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- Publisher Website: 10.1053/sper.2001.23202
- Scopus: eid_2-s2.0-0035058952
- PMID: 11339664
- WOS: WOS:000168272000002
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Article: Capillary electrophoresis for the determination of albumin binding capacity and free bilirubin in jaundiced neonates
Title | Capillary electrophoresis for the determination of albumin binding capacity and free bilirubin in jaundiced neonates |
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Authors | |
Issue Date | 2001 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/semperi |
Citation | Seminars In Perinatology, 2001, v. 25 n. 2, p. 50-54 How to Cite? |
Abstract | This study develops a capillary electrophoresis/frontal analysis (CE/FA) method to separate free bilirubin from its albumin bound complex, with only small-sized samples. Under our optimized conditions, CE/FA is proven to be a simple and accurate method in assaying the concentration of free bilirubin in the jaundiced serum. Upon saturation of albumin-binding, the amount of bilirubin added to the serum bears a linear relationship with the absorbance at OD44OnM (R = .9987, P < .00001). Application of this method to study jaundiced neonates has yielded precise data on the residual binding capacity, which may be of significant therapeutic implications. The CE/FA method we have developed appears to be promising and applicable for clinical use as it is highly reproducible and it only requires a small sample size for tests. Our method should be an invaluable adjunct to the neonatal management of hyperbilirubinaemia. Copyright © 2001 by W.B. Saunders Company. |
Persistent Identifier | http://hdl.handle.net/10722/69498 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 1.035 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeung, CY | en_HK |
dc.contributor.author | Fung, YS | en_HK |
dc.contributor.author | Sun, DX | en_HK |
dc.date.accessioned | 2010-09-06T06:14:13Z | - |
dc.date.available | 2010-09-06T06:14:13Z | - |
dc.date.issued | 2001 | en_HK |
dc.identifier.citation | Seminars In Perinatology, 2001, v. 25 n. 2, p. 50-54 | en_HK |
dc.identifier.issn | 0146-0005 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/69498 | - |
dc.description.abstract | This study develops a capillary electrophoresis/frontal analysis (CE/FA) method to separate free bilirubin from its albumin bound complex, with only small-sized samples. Under our optimized conditions, CE/FA is proven to be a simple and accurate method in assaying the concentration of free bilirubin in the jaundiced serum. Upon saturation of albumin-binding, the amount of bilirubin added to the serum bears a linear relationship with the absorbance at OD44OnM (R = .9987, P < .00001). Application of this method to study jaundiced neonates has yielded precise data on the residual binding capacity, which may be of significant therapeutic implications. The CE/FA method we have developed appears to be promising and applicable for clinical use as it is highly reproducible and it only requires a small sample size for tests. Our method should be an invaluable adjunct to the neonatal management of hyperbilirubinaemia. Copyright © 2001 by W.B. Saunders Company. | en_HK |
dc.language | eng | en_HK |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/semperi | en_HK |
dc.relation.ispartof | Seminars in Perinatology | en_HK |
dc.title | Capillary electrophoresis for the determination of albumin binding capacity and free bilirubin in jaundiced neonates | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0146-0005&volume=25&issue=20&spage=50&epage=54&date=2001&atitle=Capillary+electrophoresis+for+the+determination+of+albumin+binding+capacity+and+free+bilirubin+in+jaundiced+neonates | en_HK |
dc.identifier.email | Fung, YS:ysfung@hku.hk | en_HK |
dc.identifier.authority | Fung, YS=rp00697 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1053/sper.2001.23202 | - |
dc.identifier.pmid | 11339664 | - |
dc.identifier.scopus | eid_2-s2.0-0035058952 | en_HK |
dc.identifier.hkuros | 62498 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035058952&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 25 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 50 | en_HK |
dc.identifier.epage | 54 | en_HK |
dc.identifier.isi | WOS:000168272000002 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Yeung, CY=7201354144 | en_HK |
dc.identifier.scopusauthorid | Fung, YS=13309754700 | en_HK |
dc.identifier.scopusauthorid | Sun, DX=36788445000 | en_HK |
dc.identifier.issnl | 0146-0005 | - |