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Article: Deletion 6q as a recurrent chromosomal aberration in T-cell large granular lymphocyte leukemia

TitleDeletion 6q as a recurrent chromosomal aberration in T-cell large granular lymphocyte leukemia
Authors
Man, CAu, WYPang, AKwong, YL
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2002, v. 139 n. 1, p. 71-74 How to Cite?
DOI: http://dx.doi.org/10.1016/S0165-4608(02)00605-2
AbstractT-cell large granular lymphocyte (T-LGL) leukemia is an uncommon disease, with limited information on karyotypic aberrations. No consistent chromosomal changes have thus far been described. We report two cases of T-LGL leukemia who presented with severe anemia. The LGL were CD3 +, CD4 -, CD8 +, CD56 -, and CD161 -, with variable expression of CD94, CD158a, and CD158b, and had clonal T-cell receptor gene rearrangement. A deletion of the long arm of chromosome 6 was the sole aberration in both cases. This is the first report of a recurrent chromosomal aberration in T-LGL leukemia. © 2002 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/76723
ISSN
0165-4608
2012 Impact Factor: 1.929
ISI Accession Number ID
WOS:000180163700016
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorMan, Cen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorPang, Aen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:24:15Z-
dc.date.available2010-09-06T07:24:15Z-
dc.date.issued2002en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 2002, v. 139 n. 1, p. 71-74en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76723-
dc.description.abstractT-cell large granular lymphocyte (T-LGL) leukemia is an uncommon disease, with limited information on karyotypic aberrations. No consistent chromosomal changes have thus far been described. We report two cases of T-LGL leukemia who presented with severe anemia. The LGL were CD3 +, CD4 -, CD8 +, CD56 -, and CD161 -, with variable expression of CD94, CD158a, and CD158b, and had clonal T-cell receptor gene rearrangement. A deletion of the long arm of chromosome 6 was the sole aberration in both cases. This is the first report of a recurrent chromosomal aberration in T-LGL leukemia. © 2002 Elsevier Science Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer genetics and Cytogenetics. Copyright © Elsevier Inc.en_HK
dc.subject.meshAntigens, CD - geneticsen_HK
dc.subject.meshBurkitt Lymphoma - geneticsen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshChromosome Mappingen_HK
dc.subject.meshChromosomes, Human, Pair 6en_HK
dc.subject.meshHumansen_HK
dc.subject.meshKaryotypingen_HK
dc.titleDeletion 6q as a recurrent chromosomal aberration in T-cell large granular lymphocyte leukemiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-4608&volume=139&issue=1&spage=71&epage=4&date=2002&atitle=Deletion+6q+as+a+recurrent+chromosomal+aberration+in+T-cell+large+granular+lymphocyte+leukemiaen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0165-4608(02)00605-2en_HK
dc.identifier.pmid12547164-
dc.identifier.scopuseid_2-s2.0-0036873737en_HK
dc.identifier.hkuros108948en_HK
dc.identifier.hkuros77907-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036873737&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume139en_HK
dc.identifier.issue1en_HK
dc.identifier.spage71en_HK
dc.identifier.epage74en_HK
dc.identifier.isiWOS:000180163700016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMan, C=7005722377en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridPang, A=7007044165en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.issnl0165-4608-

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