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- Publisher Website: 10.1046/j.1365-2168.2001.01731.x
- Scopus: eid_2-s2.0-0035067359
- PMID: 11298623
- WOS: WOS:000168126000011
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Article: Decreased tyrosine kinase C expression may reflect developmental abnormalities in Hirschsprung's disease and idiopathic slow-transit constipation
Title | Decreased tyrosine kinase C expression may reflect developmental abnormalities in Hirschsprung's disease and idiopathic slow-transit constipation |
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Authors | |
Issue Date | 2001 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uk |
Citation | British Journal Of Surgery, 2001, v. 88 n. 4, p. 545-552 How to Cite? |
Abstract | Background: Some Patients With Hirschsprung's Disease Have Refractory Constipation Following Excision Of Aganglionic Bowel, As Do Patients With Idiopathic Slow-Transit Constipation (Stc). Gut Motility Depends On Enteric Neuronal Development In Response To Expression Of Trophic Factors And Their Receptors. Recent Studies Indicate The Importance Of Neurotrophin 3 (Nt-3) And Its High-Affinity Receptor Tyrosine Kinase C (Trk C) In Enteric Neuronal Development. Methods: Blinded Quantitative Immunohistochemical Analysis Of Colon From Patients With Hirschsprung's Disease (Aganglionic, Hypoganglionic And Normoganglionic) (N = 5), Stc (N = 6) And Appropriate Age-Matched Control Tissues (N = 5) Was Performed For Nt-3 And Trk C. Sural Nerve Morphometry And Immunostaining Were Undertaken In Three Patients With Stc Who Had Abnormalities On Limb Autonomic And Sensory Testing. Results: A Significantly Higher Proportion Of Submucous Plexus Neurones Was Trk C Immunoreactive In Control Infant Than Adult Colon (Mean(S.E.M.) 73(9) Versus 16(3) Per Cent Of The Total; P < 0.001), In Accord With A Role In Development. The Proportion Of Submucous Plexus Trk C-Immunoreactive Neurones Was Reduced In Colon From Patients With Hirschsprung's Disease (28(7) Per Cent Of Total In Normoganglionic Hirschsprung's Disease; P < 0.007 Versus Infant Controls) And Stc (10(1) Per Cent Of Total; P = 0.053 Versus Adult Controls). No Abnormalities Of Stc Sural Nerves Were Detected By Morphometry Or Immunostaining. Conclusion: Decreased Trk C Expression May Reflect Developmental Abnormalities In Hirschsprung's Disease And Idiopathic Stc. Trk C Activation By Nt-3 Or Drugs May Provide Novel Treatments. |
Persistent Identifier | http://hdl.handle.net/10722/84070 |
ISSN | 2023 Impact Factor: 8.6 2023 SCImago Journal Rankings: 2.148 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Facer, P | en_HK |
dc.contributor.author | Knowles, CH | en_HK |
dc.contributor.author | Thomas, PK | en_HK |
dc.contributor.author | Tam, PKH | en_HK |
dc.contributor.author | Williams, NS | en_HK |
dc.contributor.author | Anand, P | en_HK |
dc.date.accessioned | 2010-09-06T08:48:34Z | - |
dc.date.available | 2010-09-06T08:48:34Z | - |
dc.date.issued | 2001 | en_HK |
dc.identifier.citation | British Journal Of Surgery, 2001, v. 88 n. 4, p. 545-552 | en_US |
dc.identifier.issn | 0007-1323 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/84070 | - |
dc.description.abstract | Background: Some Patients With Hirschsprung's Disease Have Refractory Constipation Following Excision Of Aganglionic Bowel, As Do Patients With Idiopathic Slow-Transit Constipation (Stc). Gut Motility Depends On Enteric Neuronal Development In Response To Expression Of Trophic Factors And Their Receptors. Recent Studies Indicate The Importance Of Neurotrophin 3 (Nt-3) And Its High-Affinity Receptor Tyrosine Kinase C (Trk C) In Enteric Neuronal Development. Methods: Blinded Quantitative Immunohistochemical Analysis Of Colon From Patients With Hirschsprung's Disease (Aganglionic, Hypoganglionic And Normoganglionic) (N = 5), Stc (N = 6) And Appropriate Age-Matched Control Tissues (N = 5) Was Performed For Nt-3 And Trk C. Sural Nerve Morphometry And Immunostaining Were Undertaken In Three Patients With Stc Who Had Abnormalities On Limb Autonomic And Sensory Testing. Results: A Significantly Higher Proportion Of Submucous Plexus Neurones Was Trk C Immunoreactive In Control Infant Than Adult Colon (Mean(S.E.M.) 73(9) Versus 16(3) Per Cent Of The Total; P < 0.001), In Accord With A Role In Development. The Proportion Of Submucous Plexus Trk C-Immunoreactive Neurones Was Reduced In Colon From Patients With Hirschsprung's Disease (28(7) Per Cent Of Total In Normoganglionic Hirschsprung's Disease; P < 0.007 Versus Infant Controls) And Stc (10(1) Per Cent Of Total; P = 0.053 Versus Adult Controls). No Abnormalities Of Stc Sural Nerves Were Detected By Morphometry Or Immunostaining. Conclusion: Decreased Trk C Expression May Reflect Developmental Abnormalities In Hirschsprung's Disease And Idiopathic Stc. Trk C Activation By Nt-3 Or Drugs May Provide Novel Treatments. | en_US |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uk | en_HK |
dc.relation.ispartof | British Journal of Surgery | en_HK |
dc.rights | British Journal of Surgery. Copyright © John Wiley & Sons Ltd. | en_HK |
dc.title | Decreased tyrosine kinase C expression may reflect developmental abnormalities in Hirschsprung's disease and idiopathic slow-transit constipation | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1323&volume=88&spage=545&epage=552&date=2001&atitle=Decreased+tyrosine+kinase+C+expression+may+reflect+developmental+abnormalities+in+Hirschsprung%27s+disease+and+idiopathic+slow-transit+constipation | en_HK |
dc.identifier.email | Tam, PKH: paultam@hkucc.hku.hk | en_HK |
dc.identifier.authority | Tam, PKH=rp00060 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1046/j.1365-2168.2001.01731.x | en_US |
dc.identifier.pmid | 11298623 | - |
dc.identifier.scopus | eid_2-s2.0-0035067359 | en_US |
dc.identifier.hkuros | 61217 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035067359&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 88 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 545 | en_US |
dc.identifier.epage | 552 | en_US |
dc.identifier.isi | WOS:000168126000011 | - |
dc.identifier.issnl | 0007-1323 | - |