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Article: E-cadherin upregulation as a therapeutic goal in cancer treatment

TitleE-cadherin upregulation as a therapeutic goal in cancer treatment
Authors
Howard, EWCamm, KDWong, YCWang, XH
KeywordsCancer
Cell adhesion
Chemotherapy
E-cadherin
Epigenetics
Epithelial-mesenchymal transition
Metastasis
Transcriptional repressors
Issue Date2008
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/mrmc/index.htm
Citation
Mini-Reviews In Medicinal Chemistry, 2008, v. 8 n. 5, p. 496-518 How to Cite?
DOI: http://dx.doi.org/10.2174/138955708784223521
AbstractWe review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis. © 2008 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/67536
ISSN
1389-5575
2021 Impact Factor: 3.737
2020 SCImago Journal Rankings: 0.603
ISI Accession Number ID
WOS:000256196200008
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorHoward, EWen_HK
dc.contributor.authorCamm, KDen_HK
dc.contributor.authorWong, YCen_HK
dc.contributor.authorWang, XHen_HK
dc.date.accessioned2010-09-06T05:56:00Z-
dc.date.available2010-09-06T05:56:00Z-
dc.date.issued2008en_HK
dc.identifier.citationMini-Reviews In Medicinal Chemistry, 2008, v. 8 n. 5, p. 496-518en_HK
dc.identifier.issn1389-5575en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67536-
dc.description.abstractWe review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis. © 2008 Bentham Science Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/mrmc/index.htmen_HK
dc.relation.ispartofMini-Reviews in Medicinal Chemistryen_HK
dc.subjectCancer-
dc.subjectCell adhesion-
dc.subjectChemotherapy-
dc.subjectE-cadherin-
dc.subjectEpigenetics-
dc.subjectEpithelial-mesenchymal transition-
dc.subjectMetastasis-
dc.subjectTranscriptional repressors-
dc.subject.meshAntineoplastic Agents - chemistry - pharmacology - therapeutic useen_HK
dc.subject.meshCadherins - drug effects - genetics - metabolismen_HK
dc.subject.meshGene Expression Regulation - drug effectsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshNeoplasms - drug therapy - metabolismen_HK
dc.subject.meshTranscription, Genetic - drug effects - geneticsen_HK
dc.subject.meshUp-Regulation - drug effectsen_HK
dc.titleE-cadherin upregulation as a therapeutic goal in cancer treatmenten_HK
dc.typeArticleen_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/138955708784223521en_HK
dc.identifier.pmid18473938-
dc.identifier.scopuseid_2-s2.0-45549101665en_HK
dc.identifier.hkuros147318en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-45549101665&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue5en_HK
dc.identifier.spage496en_HK
dc.identifier.epage518en_HK
dc.identifier.isiWOS:000256196200008-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridHoward, EW=16480736900en_HK
dc.identifier.scopusauthoridCamm, KD=6507878232en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridWang, XH=7501854829en_HK
dc.identifier.citeulike2751146-
dc.identifier.issnl1389-5575-

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