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- Publisher Website: 10.1007/978-1-59745-242-7-2
- Scopus: eid_2-s2.0-84934437864
- PMID: 18369908
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Article: A voluntary oral-feeding rat model for pathological alcoholic liver injury
Title | A voluntary oral-feeding rat model for pathological alcoholic liver injury |
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Authors | |
Keywords | Alcoholic liver injury Cytokines Nitric oxide Rodents |
Issue Date | 2008 |
Publisher | Humana Press, Inc. |
Citation | Methods In Molecular Biology, 2008, v. 447, p. 11-31 How to Cite? |
Abstract | The variety of animal models used in the study of alcoholic liver disease reflects the formidable task of developing a model that replicates the human disease. We show that oral feeding of fatty acids derived from fish oil and ethanol induces fatty liver, necrosis, inflammation, and fibrosis. Together with the study of oxidative and nitrosative stress markers, cytokines, proteasome function, and protein studies, this model has provided an inexpensive and technically simple method of establishing pathological alcoholic liver injury. © 2008 Humana Press, a part of Springer Science + Business Media, LLC. |
Persistent Identifier | http://hdl.handle.net/10722/67475 |
ISSN | 2023 SCImago Journal Rankings: 0.399 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tipoe, GL | en_HK |
dc.contributor.author | Liong, EC | en_HK |
dc.contributor.author | Leung, TM | en_HK |
dc.contributor.author | Nanji, AA | en_HK |
dc.date.accessioned | 2010-09-06T05:55:28Z | - |
dc.date.available | 2010-09-06T05:55:28Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | Methods In Molecular Biology, 2008, v. 447, p. 11-31 | en_HK |
dc.identifier.issn | 1064-3745 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67475 | - |
dc.description.abstract | The variety of animal models used in the study of alcoholic liver disease reflects the formidable task of developing a model that replicates the human disease. We show that oral feeding of fatty acids derived from fish oil and ethanol induces fatty liver, necrosis, inflammation, and fibrosis. Together with the study of oxidative and nitrosative stress markers, cytokines, proteasome function, and protein studies, this model has provided an inexpensive and technically simple method of establishing pathological alcoholic liver injury. © 2008 Humana Press, a part of Springer Science + Business Media, LLC. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Humana Press, Inc. | en_HK |
dc.relation.ispartof | Methods in Molecular Biology | en_HK |
dc.subject | Alcoholic liver injury | - |
dc.subject | Cytokines | - |
dc.subject | Nitric oxide | - |
dc.subject | Rodents | - |
dc.subject.mesh | Administration, Oral | en_HK |
dc.subject.mesh | Alanine Transaminase - blood | en_HK |
dc.subject.mesh | Alcohol Drinking - genetics - metabolism - pathology | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Blotting, Western | en_HK |
dc.subject.mesh | Central Nervous System Depressants - administration & dosage - metabolism | en_HK |
dc.subject.mesh | Chymotrypsin - metabolism | en_HK |
dc.subject.mesh | Cytochrome P-450 CYP2E1 - metabolism | en_HK |
dc.subject.mesh | Dinoprost - analogs & derivatives - blood | en_HK |
dc.subject.mesh | Disease Models, Animal | en_HK |
dc.subject.mesh | Electrophoretic Mobility Shift Assay | en_HK |
dc.subject.mesh | Endotoxins - blood | en_HK |
dc.subject.mesh | Ethanol - administration & dosage - metabolism | en_HK |
dc.subject.mesh | Fatty Acids - administration & dosage | en_HK |
dc.subject.mesh | Fatty Liver, Alcoholic - pathology | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Immunohistochemistry | en_HK |
dc.subject.mesh | Liver - enzymology - pathology | en_HK |
dc.subject.mesh | Liver Diseases, Alcoholic - genetics - metabolism - pathology | en_HK |
dc.subject.mesh | Oxidative Stress | en_HK |
dc.subject.mesh | Rats | en_HK |
dc.subject.mesh | Rats, Wistar | en_HK |
dc.subject.mesh | Reverse Transcriptase Polymerase Chain Reaction | en_HK |
dc.subject.mesh | Self Administration | en_HK |
dc.subject.mesh | Specimen Handling | en_HK |
dc.subject.mesh | Staining and Labeling | en_HK |
dc.subject.mesh | Thiobarbituric Acid Reactive Substances - metabolism | en_HK |
dc.title | A voluntary oral-feeding rat model for pathological alcoholic liver injury | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1064-3745&volume=447&spage=11&epage=31&date=2008&atitle=A+voluntary+oral-feeding+rat+model+for+pathological+alcoholic+liver+injury | en_HK |
dc.identifier.email | Tipoe, GL:tgeorge@hkucc.hku.hk | en_HK |
dc.identifier.authority | Tipoe, GL=rp00371 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/978-1-59745-242-7-2 | en_HK |
dc.identifier.pmid | 18369908 | en_HK |
dc.identifier.scopus | eid_2-s2.0-84934437864 | en_HK |
dc.identifier.hkuros | 141690 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-43549083079&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 447 | en_HK |
dc.identifier.spage | 11 | en_HK |
dc.identifier.epage | 31 | en_HK |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Tipoe, GL=7003550610 | en_HK |
dc.identifier.scopusauthorid | Liong, EC=6602732210 | en_HK |
dc.identifier.scopusauthorid | Leung, TM=7202110149 | en_HK |
dc.identifier.scopusauthorid | Nanji, AA=35885060300 | en_HK |
dc.identifier.issnl | 1064-3745 | - |