Role of protein arginine methyltransferase 6 (PRMT6) in metabolic reprogramming in hepatocellular carcinoma
Grant Data
Project Title
Role of protein arginine methyltransferase 6 (PRMT6) in metabolic reprogramming in hepatocellular carcinoma
Co-Investigator(s)
Professor Wong Carmen Chak Lui
(Co-Investigator)
Duration
30
Start Date
2018-01-01
Amount
767822
Conference Title
Role of protein arginine methyltransferase 6 (PRMT6) in metabolic reprogramming in hepatocellular carcinoma
Keywords
liver cancer, metabolic reprogramming, methylation, PKM2, PRMT6
Discipline
Gastroenterology/HepatobiliaryCancer
Panel
Biology and Medicine (M)
HKU Project Code
17105917
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To characterize the role of PRMT6 in regulating Warburg effect and metabolic activity of PKM2 in HCC. 2 To delineate the underlying molecular mechanism by which PRMT6 down-regulation in HCC contributes to metabolic reprogramming, with particular reference to IRS4/PI3K/AKT/mTOR/PKM2 signaling. 3 To evaluate the clinico-pathological relevance and prognostic significance of PRMT6 in combination with PKM2 in human HCC.
All Publications
| Title | Author(s) | Issue Date | |
|---|---|---|---|
| 2021 | |||
| 2020 |