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- Publisher Website: 10.1097/00004347-200301000-00013
- Scopus: eid_2-s2.0-0037214056
- PMID: 12496700
- WOS: WOS:000180024800013
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Article: Expression of E-cadherin and beta-catenin in trophoblastic tissue in normal and pathological pregnancies
Title | Expression of E-cadherin and beta-catenin in trophoblastic tissue in normal and pathological pregnancies |
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Authors | |
Keywords | β-catenin E-cadherin Normal and pathological pregnancies Trophoblastic tissue |
Issue Date | 2003 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.com |
Citation | International Journal Of Gynecological Pathology, 2003, v. 22 n. 1, p. 63-70 How to Cite? |
Abstract | E-cadherin and β-catenin are cell-cell adhesion molecules, which are thought to play an important role in trophoblastic differentiation and remodelling during gestation. Their expression may be altered in pathological conditions with trophoblastic invasion. In this study, we used immunohistochemical methods to study the pattern of expression of E-cadherin and β-catenin in villous trophoblastic tissue in normal and pathological pregnancies. In villous trophoblastic tissue, E-cadherin had a membranous distribution, whereas β-catenin had a mixed-membranous and granular cytoplasmic distribution. The levels of expression of E-cadherin and β-catenin correlated with each other. From first to third trimesters, the expression of both E-cadherin and β-catenin showed a decreasing trend. In preeclampsia, there was an up-regulation of E-cadherin and β-catenin expression. In placenta accreta, the level of expression of both did not differ from that in normal third-trimester placenta. In gestational trophoblastic diseases, there was a general trend of down-regulation of both E-cadherin and β-catenin. Altered expression of E-cadherin and β-catenin may play a role in the development of normal and pathological placentas. |
Persistent Identifier | http://hdl.handle.net/10722/67562 |
ISSN | 2023 Impact Factor: 1.6 2023 SCImago Journal Rankings: 0.640 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, HW | en_HK |
dc.contributor.author | Cheung, ANY | en_HK |
dc.contributor.author | Tsao, SW | en_HK |
dc.contributor.author | Cheung, ALM | en_HK |
dc.contributor.author | O, WS | en_HK |
dc.date.accessioned | 2010-09-06T05:56:14Z | - |
dc.date.available | 2010-09-06T05:56:14Z | - |
dc.date.issued | 2003 | en_HK |
dc.identifier.citation | International Journal Of Gynecological Pathology, 2003, v. 22 n. 1, p. 63-70 | en_HK |
dc.identifier.issn | 0277-1691 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67562 | - |
dc.description.abstract | E-cadherin and β-catenin are cell-cell adhesion molecules, which are thought to play an important role in trophoblastic differentiation and remodelling during gestation. Their expression may be altered in pathological conditions with trophoblastic invasion. In this study, we used immunohistochemical methods to study the pattern of expression of E-cadherin and β-catenin in villous trophoblastic tissue in normal and pathological pregnancies. In villous trophoblastic tissue, E-cadherin had a membranous distribution, whereas β-catenin had a mixed-membranous and granular cytoplasmic distribution. The levels of expression of E-cadherin and β-catenin correlated with each other. From first to third trimesters, the expression of both E-cadherin and β-catenin showed a decreasing trend. In preeclampsia, there was an up-regulation of E-cadherin and β-catenin expression. In placenta accreta, the level of expression of both did not differ from that in normal third-trimester placenta. In gestational trophoblastic diseases, there was a general trend of down-regulation of both E-cadherin and β-catenin. Altered expression of E-cadherin and β-catenin may play a role in the development of normal and pathological placentas. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.com | en_HK |
dc.relation.ispartof | International Journal of Gynecological Pathology | en_HK |
dc.rights | International Journal of Gynecological Pathology. Copyright © Lippincott Williams & Wilkins. | en_HK |
dc.subject | β-catenin | en_HK |
dc.subject | E-cadherin | en_HK |
dc.subject | Normal and pathological pregnancies | en_HK |
dc.subject | Trophoblastic tissue | en_HK |
dc.subject.mesh | Cadherins - biosynthesis | en_HK |
dc.subject.mesh | Cytoskeletal Proteins - biosynthesis | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Immunohistochemistry | en_HK |
dc.subject.mesh | Placenta Accreta - metabolism - pathology | en_HK |
dc.subject.mesh | Pre-Eclampsia - metabolism - pathology | en_HK |
dc.subject.mesh | Pregnancy | en_HK |
dc.subject.mesh | Trans-Activators - biosynthesis | en_HK |
dc.subject.mesh | Trophoblastic Neoplasms - metabolism - pathology | en_HK |
dc.subject.mesh | Trophoblasts - metabolism - pathology | en_HK |
dc.subject.mesh | Uterine Neoplasms - metabolism - pathology | en_HK |
dc.subject.mesh | beta Catenin | en_HK |
dc.title | Expression of E-cadherin and beta-catenin in trophoblastic tissue in normal and pathological pregnancies | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0277-1691&volume=22&spage=63&epage=70&date=2003&atitle=Expression+of+E-cadherin+and+beta-catenin+in+trophoblastic+tissue+in+normal+and+pathological+pregnancies | en_HK |
dc.identifier.email | Cheung, ANY:anycheun@hkucc.hku.hk | en_HK |
dc.identifier.email | Tsao, SW:gswtsao@hkucc.hku.hk | en_HK |
dc.identifier.email | Cheung, ALM:lmcheung@hkucc.hku.hk | en_HK |
dc.identifier.email | O, WS:owaisum@hkucc.hku.hk | en_HK |
dc.identifier.authority | Cheung, ANY=rp00542 | en_HK |
dc.identifier.authority | Tsao, SW=rp00399 | en_HK |
dc.identifier.authority | Cheung, ALM=rp00332 | en_HK |
dc.identifier.authority | O, WS=rp00315 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1097/00004347-200301000-00013 | en_HK |
dc.identifier.pmid | 12496700 | en_HK |
dc.identifier.scopus | eid_2-s2.0-0037214056 | en_HK |
dc.identifier.hkuros | 75839 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0037214056&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 22 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 63 | en_HK |
dc.identifier.epage | 70 | en_HK |
dc.identifier.isi | WOS:000180024800013 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Li, HW=37085839000 | en_HK |
dc.identifier.scopusauthorid | Cheung, ANY=7401806538 | en_HK |
dc.identifier.scopusauthorid | Tsao, SW=7102813116 | en_HK |
dc.identifier.scopusauthorid | Cheung, ALM=7401806497 | en_HK |
dc.identifier.scopusauthorid | O, WS=6701729369 | en_HK |
dc.identifier.issnl | 0277-1691 | - |