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- Publisher Website: 10.1093/ajcn/86.4.938
- Scopus: eid_2-s2.0-35148845528
- PMID: 17921368
- WOS: WOS:000250134600008
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Article: Isoflavone intake in persons at high risk of cardiovascular events: Implications for vascular endothelial function and the carotid atherosclerotic burden
Title | Isoflavone intake in persons at high risk of cardiovascular events: Implications for vascular endothelial function and the carotid atherosclerotic burden |
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Authors | |
Keywords | Carotid intima-media thickness Flow-mediated dilation Isoflavone |
Issue Date | 2007 |
Publisher | American Society for Nutrition. The Journal's web site is located at http://www.ajcn.org/ |
Citation | American Journal Of Clinical Nutrition, 2007, v. 86 n. 4, p. 938-945 How to Cite? |
Abstract | Background: Epidemiologic studies have suggested that a high phytoestrogen intake is inversely associated with cardiovascular disease risk factors and the incidence of cardiovascular events. However, the relation between the intake of isoflavone, a major component of phytoestrogen, and vascular endothelial function and the atherosclerotic burden remains unclear. Objective:Weaimed to investigate the effects of various dietary soy isoflavone intakes on brachial artery flow-mediated dilation and mean maximum carotid intima-media thickness. Design: We studied 126 consecutive patients (χ̄ ± SD age: 66.5 ± 11.1 y; 69% male) at high risk of cardiovascular events (94% had documented coronary artery disease or stroke; 44% had diabetes). A validated food-frequency questionnaire was used to estimate their dietary intake after they achieved stable dietary patterns for 3 mo. Results: The median intakes of isoflavone and soy protein were 5.5 (range: 2.2-13.3) mg/d and 1.2 (range: 0.4-2.8) g/d, respectively. Persons in the 4th quartile of daily isoflavone intake had significantly (P < 0.05) greater flow-mediated dilation - but not mean maximum carotid intima-media thickness - than did those in the lower quartiles. After adjustment for potential confounders, a higher isoflavone intake in the 4th than in the 1st quartile (>13.3 mg/d), but not a higher intake of soy protein, predicted an absolute 2.71% increase in flow-mediated dilation (relative increase: 103%; P = 0.02) and a 0.17-mm decrease in mean maximum carotid intima-media thickness (relative decrease: 14.5%; P = 0.04). Conclusion: In persons at high risk of cardiovascular events, a greater isoflavone intake is associated with better vascular endothelial function and lower carotid atherosclerotic burden. © 2007 American Society for Nutrition. |
Persistent Identifier | http://hdl.handle.net/10722/92563 |
ISSN | 2023 Impact Factor: 6.5 2023 SCImago Journal Rankings: 1.883 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Chan, YH | en_HK |
dc.contributor.author | Lau, KK | en_HK |
dc.contributor.author | Yiu, KH | en_HK |
dc.contributor.author | Li, SW | en_HK |
dc.contributor.author | Chan, HT | en_HK |
dc.contributor.author | Tam, S | en_HK |
dc.contributor.author | Shu, XO | en_HK |
dc.contributor.author | Lau, CP | en_HK |
dc.contributor.author | Tse, HF | en_HK |
dc.date.accessioned | 2010-09-17T10:50:12Z | - |
dc.date.available | 2010-09-17T10:50:12Z | - |
dc.date.issued | 2007 | en_HK |
dc.identifier.citation | American Journal Of Clinical Nutrition, 2007, v. 86 n. 4, p. 938-945 | en_HK |
dc.identifier.issn | 0002-9165 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/92563 | - |
dc.description.abstract | Background: Epidemiologic studies have suggested that a high phytoestrogen intake is inversely associated with cardiovascular disease risk factors and the incidence of cardiovascular events. However, the relation between the intake of isoflavone, a major component of phytoestrogen, and vascular endothelial function and the atherosclerotic burden remains unclear. Objective:Weaimed to investigate the effects of various dietary soy isoflavone intakes on brachial artery flow-mediated dilation and mean maximum carotid intima-media thickness. Design: We studied 126 consecutive patients (χ̄ ± SD age: 66.5 ± 11.1 y; 69% male) at