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- Publisher Website: 10.1021/ol0475616
- Scopus: eid_2-s2.0-14844346999
- PMID: 15704921
- WOS: WOS:000226950100037
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Article: Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives
Title | Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives |
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Authors | |
Issue Date | 2005 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html |
Citation | Organic Letters, 2005, v. 7 n. 4, p. 669-672 How to Cite? |
Abstract | (Chemical Equation Presented) The synthesis of three fluorophore-appended derivatives of dioscin and polyphyllin D is reported herein. Starting from trillin, dansyl derivatives A-C were prepared in overall yields of 7-12% over 7-10 steps. A study of their behavior in a variety of polar solvents suggests that dansyl derivatives A-C are capable of micellar self-assembly and can maintain cytotoxicities (IC 50 = 15-18 μM) against the HeLa carcinoma cell line evaluated by standard MTT assay. © 2005 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/70370 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.245 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Yang, Z | en_HK |
dc.contributor.author | Wong, ELM | en_HK |
dc.contributor.author | Shum, TYT | en_HK |
dc.contributor.author | Che, CM | en_HK |
dc.contributor.author | Hui, Y | en_HK |
dc.date.accessioned | 2010-09-06T06:22:13Z | - |
dc.date.available | 2010-09-06T06:22:13Z | - |
dc.date.issued | 2005 | en_HK |
dc.identifier.citation | Organic Letters, 2005, v. 7 n. 4, p. 669-672 | en_HK |
dc.identifier.issn | 1523-7060 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/70370 | - |
dc.description.abstract | (Chemical Equation Presented) The synthesis of three fluorophore-appended derivatives of dioscin and polyphyllin D is reported herein. Starting from trillin, dansyl derivatives A-C were prepared in overall yields of 7-12% over 7-10 steps. A study of their behavior in a variety of polar solvents suggests that dansyl derivatives A-C are capable of micellar self-assembly and can maintain cytotoxicities (IC 50 = 15-18 μM) against the HeLa carcinoma cell line evaluated by standard MTT assay. © 2005 American Chemical Society. | en_HK |
dc.language | eng | en_HK |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html | en_HK |
dc.relation.ispartof | Organic Letters | en_HK |
dc.title | Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1523-7060&volume=7&spage=669&epage=672&date=2005&atitle=Fluorophore-appended+steroidal+saponin+(Dioscin+and+Polyphyllin+D)+derivatives | en_HK |
dc.identifier.email | Wong, ELM:wongella@hku.hk | en_HK |
dc.identifier.email | Che, CM:cmche@hku.hk | en_HK |
dc.identifier.authority | Wong, ELM=rp00807 | en_HK |
dc.identifier.authority | Che, CM=rp00670 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/ol0475616 | en_HK |
dc.identifier.pmid | 15704921 | - |
dc.identifier.scopus | eid_2-s2.0-14844346999 | en_HK |
dc.identifier.hkuros | 105842 | en_HK |
dc.identifier.hkuros | 132318 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-14844346999&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 7 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 669 | en_HK |
dc.identifier.epage | 672 | en_HK |
dc.identifier.isi | WOS:000226950100037 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Yang, Z=13205034800 | en_HK |
dc.identifier.scopusauthorid | Wong, ELM=8944839700 | en_HK |
dc.identifier.scopusauthorid | Shum, TYT=8922482200 | en_HK |
dc.identifier.scopusauthorid | Che, CM=7102442791 | en_HK |
dc.identifier.scopusauthorid | Hui, Y=7103107588 | en_HK |
dc.identifier.issnl | 1523-7052 | - |