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Article: Suppression of Survivin Expression Inhibits in Vivo Tumorigenicity and Angiogenesis in Gastric Cancer

TitleSuppression of Survivin Expression Inhibits in Vivo Tumorigenicity and Angiogenesis in Gastric Cancer
Authors
Tu, SPJiang, XHLin, MCMCui, JTYang, YLum, CTZou, BZhu, YBJiang, SHWong, WMChan, AOOYuen, MFLam, SKKung, HFWong, BCY
Issue Date2003
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2003, v. 63 n. 22, p. 7724-7732 How to Cite?
AbstractSurvivin plays an important role in cancer development. We aim to show here that suppression of survivin expression or function by antisense and dominant-negative (DN) mutant can inhibit gastric cancer carcinogenesis and angiogenesis in vivo. Plasmid constructs expressing survivin antisense and DN mutant replacing the cysteine residue at amino acid 84 with alanine (Cys84Ala) were prepared and introduced into BCG-823 and MKN-45 gastric cancer cells to establish stable transfectants. We showed that both antisense and DN mutant stable transfectants exhibited abnormal morphology, with decreased cell growth and increased rate of spontaneous apoptosis and mitotic catastrophe. Furthermore, in nude mice xenografts, these cells exhibited decreased de novo gastric tumor formation and reduced development of angiogenesis. Results from these studies strongly suggest that survivin is a promising target for gastric cancer treatment.
Persistent Identifierhttp://hdl.handle.net/10722/78699
ISSN
0008-5472
2021 Impact Factor: 13.312
2020 SCImago Journal Rankings: 4.103
ISI Accession Number ID
WOS:000186770700033
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorTu, SPen_HK
dc.contributor.authorJiang, XHen_HK
dc.contributor.authorLin, MCMen_HK
dc.contributor.authorCui, JTen_HK
dc.contributor.authorYang, Yen_HK
dc.contributor.authorLum, CTen_HK
dc.contributor.authorZou, Ben_HK
dc.contributor.authorZhu, YBen_HK
dc.contributor.authorJiang, SHen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-06T07:45:45Z-
dc.date.available2010-09-06T07:45:45Z-
dc.date.issued2003en_HK
dc.identifier.citationCancer Research, 2003, v. 63 n. 22, p. 7724-7732en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78699-
dc.description.abstractSurvivin plays an important role in cancer development. We aim to show here that suppression of survivin expression or function by antisense and dominant-negative (DN) mutant can inhibit gastric cancer carcinogenesis and angiogenesis in vivo. Plasmid constructs expressing survivin antisense and DN mutant replacing the cysteine residue at amino acid 84 with alanine (Cys84Ala) were prepared and introduced into BCG-823 and MKN-45 gastric cancer cells to establish stable transfectants. We showed that both antisense and DN mutant stable transfectants exhibited abnormal morphology, with decreased cell growth and increased rate of spontaneous apoptosis and mitotic catastrophe. Furthermore, in nude mice xenografts, these cells exhibited decreased de novo gastric tumor formation and reduced development of angiogenesis. Results from these studies strongly suggest that survivin is a promising target for gastric cancer treatment.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.subject.meshAdenocarcinoma - blood supply - genetics - pathology - therapyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshApoptosis - geneticsen_HK
dc.subject.meshCell Division - geneticsen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshDNA, Antisense - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInhibitor of Apoptosis Proteinsen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred BALB Cen_HK
dc.subject.meshMice, Nudeen_HK
dc.subject.meshMicrotubule-Associated Proteins - antagonists & inhibitors - biosynthesis - geneticsen_HK
dc.subject.meshNeoplasm Proteinsen_HK
dc.subject.meshNeovascularization, Pathologic - genetics - therapyen_HK
dc.subject.meshStomach Neoplasms - blood supply - genetics - pathology - therapyen_HK
dc.subject.meshTransfectionen_HK
dc.subject.meshXenograft Model Antitumor Assaysen_HK
dc.titleSuppression of Survivin Expression Inhibits in Vivo Tumorigenicity and Angiogenesis in Gastric Canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-5472&volume=63&issue=22&spage=7724&epage=7732&date=2003&atitle=Suppression+of+Survivin+Expression+Inhibits+in+vivo+Tumorigenicity+and+Angiogenesis+in+Gastric+Canceren_HK
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.emailLum, CT:ctlum@graduate.hku.hken_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.identifier.authorityLum, CT=rp00757en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid14633697-
dc.identifier.scopuseid_2-s2.0-10744232690en_HK
dc.identifier.hkuros85118en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10744232690&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume63en_HK
dc.identifier.issue22en_HK
dc.identifier.spage7724en_HK
dc.identifier.epage7732en_HK
dc.identifier.isiWOS:000186770700033-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTu, SP=7202726555en_HK
dc.identifier.scopusauthoridJiang, XH=36089034900en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK
dc.identifier.scopusauthoridCui, JT=7401811557en_HK
dc.identifier.scopusauthoridYang, Y=8675011000en_HK
dc.identifier.scopusauthoridLum, CT=7006889374en_HK
dc.identifier.scopusauthoridZou, B=35228257300en_HK
dc.identifier.scopusauthoridZhu, YB=13008192300en_HK
dc.identifier.scopusauthoridJiang, SH=7404453122en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.issnl0008-5472-

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