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Article: Mycophenolate mofetil in the treatment of steroid-resistant primary focal segmental glomerulosclerosis

TitleMycophenolate mofetil in the treatment of steroid-resistant primary focal segmental glomerulosclerosis
Authors
Tang, SHo, YWLeung, CYLai, KN
KeywordsFocal segmental glomerulosclerosis
Mycophenolate mofetil
Remission
Steroid-resistance
Issue Date2005
PublisherWichtig Editore srl. The Journal's web site is located at http://www.jnephrol.com/index.asp?a=current
Citation
Journal Of Nephrology, 2005, v. 18 n. 4, p. 429-432 How to Cite?
AbstractWe report our experience in using mycophenolate mofetil (MMF) for the treatment of steroid-resistant focal segmental glomerulosclerosis (FSGS) in two patients. Patient 1, who was treated on disease presentation, responded well with sustained complete remission. Patient 2, who had unsuccessful steroid treatment 4 yrs before and was re-treated with MMF, showed transient retardation in renal disease progression but eventually progressed to end-stage renal failure. Our observation illustrates that MMF could be useful in treating steroid-resistant FSGS if administered at an early phase of the disease, well before histologic damage becomes irreversible. Its efficacy requires validation in randomized, controlled trials. The current armamentaria for the treatment of this condition are also discussed.
Persistent Identifierhttp://hdl.handle.net/10722/76563
ISSN
1121-8428
2021 Impact Factor: 4.393
2020 SCImago Journal Rankings: 1.044
ISI Accession Number ID
WOS:000232848400013
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorTang, Sen_HK
dc.contributor.authorHo, YWen_HK
dc.contributor.authorLeung, CYen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-09-06T07:22:34Z-
dc.date.available2010-09-06T07:22:34Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Nephrology, 2005, v. 18 n. 4, p. 429-432en_HK
dc.identifier.issn1121-8428en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76563-
dc.description.abstractWe report our experience in using mycophenolate mofetil (MMF) for the treatment of steroid-resistant focal segmental glomerulosclerosis (FSGS) in two patients. Patient 1, who was treated on disease presentation, responded well with sustained complete remission. Patient 2, who had unsuccessful steroid treatment 4 yrs before and was re-treated with MMF, showed transient retardation in renal disease progression but eventually progressed to end-stage renal failure. Our observation illustrates that MMF could be useful in treating steroid-resistant FSGS if administered at an early phase of the disease, well before histologic damage becomes irreversible. Its efficacy requires validation in randomized, controlled trials. The current armamentaria for the treatment of this condition are also discussed.en_HK
dc.languageengen_HK
dc.publisherWichtig Editore srl. The Journal's web site is located at http://www.jnephrol.com/index.asp?a=currenten_HK
dc.relation.ispartofJournal of Nephrologyen_HK
dc.subjectFocal segmental glomerulosclerosisen_HK
dc.subjectMycophenolate mofetilen_HK
dc.subjectRemissionen_HK
dc.subjectSteroid-resistanceen_HK
dc.subject.meshAgeden_HK
dc.subject.meshBiopsyen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshGlomerulosclerosis, Focal Segmental - drug therapy - pathologyen_HK
dc.subject.meshGlucocorticoids - therapeutic useen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunosuppressive Agents - therapeutic useen_HK
dc.subject.meshKidney Tubules - ultrastructureen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicroscopy, Electronen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMycophenolic Acid - analogs & derivatives - therapeutic useen_HK
dc.subject.meshProdrugs - therapeutic useen_HK
dc.subject.meshRemission Inductionen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.titleMycophenolate mofetil in the treatment of steroid-resistant primary focal segmental glomerulosclerosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1121-8428&volume=18&issue=4&spage=429&epage=432&date=2005&atitle=Mycophenolate+mofetil+in+the+treatment+of+steroid-resistant+primary+focal+segmental+glomerulosclerosisen_HK
dc.identifier.emailTang, S: scwtang@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityTang, S=rp00480en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid16245248-
dc.identifier.scopuseid_2-s2.0-28244474545en_HK
dc.identifier.hkuros121473en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-28244474545&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue4en_HK
dc.identifier.spage429en_HK
dc.identifier.epage432en_HK
dc.identifier.isiWOS:000232848400013-
dc.publisher.placeItalyen_HK
dc.identifier.scopusauthoridTang, S=7403437082en_HK
dc.identifier.scopusauthoridHo, YW=7402555047en_HK
dc.identifier.scopusauthoridLeung, CY=7402612388en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.issnl1121-8428-

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