high risk of cardiovascular events (94% had documented coronary artery disease or stroke; 44% had diabetes). A validated food-frequency questionnaire was used to estimate their dietary intake after they achieved stable dietary patterns for 3 mo. Results: The median intakes of isoflavone and soy protein were 5.5 (range: 2.2-13.3) mg/d and 1.2 (range: 0.4-2.8) g/d, respectively. Persons in the 4th quartile of daily isoflavone intake had significantly (P < 0.05) greater flow-mediated dilation - but not mean maximum carotid intima-media thickness - than did those in the lower quartiles. After adjustment for potential confounders, a higher isoflavone intake in the 4th than in the 1st quartile (>13.3 mg/d), but not a higher intake of soy protein, predicted an absolute 2.71% increase in flow-mediated dilation (relative increase: 103%; P = 0.02) and a 0.17-mm decrease in mean maximum carotid intima-media thickness (relative decrease: 14.5%; P = 0.04). Conclusion: In persons at high risk of cardiovascular events, a greater isoflavone intake is associated with better vascular endothelial function and lower carotid atherosclerotic burden. © 2007 American Society for Nutrition. | en_HK |
dc.language | eng | en_HK |
dc.publisher | American Society for Nutrition. The Journal's web site is located at http://www.ajcn.org/ | en_HK |
dc.relation.ispartof | American Journal of Clinical Nutrition | en_HK |
dc.subject | Carotid intima-media thickness | en_HK |
dc.subject | Flow-mediated dilation | en_HK |
dc.subject | Isoflavone | en_HK |
dc.subject.mesh | Aged | en_HK |
dc.subject.mesh | Analysis of Variance | en_HK |
dc.subject.mesh | Blood Flow Velocity | en_HK |
dc.subject.mesh | Blood Pressure - drug effects - physiology | en_HK |
dc.subject.mesh | Cardiovascular Diseases - epidemiology - metabolism | en_HK |
dc.subject.mesh | Carotid Arteries - pathology - ultrasonography | en_HK |
dc.subject.mesh | Diet Surveys | en_HK |
dc.subject.mesh | Endothelium, Vascular - drug effects - physiology | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Incidence | en_HK |
dc.subject.mesh | Isoflavones - administration & dosage | en_HK |
dc.subject.mesh | Lipid Metabolism - drug effects - physiology | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Questionnaires | en_HK |
dc.subject.mesh | Risk Factors | en_HK |
dc.subject.mesh | Soybean Proteins - administration & dosage | en_HK |
dc.subject.mesh | Soybeans - chemistry | en_HK |
dc.subject.mesh | Tunica Intima - pathology - ultrasonography | en_HK |
dc.subject.mesh | Tunica Media - pathology - ultrasonography | en_HK |
dc.title | Isoflavone intake in persons at high risk of cardiovascular events: Implications for vascular endothelial function and the carotid atherosclerotic burden | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Chan, YH:chanwill@hku.hk | en_HK |
dc.identifier.email | Lau, KK:gkklau@hku.hk | en_HK |
dc.identifier.email | Yiu, KH:khkyiu@hku.hk | en_HK |
dc.identifier.email | Tse, HF:hftse@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chan, YH=rp01313 | en_HK |
dc.identifier.authority | Lau, KK=rp01499 | en_HK |
dc.identifier.authority | Yiu, KH=rp01490 | en_HK |
dc.identifier.authority | Tse, HF=rp00428 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1093/ajcn/86.4.938 | - |
dc.identifier.pmid | 17921368 | - |
dc.identifier.scopus | eid_2-s2.0-35148845528 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-35148845528&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 86 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 938 | en_HK |
dc.identifier.epage | 945 | en_HK |
dc.identifier.isi | WOS:000250134600008 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Chan, YH=22633700600 | en_HK |
dc.identifier.scopusauthorid | Lau, KK=22635159600 | en_HK |
dc.identifier.scopusauthorid | Yiu, KH=35172267800 | en_HK |
dc.identifier.scopusauthorid | Li, SW=13807028100 | en_HK |
dc.identifier.scopusauthorid | Chan, HT=22633582100 | en_HK |
dc.identifier.scopusauthorid | Tam, S=7202037323 | en_HK |
dc.identifier.scopusauthorid | Shu, XO=7102525083 | en_HK |
dc.identifier.scopusauthorid | Lau, CP=7401968501 | en_HK |
dc.identifier.scopusauthorid | Tse, HF=7006070805 | en_HK |
dc.identifier.issnl | 0002-9165 | - |