A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Grant Data
Project Title
A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Principal Investigator
Professor Xu, Aimin
(Project Coordinator (PC))
Co-Investigator(s)
Professor Huang Yu
(Co-principal investigator)
Professor Vanhoutte Paul Michel Georges Remi
(Co-principal investigator)
Dr Woo Wai Hong Connie
(Co-principal investigator)
Professor Wang Yu
(Co-principal investigator)
Emeritus Professor Lam Karen Siu Ling
(Co-principal investigator)
Professor Wu Ed Xuekui
(Co-principal investigator)
Dr Cheng King Yip
(Co-principal investigator)
Duration
36
Start Date
2015-06-20
Amount
8780850
Conference Title
A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Presentation Title
Keywords
Adipokines, Adipose tissue inflammation, Atherosclerosis, Immunometabolism, Macrophage polarization
Discipline
Cardiovascular Research,Diabetes/Metabolism
HKU Project Code
C7055-14G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project
Funding Year
2014
Status
Completed
Objectives
1) To interrogate whether elevated miR-34a and reduced miR-883b in adipose tissues are important contributors to obesity-associated adipose tissue inflammation, vascular dysfunction and atherosclerosis in rodents and humans; 2) To investigate the molecular mechanism by which miR-34a and miR-883b fine-tunes macrophage infiltration and polarization in adipose tissues; 3) To elucidate how the two small lipid-binding adipokines (A-FABP and lipocalin-2) mediate obesity-induced M2→M1 macrophage polarization and vascular dysfunction in rodents; 4) To validate whether A-FABP and lipocalin-2 are viable therapeutic targets for obesityinduced adipose inflammation, endothelial dysfunction and atherosclerosis in pigs.
All Publications
Title | Author(s) | Issue Date | |
---|---|---|---|
2017 | |||
2016 | |||
2018 | |||
Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance Journal:Nature Communications | 2015 | ||
Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment Journal:ESC Heart Failure | 2017 | ||
2018 | |||
2016 | |||
Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury Journal:Journal of Clinical Investigation Insight | 2018 | ||
Heterogeneity of white adipose tissue: molecular basis and clinical implications Journal:Experimental & Molecular Medicine | 2016 | ||
2015 |