorid | Wong, EWP=23029194700 | en_HK |
dc.identifier.scopusauthorid | Mruk, DD=6701823934 | en_HK |
dc.identifier.scopusauthorid | Cheng, CY=7404797787 | en_HK |
dc.identifier.citeulike | 3199512 | - |
dc.identifier.issnl | 1744-6651 | - |