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Article: Bone marrow transplantation for fanconi anaemia using a fludarabine-based preparative regimen with CD34+ cell selection
Title | Bone marrow transplantation for fanconi anaemia using a fludarabine-based preparative regimen with CD34+ cell selection |
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Authors | |
Keywords | Aplastic anaemia Bone marrow transplantation Fanconi anaemia |
Issue Date | 2006 |
Publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp |
Citation | Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 39-44 How to Cite? |
Abstract | Fanconi anaemia (FA) is an important cause of inherited aplastic anemia in childhood because of its relatively high frequency of occurrence, the implication for different management, and the need for genetic counselling. The common manifestations are congenital physical abnormalities, marrow failure, and predisposition to development of cancers. Bone marrow transplantation has been used to treat marrow failure for FA patients but they are at increased risks of transplant related toxicities and graft versus host disease. We report two children with FA who were treated successfully with matched sibling bone marrow transplantation using a new fludarabine-based conditioning regimen without irradiation. The stem cell source was from marrow which was infused after positive selection of CD34+ cells. Both patients had haematological recovery and no major post-transplant complications occurred. One achieved full donor chimerism and stable mixed chimerism was present in another. This regimen appears to be effective and can prevent FA patients from major transplant related complications. |
Persistent Identifier | http://hdl.handle.net/10722/80179 |
ISSN | 2023 Impact Factor: 0.1 2023 SCImago Journal Rankings: 0.117 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ha, SY | en_HK |
dc.contributor.author | Chan, GCF | en_HK |
dc.contributor.author | Chiang, AKS | en_HK |
dc.contributor.author | Lee, ACW | en_HK |
dc.contributor.author | Lee, TL | en_HK |
dc.contributor.author | Lau, YL | en_HK |
dc.date.accessioned | 2010-09-06T08:03:18Z | - |
dc.date.available | 2010-09-06T08:03:18Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 39-44 | en_HK |
dc.identifier.issn | 1013-9923 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/80179 | - |
dc.description.abstract | Fanconi anaemia (FA) is an important cause of inherited aplastic anemia in childhood because of its relatively high frequency of occurrence, the implication for different management, and the need for genetic counselling. The common manifestations are congenital physical abnormalities, marrow failure, and predisposition to development of cancers. Bone marrow transplantation has been used to treat marrow failure for FA patients but they are at increased risks of transplant related toxicities and graft versus host disease. We report two children with FA who were treated successfully with matched sibling bone marrow transplantation using a new fludarabine-based conditioning regimen without irradiation. The stem cell source was from marrow which was infused after positive selection of CD34+ cells. Both patients had haematological recovery and no major post-transplant complications occurred. One achieved full donor chimerism and stable mixed chimerism was present in another. This regimen appears to be effective and can prevent FA patients from major transplant related complications. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp | en_HK |
dc.relation.ispartof | Hong Kong Journal of Paediatrics | en_HK |
dc.subject | Aplastic anaemia | en_HK |
dc.subject | Bone marrow transplantation | en_HK |
dc.subject | Fanconi anaemia | en_HK |
dc.title | Bone marrow transplantation for fanconi anaemia using a fludarabine-based preparative regimen with CD34+ cell selection | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=11&spage=39&epage=44&date=2006&atitle=Bone+Marrow+Transplantation+for+Fanconi+Anaemia+Using+a+Fludarabine-based+Preparative+Regimen+with+CD34++Cell+Selection | en_HK |
dc.identifier.email | Chan, GCF:gcfchan@hkucc.hku.hk | en_HK |
dc.identifier.email | Chiang, AKS:chiangak@hkucc.hku.hk | en_HK |
dc.identifier.email | Lau, YL:lauylung@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chan, GCF=rp00431 | en_HK |
dc.identifier.authority | Chiang, AKS=rp00403 | en_HK |
dc.identifier.authority | Lau, YL=rp00361 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.scopus | eid_2-s2.0-31344443583 | en_HK |
dc.identifier.hkuros | 114557 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-31344443583&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 11 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 39 | en_HK |
dc.identifier.epage | 44 | en_HK |
dc.publisher.place | Hong Kong | en_HK |
dc.identifier.scopusauthorid | Ha, SY=7202501115 | en_HK |
dc.identifier.scopusauthorid | Chan, GCF=16160154400 | en_HK |
dc.identifier.scopusauthorid | Chiang, AKS=7101623534 | en_HK |
dc.identifier.scopusauthorid | Lee, ACW=7405631431 | en_HK |
dc.identifier.scopusauthorid | Lee, TL=24483772800 | en_HK |
dc.identifier.scopusauthorid | Lau, YL=7201403380 | en_HK |
dc.identifier.issnl | 1013-9923 | - |